ID A0A182U8P2_9DIPT Unreviewed; 1194 AA.
AC A0A182U8P2;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Tubulin beta chain {ECO:0008006|Google:ProtNLM};
OS Anopheles melas.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC015947-PA, ECO:0000313|Proteomes:UP000075902};
RN [1] {ECO:0000313|Proteomes:UP000075902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEC015947-PA}
RP IDENTIFICATION.
RC STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC015947-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBUNIT: Dimer of alpha and beta chains. A typical microtubule is a
CC hollow water-filled tube with an outer diameter of 25 nm and an inner
CC diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to
CC form protofilaments running lengthwise along the microtubule wall with
CC the beta-tubulin subunit facing the microtubule plus end conferring a
CC structural polarity. Microtubules usually have 13 protofilaments but
CC different protofilament numbers can be found in some organisms and
CC specialized cells. {ECO:0000256|ARBA:ARBA00011747}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the tubulin family.
CC {ECO:0000256|ARBA:ARBA00009636}.
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DR AlphaFoldDB; A0A182U8P2; -.
DR STRING; 34690.A0A182U8P2; -.
DR EnsemblMetazoa; AMEC015947-RA; AMEC015947-PA; AMEC015947.
DR VEuPathDB; VectorBase:AMEC015947; -.
DR Proteomes; UP000075902; Unassembled WGS sequence.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR CDD; cd02187; beta_tubulin; 1.
DR Gene3D; 1.10.287.600; Helix hairpin bin; 1.
DR Gene3D; 3.30.1330.20; Tubulin/FtsZ, C-terminal domain; 1.
DR Gene3D; 3.40.50.1440; Tubulin/FtsZ, GTPase domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002453; Beta_tubulin.
DR InterPro; IPR008280; Tub_FtsZ_C.
DR InterPro; IPR000217; Tubulin.
DR InterPro; IPR037103; Tubulin/FtsZ-like_C.
DR InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
DR InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR InterPro; IPR023123; Tubulin_C.
DR InterPro; IPR017975; Tubulin_CS.
DR InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR PANTHER; PTHR11588; TUBULIN; 1.
DR PANTHER; PTHR11588:SF484; TUBULIN BETA-2 CHAIN-RELATED; 1.
DR Pfam; PF00091; Tubulin; 1.
DR Pfam; PF03953; Tubulin_C; 1.
DR PRINTS; PR01163; BETATUBULIN.
DR PRINTS; PR01161; TUBULIN.
DR SMART; SM00864; Tubulin; 1.
DR SMART; SM00865; Tubulin_C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF55307; Tubulin C-terminal domain-like; 1.
DR SUPFAM; SSF52490; Tubulin nucleotide-binding domain-like; 1.
DR PROSITE; PS00227; TUBULIN; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 796..993
FT /note="Tubulin/FtsZ GTPase"
FT /evidence="ECO:0000259|SMART:SM00864"
FT DOMAIN 995..1132
FT /note="Tubulin/FtsZ 2-layer sandwich"
FT /evidence="ECO:0000259|SMART:SM00865"
FT REGION 1169..1194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1177..1194
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1194 AA; 134708 MW; CE6CB316B1D84F14 CRC64;
MEDGLFNALC CKVKNGKTIY HSWRELFQEE KDEGTMLVLQ LFIDMTGFGY TVADIDLALL
MEDDPHPLEH KITTSPQDFF QNGTFVANFS KFWQHALVHQ WKELLSGNDW FNKCVMLVML
LCRSKTDECA MVGSFICADL VPHLCAARHN LLNVMERAAS WQGNQRKSSL KKKEYYIDQV
CQALSTEIGN GFKYAKLSGL LMEKLCEAFV TYPDLLILTH GQLELLGAGL RWKQRQSVQL
ALKCMKQLMS DSFSSDINNA AGTFILKMEN QLTRIMDSYK SSESAILHLF LEALSTVGNI
PLCEETAEKI IHKMFNPDEA VVNAAIDLHG IYHAAIHPSA EVETNALIAI LDVYERYAYP
LASFEAVIKK LWIKGFFRKL DELFQMLLDA MDTPANAGFI ASCIAHTISY CHRLLMEDIR
MKISPSSDNV NWSFMRKRMQ SFVSNYPKCL NAASRTPNIY NLLLNCMSPA NNELYRFAEV
DCEAYHEEVL FNILSKVALD ECSYPVLFQT LTTIYSFDTI AHISEDVWNE LTEKYYTFFF
HTRSRLRSYN LGIDKKLMES YSNAITRLCV LIEINNTSEH VFTLAEYLAN DLRLLPKMNL
SDESIGIFYR LYKNALYAVV QCCLAALPSD NPTAGIKYDQ LGKRVQAFMG VLVEQLDGGQ
QSPFAVSSHV ANALCNMLIL TQETTEPSQQ TGSIKQHMMY RVEPEVLAKL SAYIEQHVFG
GSVESALKEQ HSCVPKSAKY QTALQFSKMR EIVHLQTGQC GNQIGAKFWE VISNEHGIDA
TGAFQGDCGD LQLERINVYY NEASGGKYVP RAILVDLEPG TMDSVRSGPY GQLFRPDNFA
FGQSGAGNNW AKGHYTEGAE LVDSVLDIVR KEAEGCDCLQ GFQLTHSLGG GTGSGMGTLL
ISKIREEYPD RIMNTFSIVP SPKVSDTVVE PYNATLSVHQ LIENTDETYC IDNEALYDIC
FRTLKLTTPT YSDLNHLVSA AMSGVTTCLR FPGQLNADLR KLAVNMVPFP RLHFFMTGFA
PLTSRGAQQY RALTVPELTQ QMFDAKNMMA ACDPRHGRYL TVAAIFRGRM SMKEVDEQMM
NVQTKNSSYF VEWIPNNVKT AVCDIPPRGL KMSSTFVGNS TAIQEIFKRI AEQFTAMFRR
KAFLHWYTGE GMDEMEFTEA ESNMNDLVSE YQQYQEATAD DEGEMDEEEE GGED
//
