ID A0A182UIW9_9DIPT Unreviewed; 642 AA.
AC A0A182UIW9;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Fork-head domain-containing protein {ECO:0000259|PROSITE:PS50039};
OS Anopheles melas.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC021226-PA, ECO:0000313|Proteomes:UP000075902};
RN [1] {ECO:0000313|Proteomes:UP000075902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEC021226-PA}
RP IDENTIFICATION.
RC STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC021226-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR AlphaFoldDB; A0A182UIW9; -.
DR STRING; 34690.A0A182UIW9; -.
DR EnsemblMetazoa; AMEC021226-RA; AMEC021226-PA; AMEC021226.
DR VEuPathDB; VectorBase:AMEC021226; -.
DR Proteomes; UP000075902; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd20048; FH_FOXD4-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11829:SF405; FORK HEAD DOMAIN-CONTAINING PROTEIN FD3-RELATED; 1.
DR PANTHER; PTHR11829; FORKHEAD BOX PROTEIN; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089}.
FT DOMAIN 114..208
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 114..208
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 1..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..415
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..442
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..493
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..544
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..562
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 642 AA; 68371 MW; 41F125D0D6E1E135 CRC64;
MSVSPTHNAS LNESSTHSQQ QHYHAHQHLQ SMQSHQSHHH SQHQQAPSGQ RSGGASRNRS
RSTSSSDNGT PSSGQKAQQQ QQPDSDNGTE AGEGATSGGG GGKSGSHRSQ SLVKPPYSYI
ALITMAILQS PQKKLTLSGI CEFIMTRFPY YKEKFPAWQN SIRHNLSLND CFIKIPREPG
NPGKGNFWTL DPLAEDMFDN GSFLRRRKRY KRTTLAQSMA FPGVFAPFAP FWIRKPVPVI
PMHQFAPAHA AAAAAAASAS VGGFGGDGGP LGAALGPGRT GDFLLDSKLN LFGTVKIDDL
NVAMMENSDF LQRNVDSLKI SSAMNKFFHG YHQGQSGSSS GGGGGGGGGP LIDLYDDGPH
PASLGGVVHP CNGGLMREGM SYPYGGHKLA GISSSRIGEP ADPHADRRGD YGAEDEPISA
DLDLSSDDRI DVESEDDYKS PAERGATGTL TYHEMLLNGR KSTPMEPPPN STSPLPPPPP
PPPQPPVPAA HPSPTIEPSG DYSPHCSPSR MARDSDDYYI EEDEQSEKGS SSSSGSSSVG
GSLEESHPQF GKERRQHHHT HFYTELQPSG LVSGAGEQPL HGRVVPSANG THPTDAGASP
GYGETTKLFD GTESSFASRK RKYGNTKGFS IENLIGCSVE DG
//
