ID A0A182UJY1_9DIPT Unreviewed; 606 AA.
AC A0A182UJY1;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=[histone H4]-lysine(20) N-methyltransferase {ECO:0000256|ARBA:ARBA00012187};
DE EC=2.1.1.361 {ECO:0000256|ARBA:ARBA00012187};
OS Anopheles melas.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC021762-PA, ECO:0000313|Proteomes:UP000075902};
RN [1] {ECO:0000313|Proteomes:UP000075902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEC021762-PA}
RP IDENTIFICATION.
RC STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC021762-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) +
CC N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:60344, Rhea:RHEA-COMP:15554, Rhea:RHEA-COMP:15555,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.361;
CC Evidence={ECO:0000256|ARBA:ARBA00000350};
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A182UJY1; -.
DR STRING; 34690.A0A182UJY1; -.
DR EnsemblMetazoa; AMEC021762-RA; AMEC021762-PA; AMEC021762.
DR VEuPathDB; VectorBase:AMEC021762; -.
DR Proteomes; UP000075902; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0140944; F:histone H4K20 monomethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd10528; SET_SETD8; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR016858; KMT5A-like.
DR InterPro; IPR047266; KMT5A-like_SET.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR46167; N-LYSINE METHYLTRANSFERASE KMT5A; 1.
DR PANTHER; PTHR46167:SF1; N-LYSINE METHYLTRANSFERASE KMT5A; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51571; SAM_MT43_PR_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 22..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 481..591
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 353..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..390
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 606 AA; 67780 MW; D4358CEA4AD143EC CRC64;
MVIFHEDINA RFFTTRLLTN NTVITCSLIL IVQFSNTLCR FIITGRRTRN AEKKNANPVH
DDTASPKRKD IKYTYEDSNN PVANIEQRNN TSVCDEPMKL RGGRVKMADI SKYLEKKNDS
NITEKSITLV QSKGNLDITD ENVCKIVKAQ LLEESISLSD TTVTRNNFVE PKKSKNNNIF
LQEPVLHLNF AKAANPSSRT LSLVQNSILT QQDMKTGLFT TPSQPKINSF WKEVTLTRNI
KGTNDEKERS SMSNNEQQIL DLSKPTQVTQ IDSTTTAENV LTDDDNSCDS GDSGVVILSG
TNGTITMSLT NNQTNLSACA EHIGEAENRK KPATPHRILC PSPTKNAIIY LQSPPGLLNN
SSSGKSRNKR QTDNNKTRKR LISKDAENGA AATEEIKEMK PEQLDDAANA ARDRAVPIEL
NKNIVQQNRK IVVGSANFKP GCIKKITEYY PIRRSVRKTK KEVQGERDRD IERAIKEGRE
DGLKIEYFEG KGRGIVTTRT FAKGEFVVEY IGDLISVAEA KQREQVYAKD DSTGCYIIDA
TAESGKLGRL VNHSRNGNLV TKTVPINNRP HLVLIAKEDI EKGVEVTYDY GDRSKEALLH
YPWLAL
//
