ID A0A182UMI1_ANOME Unreviewed; 1117 AA.
AC A0A182UMI1;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 13-SEP-2023, entry version 32.
DE RecName: Full=Diaphanous {ECO:0008006|Google:ProtNLM};
OS Anopheles merus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30066 {ECO:0000313|EnsemblMetazoa:AMEM000420-PA, ECO:0000313|Proteomes:UP000075903};
RN [1] {ECO:0000313|Proteomes:UP000075903}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MAF {ECO:0000313|Proteomes:UP000075903};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles merus MAF (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEM000420-PA}
RP IDENTIFICATION.
RC STRAIN=MAF {ECO:0000313|EnsemblMetazoa:AMEM000420-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the formin homology family. Diaphanous
CC subfamily. {ECO:0000256|ARBA:ARBA00008214}.
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DR AlphaFoldDB; A0A182UMI1; -.
DR STRING; 30066.A0A182UMI1; -.
DR EnsemblMetazoa; AMEM000420-RA; AMEM000420-PA; AMEM000420.
DR VEuPathDB; VectorBase:AMEM000420; -.
DR VEuPathDB; VectorBase:AMEM21_004346; -.
DR Proteomes; UP000075903; Unassembled WGS sequence.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.20.58.630; -; 1.
DR Gene3D; 6.10.30.30; -; 1.
DR Gene3D; 1.10.20.40; Formin, diaphanous GTPase-binding domain; 1.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014767; DAD_dom.
DR InterPro; IPR044933; DIA_GBD_sf.
DR InterPro; IPR010465; Drf_DAD.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45691; PROTEIN DIAPHANOUS; 1.
DR PANTHER; PTHR45691:SF6; PROTEIN DIAPHANOUS; 1.
DR Pfam; PF06345; Drf_DAD; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51231; DAD; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils}.
FT DOMAIN 76..449
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 627..1026
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT DOMAIN 1048..1078
FT /note="DAD"
FT /evidence="ECO:0000259|PROSITE:PS51231"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 522..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1011..1032
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1065..1117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 480..514
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 527..554
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..601
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1070..1092
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1093..1107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1117 AA; 124965 MW; 1FAA6D12E768F3A0 CRC64;
MSKHDRVKSG GFLDTLLGRP HKKLGRHGGS GVYGNGPSSA GGNGTGGYGS YGSLNGGRPL
SGPDADLASL IEPNETHRLS EAEVNKLFLE ILEDMNIPKD KRDPLLGKPL EEKRKMIDMH
VKGKISSEHR ANSRFEKPSD YVQYLHEGDY LNRTNKLLAC LESLRVALTS NPISWIKDFG
EDGINEIVSL LRYCKTVPRR MHKIEYECLR CLKAILNNSW GLNVILTPDQ HAVVLLLAQC
IDTTQPHTMC EAIKLLSALT LLKDRNGYEK VLRAITNVSS MRKPGAERFR PIVEGLLMDN
DRNYELTCST MIFINCIINT PTDINFRLHL RCEIMRAGLY ERIDQLSEMV DKCGNENLVN
HIKIFNSYRE EDFEEFSNRF DNVRLELDDM NDCFELLKNL VADTASEPYF LSILQHLLFI
RDDHQYRPAY FKLIEECVSQ IVLHKSGYDP NFDCRDFHID TSTLLDDMAE KTKQIESKKS
EDFEKRMTEL QTAKQEAEAR VAALEDRLKE IEATGVVVSP KGKSKLPQIT IPPPPPGLLP
GGGPPPPPPC PGAVPVMMGG GGGAPPPPPP PFPGAAAGGP PPPPPMPGMG GPPPPPPPMM
MMGMRPPGMP PPFPNAAPKP LPYGLKPKKK WDTDGPMKRA NWNGLDAKNL SENSFWVQVQ
EEQLADNDMF ARLALKFSSK PAKPIDKDAA DRPQSSKKNV DLRVLDAKAA QNLSILLGGS
LKHLSHEQIR TCLLRCDTSV LSPSVLQQLI QYLPPPDQLK RLQEIRARGE DLAGAERFAA
TIGDIKRLGA RLQSLSFKID LPDMVQDVKP DIVAGTAACE EVKKSKKFAK VLELILLLGN
YMNSGSKKDP AYGFEMSFLP KLSSTKDHEN KQTLLHYLAE VIESKFPDAL TFYEDLSHVD
KASRVSLDTI QKTMRQMNNA LKNLESDLNN NKVPQSEDDR FLEVMGQFAV ECRAQVEVLG
RMLAQMESLF GSLSEYYCFD PAKYTMEEFF TDIKTFKDAF VQAHADNCRL REEEEKKRRA
QEAKERSQRE LLERQQQRKV DLINIDAAQT QEGVMDSLLE ALQTGSAFGN REQRRRRGPR
PAGAERRAQL NRSRSRTGIT ASAFSSREML SELLGPA
//
