ID   A0A182UIY7_9DIPT        Unreviewed;      1285 AA.
AC   A0A182UIY7;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=carboxylesterase {ECO:0000256|ARBA:ARBA00039155};
DE            EC=3.1.1.1 {ECO:0000256|ARBA:ARBA00039155};
OS   Anopheles melas.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC021249-PA, ECO:0000313|Proteomes:UP000075902};
RN   [1] {ECO:0000313|Proteomes:UP000075902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AMEC021249-PA}
RP   IDENTIFICATION.
RC   STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC021249-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC       {ECO:0000256|ARBA:ARBA00005964}.
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DR   STRING; 34690.A0A182UIY7; -.
DR   EnsemblMetazoa; AMEC021249-RA; AMEC021249-PA; AMEC021249.
DR   VEuPathDB; VectorBase:AMEC021249; -.
DR   Proteomes; UP000075902; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 4.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002018; CarbesteraseB.
DR   InterPro; IPR019826; Carboxylesterase_B_AS.
DR   InterPro; IPR019819; Carboxylesterase_B_CS.
DR   PANTHER; PTHR11559; CARBOXYLESTERASE; 1.
DR   PANTHER; PTHR11559:SF370; CARBOXYLIC ESTER HYDROLASE-RELATED; 1.
DR   Pfam; PF00135; COesterase; 3.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 3.
DR   PROSITE; PS00122; CARBOXYLESTERASE_B_1; 3.
DR   PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Serine esterase {ECO:0000256|ARBA:ARBA00022487};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           17..1285
FT                   /note="carboxylesterase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5008138224"
FT   DOMAIN          21..493
FT                   /note="Carboxylesterase type B"
FT                   /evidence="ECO:0000259|Pfam:PF00135"
FT   DOMAIN          546..915
FT                   /note="Carboxylesterase type B"
FT                   /evidence="ECO:0000259|Pfam:PF00135"
FT   DOMAIN          920..1136
FT                   /note="Carboxylesterase type B"
FT                   /evidence="ECO:0000259|Pfam:PF00135"
SQ   SEQUENCE   1285 AA;  144034 MW;  0F7D2FBCB5693349 CRC64;
     MKLLVIFGAI LVTVGGQLKH PRVCTDDGCL LGTSMTDTKN LRFDAFVGIP YAKPPVGKLR
     FKKPIPIEPW TEDYNATESK PACLQKSFLL PGQPIVGDEN CLYLNVYRPK GNGSAVPLPV
     MVFIHGGGYF FGSADPQLYG PERILARKQV ILVTLQYRLG VLGFLSTGDA HATGNYGMLD
     QVLALRWVNR HISAFGGDPH SVTLFGESAG GASVQLHMMS PLSVGLFQRA IIMSGSALAV
     WSLPIQDPLT LARKQAKLVG VSEADELTTA ELVDVLQYLD AKVLTASMPH LRTWFEHPIV
     MYRPTVQGAS VPSEERFLPD DPRKLWAEGR YVDIPIMIGT VPNEGAVVSL AIVHNETIVE
     QFNENLKELL VPVLAINATD SVLEQLKGRY FPKAANNRWI KEDNADQFTK YANSNQTSCR
     DTTLYSFEFE GRHSFSSLYI QSNASHGVCH QDELLYLFRM IDLFPDFPPD SPETEMCNAW
     TEFLVNFASN GTRPDSSRSC EANNIQTVTF GNAKSSPEST SAASAVLVSS GNGLDVEMER
     MHEFWTQTEQ RDPARLMTSR RVIVVTFQYR LGVFGFFSTG DRSAPGNFGM KDQVMALRWV
     KKNIRAFGGD PNLVTIFGES AGGSSVQFQM ISPLSRGLFH RAVSMSGSAI SSWSVPIENP
     LILARAQAKV LGIVDASELS TEELVEQLRE VDAVELTRST ERLKLWDIHP ITLYHPVVEP
     PEEPEPFLAE DPRAAWRRGA YATVPWMTGS IPNDGSIITQ TIYRNDSLVE DLNSKFVNLL
     PLILRTSITK EKLARLRKRF LKNTPPSKWI TKNNYAELTK LMSEAWFLYP TVRSIKQHHA
     SRKHTPTSVY SFQFRGRYSF SKLFTGTDTP YGISHLDEMI YLFRMPLFFP EFPPGSPEAE
     MTQLWVKFFV DFATHDIVDK NPQPNDPWQG KYNASTTKSA CIQIVTVLPS PRLYGSEDCL
     YLNVFMPTLK IREAALLPVM VYIQGGGFLY GSAQLEQRNP ARFMTWSRVI VVTFQYRLGV
     FGFLSTGDRS APGNFGMKDQ VMVLRWVKKN IRAFGGDPNR VTIFGESAGG SSVQYQMISP
     LSRGLFHRAI SMGGSDFNSL KAAIGSPLAF ARAQANVVGI ENANELSSAE LVEELRKLFS
     EAYFQYPMVK NIKQHLANRK NTSTSVYSFQ FRGRYSFSTL FTGSDKQYGI SYLDELIYLF
     RMPLFFPEFP PGSPEAEMAQ LWVKFFVDFA TQESVDKIGT CYGEKCEVVT FANSNNRYFL
     VNKKLVPGLD EEMYRFWKGF YEVKA
//