ID   A0A182U8A4_9DIPT        Unreviewed;      1228 AA.
AC   A0A182U8A4;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   RecName: Full=Dead box {ECO:0008006|Google:ProtNLM};
OS   Anopheles melas.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC015739-PA, ECO:0000313|Proteomes:UP000075902};
RN   [1] {ECO:0000313|Proteomes:UP000075902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AMEC015739-PA}
RP   IDENTIFICATION.
RC   STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC015739-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   AlphaFoldDB; A0A182U8A4; -.
DR   STRING; 34690.A0A182U8A4; -.
DR   EnsemblMetazoa; AMEC015739-RA; AMEC015739-PA; AMEC015739.
DR   VEuPathDB; VectorBase:AMEC015739; -.
DR   Proteomes; UP000075902; Unassembled WGS sequence.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR   CDD; cd17935; EEXXQc_AQR; 1.
DR   CDD; cd18808; SF1_C_Upf1; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR048966; Aquarius_b-barrel.
DR   InterPro; IPR048967; Aquarius_insert.
DR   InterPro; IPR032174; Aquarius_N.
DR   InterPro; IPR026300; CWF11_fam.
DR   InterPro; IPR045055; DNA2/NAM7-like.
DR   InterPro; IPR041679; DNA2/NAM7-like_C.
DR   InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR047187; SF1_C_Upf1.
DR   PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR   PANTHER; PTHR10887:SF5; RNA HELICASE AQUARIUS; 1.
DR   Pfam; PF13086; AAA_11; 1.
DR   Pfam; PF13087; AAA_12; 1.
DR   Pfam; PF16399; Aquarius_N_1st; 1.
DR   Pfam; PF21143; Aquarius_N_2nd; 1.
DR   Pfam; PF21144; Aquarius_N_3rd; 1.
DR   PIRSF; PIRSF038901; AQR_cwf11; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   4: Predicted;
FT   DOMAIN          1..116
FT                   /note="RNA helicase aquarius N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16399"
FT   DOMAIN          196..368
FT                   /note="RNA helicase aquarius beta-barrel"
FT                   /evidence="ECO:0000259|Pfam:PF21143"
FT   DOMAIN          417..504
FT                   /note="RNA helicase aquarius insertion"
FT                   /evidence="ECO:0000259|Pfam:PF21144"
FT   DOMAIN          516..823
FT                   /note="DNA2/NAM7 helicase helicase"
FT                   /evidence="ECO:0000259|Pfam:PF13086"
FT   DOMAIN          832..1023
FT                   /note="DNA2/NAM7 helicase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13087"
FT   REGION          1051..1074
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1134..1228
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1164..1182
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1203..1228
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1228 AA;  141548 MW;  B294A2F5F0794ED8 CRC64;
     LLDMLKFYAR FEINDETGDP LTDHDMTQLH YAKIKSLQKA AFAKFPNLRL FALSNVANVD
     TRESLEKHFG ALDCDSLREI ACYLNLVPEK LEPPFEWHRA DETFLRELLI SRHERRVSQL
     ESLNEMPLYP TEDIIWNENV VPTEFYSGEG CLALPKLNLQ FLTLHDYLLR NFNLFRLEST
     YEIRQDIEDA VSRMLPWKSE EGDVVFGGWA RMALPIQSFA VVEVSKPHIG EKKPSRVRAD
     VSVTLNVRKE VQEEWENLRK HDVCFLVTVR PTQPIGTKYD YREHFVPQVG LVHVRGCEIE
     GMLDANGRVI EEGIEQRPQL TGEQRTFRVW LDSNQYRLDM DATLHATPGD DDDGREDVYE
     GFNIIMRRKP KENNFKAVLE TIRHLMNTEC VVPPWLHDIL LGYGDPGAAH YSRMPDQARV
     LDFNDTFLDF EHVSNSFPGY EIVSAAERPP GLNLLPPFRL TFENVPKGDG ADSEEEGAEQ
     REELSKRILV EPYRIPCRGP YKYNEPKKNV IRFTPTQIEA IRAGMQPGLT LVVGPPGTGK
     TDVAVQIISN LYHNHPQQRT LIVTHSNQAL NQLFEKIMAL DIDERHLLRL GHGEESLETE
     KDYSRYGRVN YVLSKRIDLL GQVQRLQESL GVSGDVAYTC ETAGHFYLYH VVARWEKFLS
     EFERDDEGQT GGSDDPAREQ FEAQFPFARF FRDAPQPLFG GATYAENMDI ARSCFRYVSH
     MFAELEEFRA FELLRSGLDR SKYLLVKEAK IIAMTCTHAA LKRKELVTMG FKYDNILMEE
     AAQILEIETF IPLLLQNPMD GYNRLKRWIM IGDHHQLPPV IKNMAFQKYS NMEQSLFTRL
     VRLGVPTIDL DGQGRARSSI CELYKWRYSR LGDLEHVHRW PEYCRANAGF AHEYQLINVE
     DFNGVGESEP NPYFYQNLAE AEYVVAVFMY MRLLGYPAEK ISILTTYNGQ KHLIRDVIES
     RCANNPMFGK PHKVTTVDKY QGQQNDYILL SLVRTKTIGH IRDVRRLVVA MSRARLGLYI
     FGRVALFKNC VELRPAFRLL MHRPLELQLH PEEKYGGGER QLQDGGSGAG EEGLSTRTVK
     DMTQMAQFVY QMYMQQVNVI REEMEKMKSL FEKQRQEQQQ EKMEEQIKIA DAEAEEAEKQ
     RQVEAAAKKD FAPTPIRNEI ADLGEPMDVA EKPRRGKKRV AAEEAVVPPP ATQEGEKDGE
     EEKAEEKTEE EDPKADEPEV EEKEQAED
//