ID A0A182UEG0_9DIPT Unreviewed; 780 AA.
AC A0A182UEG0;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Importin N-terminal domain-containing protein {ECO:0000259|SMART:SM00913};
OS Anopheles melas.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC018907-PA, ECO:0000313|Proteomes:UP000075902};
RN [1] {ECO:0000313|Proteomes:UP000075902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEC018907-PA}
RP IDENTIFICATION.
RC STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC018907-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the importin beta family. Importin beta-2
CC subfamily. {ECO:0000256|ARBA:ARBA00038423}.
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DR AlphaFoldDB; A0A182UEG0; -.
DR STRING; 34690.A0A182UEG0; -.
DR EnsemblMetazoa; AMEC018907-RA; AMEC018907-PA; AMEC018907.
DR VEuPathDB; VectorBase:AMEC018907; -.
DR Proteomes; UP000075902; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040122; Importin_beta.
DR PANTHER; PTHR10527:SF3; FI21453P1-RELATED; 1.
DR PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR Pfam; PF02985; HEAT; 1.
DR Pfam; PF13513; HEAT_EZ; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..780
FT /note="Importin N-terminal domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008138070"
FT DOMAIN 24..92
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|SMART:SM00913"
FT REGION 322..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..370
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 780 AA; 88320 MW; 0EEBD020E6D49C86 CRC64;
MLQLLNDQFP HRLLCFFLSF LFFFWQKLEE LNQYPDFNNY LIYVLTKLTS EDEPTRSLSG
LILKNNIRIH GTELQPAIIE YIKQECLMAL GDPSPLIRAT AGILITTIAN KGGLQNWPEL
LPTLCDMLDS QDYSVCEGAF GALQKICEDS ADVLDSSALN RPLNIMIPKF LQFFRHSSPK
IRSNAIACIN QFIINRTQAL MVHIDTFIEN LFHLSSDDDR EVRKNVCRGL VMLLDVRMDR
LMPHMNSIIE YMLIRTQDSD ETSLEACEFW LTLAEQSICK EVLTPHLPRL VPVLVRGMKY
SDIDIIILKG DVEEDEMIPD REEDIKPRFH KSRTHTQKPS LGGGASGADG AVRAMEGNDD
DEDIDDPYDE MDDDSNLSDW NLRKCSAAAL DVLANVFKDD FLPILLPILK ETLFHEEWVI
KESGILALGA IAEGCMNGMV PHLPELIPYL IVCLSDKKAL VRSITCWTLS RYAHWVVSQP
HDQYLKPLMK ELLKRILDAN KRVQEAACSA FATLEEEACT ELVPYLGFIL DTLVFAFRKY
QHKNLLILYD AIGTLADSVG HHLNKPEYIS MLMPPLIEKW NNLKDEDKDL FPLLECLSSV
ATALHSGFLP YSEPVYRRCI SLIQQTLNQD LASTTSPGQF EQPDKDFMIV ALDLLSGLAE
GLDCYIESLV SSSNIMQLLY QCMQDSMPEV RQSSFALLGD LTKACFQHVH PHIADFLPIL
GHNLNPEYIS VCNNATWAIG EISIKLMEDT KPYIPMVLAP LIEIINNTNT PKTLLENTGK
//