ID   A0A182UAS9_9DIPT        Unreviewed;       890 AA.
AC   A0A182UAS9;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Doublecortin domain-containing protein {ECO:0000259|PROSITE:PS50309};
OS   Anopheles melas.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC017036-PA, ECO:0000313|Proteomes:UP000075902};
RN   [1] {ECO:0000313|Proteomes:UP000075902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AMEC017036-PA}
RP   IDENTIFICATION.
RC   STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC017036-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC       microtubules are slightly longer, but more dynamic.
CC       {ECO:0000256|ARBA:ARBA00003210}.
CC   -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC       {ECO:0000256|ARBA:ARBA00006489}.
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DR   AlphaFoldDB; A0A182UAS9; -.
DR   STRING; 34690.A0A182UAS9; -.
DR   EnsemblMetazoa; AMEC017036-RA; AMEC017036-PA; AMEC017036.
DR   VEuPathDB; VectorBase:AMEC017036; -.
DR   Proteomes; UP000075902; Unassembled WGS sequence.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   Gene3D; 3.10.20.230; Doublecortin domain; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR024977; Apc4-like_WD40_dom.
DR   InterPro; IPR003533; Doublecortin_dom.
DR   InterPro; IPR036572; Doublecortin_dom_sf.
DR   InterPro; IPR005108; HELP.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR13720:SF55; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE CG42247; 1.
DR   PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF03451; HELP; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 9.
DR   SUPFAM; SSF89837; Doublecortin (DC); 1.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR   PROSITE; PS50309; DC; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT   DOMAIN          110..193
FT                   /note="Doublecortin"
FT                   /evidence="ECO:0000259|PROSITE:PS50309"
FT   REPEAT          522..554
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          611..642
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REGION          190..231
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   890 AA;  98578 MW;  1E3E6EC4ED62B966 CRC64;
     MFDSEEESAF VILTAPMYHP HHYGGGGIGG IYSQWNVSSG TRHGTGKHFR GGWENLEPPA
     SYGKKNGVWY ASPGNQGWGS GAGPARLGRK PSVTEVDNMP SGSLKPSAGR VIRIINSHDH
     SVQCRVLLNL RTSQPFEEVL EDLGQVLKMI GAKKMYTSNG QEVRSFSQLR NEFAEVETFY
     LSNTPSLPVG ALGPGVIPPS PGRRSRSRLG GSVPDDLSKT TARQRARSKS RPRVLYAPEN
     ELVRASSDYP LLDAMKEEPT RITIRGLRRT FYPPLHHPPI DNAPPDKKLS LFWVHGYRGI
     DSKRNLWVLP SGELLYYVAA VAVLYDREED AQRHYTGHTE DIMCMEVHPS RELVGSGQRA
     GRDRKSQAHV RIWSTESLQT LYVFGMGELD SGVIAVAFSQ LNGGSYILAV DAGRESILSV
     WQWQWGHLLG KVATLQEGIW GATFHPLDDN LLITHGRGHL AFWHRRKDGF FEKTDIIKPP
     SRTFVTCVQF EPDGDVITAD SDGFITIYSV DADGAYFVRM EFEAHNKAIS CLVMLSEGTL
     ISGGEKDRKI AAWDSLQNYK RITDIKLPES AGGVRSIYPQ RPGRNDGNIY VGTTRNNILE
     GSLQRRFNQV IFGHGKHLWA LAAHPDDEVF ATGGHDKYVA LWRRQKLIWT TSVGYEIIAL
     AFHPYGAALA AGSSEGHLIV INAENGATML TIRVCGSPLN AVEFNQVGDM IAIGSQNGSI
     YLFRVSRDGF SYKKINKIRG SQPLTHLDWS SEGNFLQSVT VDFDLLFWDV KSLSPEKSPI
     AMKDVKWMTS NCTVGFLVAG LWNNRYYPAP SNTIITTTAR TAAQDLVAAG DADGYLRLFR
     YPCITPRAEF TEAKVYSGTL AAVKFLYGNH SLVTVGGTDA SLMIWELTEE
//