ID A0A182UBY8_9DIPT Unreviewed; 1377 AA.
AC A0A182UBY8;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
OS Anopheles melas.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC017638-PA, ECO:0000313|Proteomes:UP000075902};
RN [1] {ECO:0000313|Proteomes:UP000075902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEC017638-PA}
RP IDENTIFICATION.
RC STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC017638-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR STRING; 34690.A0A182UBY8; -.
DR EnsemblMetazoa; AMEC017638-RA; AMEC017638-PA; AMEC017638.
DR VEuPathDB; VectorBase:AMEC017638; -.
DR Proteomes; UP000075902; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:UniProt.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.30.70.1390; ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR032171; COR.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020859; ROC_dom.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF26; NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF16095; COR; 1.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF08477; Roc; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00364; LRR_BAC; 8.
DR SMART; SM00369; LRR_TYP; 8.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS51424; ROC; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022777}.
FT REPEAT 52..78
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 288..320
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1018..1234
FT /note="Roc"
FT /evidence="ECO:0000259|PROSITE:PS51424"
FT REGION 209..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 794..859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 829..859
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1377 AA; 149982 MW; 58C922E46CD52DF2 CRC64;
MDPVDHTREQ IRSQKHRALR EAVTATDEAA VQLLLESIGS DREIIVNMAP GGANTLLFIA
AQAGSERIVQ LLLEAGADGR AHAVTKYSPL YTAVHNGHTQ VAALLLDRFP ELVQQVTVER
WLPFHAACIN GHCAVVELLI KHPYVEELLG VYRSPNGELE WRLPFDPNAQ DVAGQTALYV
GCLLGNPQLV ETLLKWRVKC VRHTLASTTD HEQAKMGGSG GRDHGGGGGS SSSNPLSPTS
RKISFGIQSI MSRLSLSGGR TDPSEEGEEG QLGEMRCPLD LDILCGAARE TALLAAVRGG
FLDVVTILLE NGADPNVIAR AVEDQNDPKS SDEIYGFSNV PLAEATRQKS LPMVELLLKH
GARDDQSVAL GIAVQNGDEP IICRLLAIKA HPDPDYKINK RALAGQEASA PEYGTAPLAF
VGKLGGSFTY SSLFPSTATM INWHSNNCRL GLIRMAWVSE AVLQCNRKLR AHPKCHQLAL
AALTRIDISH NTLTTLPAEL FALGSLRYLN AAQNKIERLP LPDEDAGGQG KRRGSAKPVD
YQCPVLEELY LQDNRLECVP AVLFRLPNLA ILDVSNNKLQ ELPFEMWKAP KLKELNVAFN
FLKDLPSLPL PELLLSCGQG QGGDGGRLEL PSPVTIAVEG GGGGGGGCGS SAAAAAMFHP
YTGTSASFDD GTEALARNRH VTNLELVRHH IWARSLEVTE QELRLADARH DSALSQLSSL
NLANNLFTSI PLALPCLAVN LTRLNMSYNS LRSMGHVTSY PASLKQLDLG HNEISCWPSL
PRIAASDPHL MCYNPQEGKK HPTDSGGGSG GVGAGTGGGS GGKSGSRGGS GGGDTTPSSN
ASTTSYGGTE MTTVVKSSTS SNSITSLRTA VLKSVCCHRR HLRLESLRTL VLADNSLTRI
QLSTDDVTTL GESDDAEWSL IGMAKSRLIF PNLSMLDISN NCLKEIPASI HELTNLSVLN
LSGNMDITEL PPHMGLLSRL WNLNTRGCSL QDPLRSMIDS KKYKTMDIVG YLKSVYEDAR
PYARMKLMVV GVQGIGKTSL LEQLRAEGSA RGKKPVDHWA KRMGHRHINQ KTSRGINMST
VGVDIGDWVC EKKVRGQSHH GPVVFRTWDF GGQREYYATH QYFLSKRSLY LVLWRIIDGR
RGLAEVLQWL GNIQARAPNS PVIIVGTHYD AVGETLPAKK AEELQQIIRD RFIAVSDAEK
IGLPRVLDSI EVSCRTGHNI KLLAGLIYDT AFSLRPPGCK EPLLYQRVPA SYLALEDVVA
NIAASLRQHG ADPVLDADRY RQTVTHEMQL RGLKGFRDWS ELNQATMFLH DNGVLLHYDD
ATLRDLYFLD PQWLCDMLAH VVTVREINPF ARTGVMKMDD LQHVFKSSCL GSNNNRG
//