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Database: UniProt
Entry: A0A182UAA6_9DIPT
LinkDB: A0A182UAA6_9DIPT
Original site: A0A182UAA6_9DIPT 
ID   A0A182UAA6_9DIPT        Unreviewed;      1139 AA.
AC   A0A182UAA6;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=Alpha-mannosidase {ECO:0000256|RuleBase:RU361199};
DE            EC=3.2.1.- {ECO:0000256|RuleBase:RU361199};
OS   Anopheles melas.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC016781-PA, ECO:0000313|Proteomes:UP000075902};
RN   [1] {ECO:0000313|Proteomes:UP000075902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AMEC016781-PA}
RP   IDENTIFICATION.
RC   STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC016781-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361199};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361199};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792, ECO:0000256|RuleBase:RU361199}.
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DR   AlphaFoldDB; A0A182UAA6; -.
DR   STRING; 34690.A0A182UAA6; -.
DR   EnsemblMetazoa; AMEC016781-RA; AMEC016781-PA; AMEC016781.
DR   VEuPathDB; VectorBase:AMEC016781; -.
DR   Proteomes; UP000075902; Unassembled WGS sequence.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   CDD; cd10809; GH38N_AMII_GMII_SfManIII_like; 1.
DR   Gene3D; 2.60.40.1360; -; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR   InterPro; IPR041566; AManII_C.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   InterPro; IPR048534; Man2a1-like_dom.
DR   PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR   PANTHER; PTHR11607:SF3; ALPHA-MANNOSIDASE 2-RELATED; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF18230; Glyc_hyd_38C_2; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   Pfam; PF21260; Laman-like_dom; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361199};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361199};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU361199};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361199}.
FT   DOMAIN          498..578
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
FT   COILED          40..67
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1139 AA;  130150 MW;  59B775E9F4C00AA3 CRC64;
     MVRIRRKFAF ILCGVTLFVF LILYVVLNYS VPERARVQDI TYLENKIKQL ENGLSKHRQE
     FGDIRKQIDT IRGAVDGGDD AYADSKILDK APLLGDREMM KESVINANGG GAGTCALRTD
     IIPQPDVQML NLYEQVSFEN IDGGVWKQGW PIKYHPSEWN SHHKLHVFVV PHSHNDPGWI
     QTFDEYYERS TKNIFANMLR HLDENAGMRF IWAEISYFAQ WYDKLVAEQK DIVKRLVKKR
     QLEFVTGGWV MPDEANSHWY SMLLQLTEGQ TWLQTRLNVT PVSSWSIDPF GQSATMPYIL
     KQSGFENLLI QRTHYIVKKN LALKKQLEFR WRQLWDTRGD TDLFTHMMPF YSYDVPHTCG
     PDPKICCQFD FKRLPSMGLS CPWNVPPKPI TDQNVAERAE MIVDQWRKKS VLYRTRNVLI
     PLGDDFRYTT SSEWEAQRVN FEQLFNYINN EPSLNVEAKF ATLQDYFDAV RATSGSSGME
     QFPSLTGDFF TYADVNQDYW SGYFTSRPYH KRQDRILLHY IRSAEMLHAW NVWEPDSDWK
     PLAERLEYAR RQLSLFQHHD GITGTAKDHV MEDYAKRMSR AIEDCKFVMQ QSVYRLLTKP
     SVYQPDPAFM YLSIDDSRTV NGSDNVRPTI ILGEELPSKQ VVLHNSLPYT RSEVVEFYVA
     SPFVTVLDGN GGTVPSQIAP VWSWHTRPDS ISQPQPSNTK YRLLFRANVP PLGLSVYTIN
     SKNNAEESLG VTYTKVIILS KSPFTVNLAA GYPEDIDHAS PTEMSLRFEE GGSTSAAFTS
     KGLLKSLTIE NNQATVPVHL EFYRYGMQLS SGKSGAYLFH PAGNATLMTY DQPIVLVMKG
     PLETSITAGL PFAVHQTILR DDSVEIRNLV DIGQRDNTEI VMRLQTNINS GATFYTDLNG
     MQIIKRKRFQ KLPIQANYYP VPSTMFIEDD NYRLTLLGGQ PLGGSSLSSG EMEIMQDRRL
     TRDDDRGLGQ GVQDNLPVLH LFRLVLESRE SCTKPDPDYP TGFLTLPAHA QLQSLLHPLD
     KLIYNENDWT GVQMEGFGSR HEPLEQGLEV VAIRQLSHVH FGRTSGALPV GLIVHRTNFE
     DCGSEANMEG MLNIKKLLNL DDEHDIYSAR LTLLKPLELV PSDDISLCPM DVKAYIVKR
//
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