ID A0A182UAP4_9DIPT Unreviewed; 1763 AA.
AC A0A182UAP4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=SEC7 domain-containing protein {ECO:0000259|PROSITE:PS50190};
OS Anopheles melas.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC016981-PA, ECO:0000313|Proteomes:UP000075902};
RN [1] {ECO:0000313|Proteomes:UP000075902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEC016981-PA}
RP IDENTIFICATION.
RC STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC016981-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR STRING; 34690.A0A182UAP4; -.
DR EnsemblMetazoa; AMEC016981-RA; AMEC016981-PA; AMEC016981.
DR VEuPathDB; VectorBase:AMEC016981; -.
DR Proteomes; UP000075902; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032629; DCB_dom.
DR InterPro; IPR015403; Mon2/Sec7/BIG1-like_HDS.
DR InterPro; IPR032691; Mon2/Sec7/BIG1-like_HUS.
DR InterPro; IPR046455; Sec7/BIG1-like_C.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF375; LD29171P; 1.
DR Pfam; PF20252; BIG2_C; 1.
DR Pfam; PF16213; DCB; 1.
DR Pfam; PF01369; Sec7; 1.
DR Pfam; PF09324; Sec7-like_HDS; 1.
DR Pfam; PF12783; Sec7-like_HUS; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 613..802
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 542..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1445..1496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..605
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1446..1460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1763 AA; 195818 MW; AB3D44791F0561D9 CRC64;
DIKEELKQAG HTDTNGETPV PSAALPLPKN DSGNIINAEK YFLPFELACQ SRTPRIVVTA
LDCLQKLIAY GHLTGNIPDS SNPGKFLIDR IVTTICNCFM GPQTDEGVQL QIIKALLTVV
TSQHVEVHEG TVLQGVRTCY DIYLSSKNLI NQTTARATLT QMLNVIFTRM EHQAFEAIAA
ANSSAGTAAG SNSSTTLQGA SPNVSATGTT VGQDESPTKP AEAEKHPDYD AVRVIVEEIV
DSVIAQAAAV NGAQESEHTV DGVGLTSSVS EPAINHHETS ETASIGGISN GATDTTSIAR
VPSQESMEVT SENDSIVTAK FTHILQKDAF LVFRALCKLS MKPLPEGHPD PKSHELRSKI
LSLHLLLSIL QNAGPVFRSN EMFIMAIKQY LCVALSKNGG SAVPEVFELS LSIFVALLSN
FKTHLKKQIE VFFKEIFLNI LEAPSSSFEH KWMVIQALTR ICADAQSVVD IYVNYDCDFS
AANLFERLVN DLSKIGQGRQ ALELGTSVNQ EKSMRIRGLE CLVSILKCMV EWSKDLYVNP
NSQTTLGDPP SGGIGAVERK GSSLNTSVGS PVDEPSSHEM ALKSHGGSSV SINSLGSTNT
SGGNREVLDL PEELEERKQR KEVMETGIDM FNRKPKKGIA FLQERGLLGT TVQDVARWLH
EDERLDKTQI GDYLGENDEQ SKSVMCGYID AMNFAELDIV AALRYFLEGF RLPGEAQKID
RLMEKFASRY CDCNPNNTLF ASADTVYVLA FSVIMLTTDL HSPQVKHKMT KEQYIKMNRG
ISDNKDLPEE YLSQIYDEIA GHEIKMKSTV ANKPAGKQII VNEKKRKLLW NLEMEALSTT
AKNLMESVSH VKASFTSAKH LEHVRPMFKM AWTSFLAAFS VGLQDCDDPE IASLCLDGIR
CAVRIACIFH MSLERDAYVQ ALARFTLLTA NSPINEMKAK NIDTIKTLIM VAHTDGNYLG
SSWLDIVKCI SHLELAQLIG TGVRPEFLSG PASHRDTLDP SAKEHIGETS SQSIVVAVDR
IFTGSIRLDG DAIVDFVKAL CQVSLDELTR PQPRMFSLQK IVEISYYNMG RIRLQWSRIW
QILGEHFNAV GCNTNEEIAF FALDSLRQLS MKFIEKGEFT NFRFQKDFLR PFEHIMKKNN
SPAIRDMVVR CVAQMVNSQA HNIKSGWKNI FSVFHLAAGD HDEAIVELAF LTTGKIITEL
YQSQFHIMID SFQDAVKCLS EFACNARFPD TSMEAIRLVR TCAICVNDSP NLFAEHAGME
NDVSVPEEDR VWVRGWFPML FSLSCVVNRC KLDVRTRGLT VLFEIVKTHG DAFRANWWRD
LFNVLFRIFD NMKLPEHQPE KAEWMTTTCN HALYAIIDVF TQYFDVLGPM LLADLYCQLH
WCVQQNNEQL ARSGTNCLEN LVISNGLKFS EDTWSKTCQC MLDIFNSTLP NELLTWKPDP
LPQSIGGGVA QTNQAASPRV QENGDLPRHG ILKRSGSQHS MHGQDGHGGA GEQGGVTAGS
AANTSVLFSN LLIKCVVQLE LIQTIDNIVF FPATSRKEDA ETLAQATAEL SAIHQQHASS
YPSSLSGEEC QREEQGMYSY LNTPHLLQLV DCLLQSHRFA KQFNSNNDQR TVLWKAGFKG
SLKPNLLKQE TQSLACVLRI LFKMYSDENR RRDWQDIEKR LIGVCTEALD YFLSLPSEPH
RDAWTSLLLL VMTRLLKMSD ARFAAHIASY YVFLCDLTCV DLKPELRTVL RRVFLRISPV
FGISSASASG ANGNSSTVPM AAT
//
