ID A0A182U9B0_9DIPT Unreviewed; 690 AA.
AC A0A182U9B0;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Lipase maturation factor {ECO:0000256|RuleBase:RU361229};
OS Anopheles melas.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC016294-PA, ECO:0000313|Proteomes:UP000075902};
RN [1] {ECO:0000313|Proteomes:UP000075902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEC016294-PA}
RP IDENTIFICATION.
RC STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC016294-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Involved in the maturation of specific proteins in the
CC endoplasmic reticulum. {ECO:0000256|RuleBase:RU361229}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU361229}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC ECO:0000256|RuleBase:RU361229}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the lipase maturation factor family.
CC {ECO:0000256|ARBA:ARBA00005512, ECO:0000256|RuleBase:RU361229}.
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DR AlphaFoldDB; A0A182U9B0; -.
DR STRING; 34690.A0A182U9B0; -.
DR EnsemblMetazoa; AMEC016294-RA; AMEC016294-PA; AMEC016294.
DR VEuPathDB; VectorBase:AMEC016294; -.
DR Proteomes; UP000075902; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051604; P:protein maturation; IEA:InterPro.
DR InterPro; IPR009613; LMF.
DR PANTHER; PTHR14463; LIPASE MATURATION FACTOR; 1.
DR PANTHER; PTHR14463:SF5; LIPASE MATURATION FACTOR 2; 1.
DR Pfam; PF06762; LMF1; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU361229};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361229};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361229};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361229}.
FT TRANSMEM 31..48
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361229"
FT TRANSMEM 93..110
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361229"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361229"
FT TRANSMEM 143..161
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361229"
FT TRANSMEM 173..199
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361229"
FT TRANSMEM 227..248
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361229"
FT TRANSMEM 335..355
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361229"
FT TRANSMEM 420..441
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361229"
FT TRANSMEM 652..674
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361229"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 690 AA; 78384 MW; E699412D78DF92E2 CRC64;
MEQAKARSDK NHEQRPQHEE EIGDVPRVRN LLLRSMCAVY LMAFVSFYCQ AEGLYGDGGI
LPASRILANG TLKERLSLLQ LAPFVGLGHG HEAIDLLCLV GATVAFLGLI SRAHCRLVSF
IVMWSVYFSL VQIAQSFRQQ ADHLLLEAGF LCILLAPTRL TDRRHPMEAI ALLLLKWLVF
RFMFASGSVK LASGCPLWWS LDGLKRHYET MPLPTSYSWY TYQLPDAFHR LSTIYVYLSE
LVVPWLFFAP SRTVRRFAVW WHVFLHLNII GCGNYGFLSP LVLTLLVTLL DDEDELVVWV
QDRLAVDDTR RRAGRGRTAA RNSADDSADR YGGRLVKAIS LLMVVGSWLC FSAGVSKDDG
QLTFQPTFTQ DQYLNVMQTM VRAAPLLVFV LLVKQFLKLL SSQDSVGSLA EGMRQFSKNL
GLLISTIVAF TVFFMSIVPH SRLLPSTAVT SPVMTRAYGG LHSLYVVNQY GRHLTKMRSM
RREIILEYGD DLNGTWHEYG FQYKPWTVER GASLSYGWLH FPRFDFKFYD AAGSKSDAQK
WIYPLVQRLL DHQQPVLDLL DSRNVPAEAP RYVRTSLYRF AYTSFADAAA GGFWTRERLT
DYFNVFSRED AHLRDKLRQM NFRTAAEQSS SGGGGGSWNW LLRWLLDAVR RFVGAIEGSY
LLIGLFVAAG MVLYTQQQQQ QQQQRVGPST
//
