ID A0A182UT62_ANOME Unreviewed; 1120 AA.
AC A0A182UT62;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=MBD domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Anopheles merus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30066 {ECO:0000313|EnsemblMetazoa:AMEM003193-PA, ECO:0000313|Proteomes:UP000075903};
RN [1] {ECO:0000313|Proteomes:UP000075903}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MAF {ECO:0000313|Proteomes:UP000075903};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles merus MAF (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEM003193-PA}
RP IDENTIFICATION.
RC STRAIN=MAF {ECO:0000313|EnsemblMetazoa:AMEM003193-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A182UT62; -.
DR STRING; 30066.A0A182UT62; -.
DR EnsemblMetazoa; AMEM003193-RA; AMEM003193-PA; AMEM003193.
DR VEuPathDB; VectorBase:AMEM003193; -.
DR VEuPathDB; VectorBase:AMEM21_010807; -.
DR Proteomes; UP000075903; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0140034; F:methylation-dependent protein binding; IEA:UniProt.
DR CDD; cd20104; MBT_PHF20L1-like; 1.
DR CDD; cd01396; MeCP2_MBD; 1.
DR CDD; cd20386; Tudor_PHF20-like; 1.
DR Gene3D; 2.30.30.140; -; 2.
DR Gene3D; 6.20.210.20; THAP domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR008395; Agenet-like_dom.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR040477; KDM4-like_Tudor.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR043449; PHF20-like.
DR InterPro; IPR006612; THAP_Znf.
DR InterPro; IPR038441; THAP_Znf_sf.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR15856:SF51; MBD-R2; 1.
DR PANTHER; PTHR15856; PHD FINGER PROTEIN 20-RELATED; 1.
DR Pfam; PF05641; Agenet; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF20826; PHD_5; 1.
DR Pfam; PF05485; THAP; 1.
DR Pfam; PF18104; Tudor_2; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00980; THAP; 1.
DR SMART; SM00333; TUDOR; 1.
DR SMART; SM00355; ZnF_C2H2; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 2.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50950; ZF_THAP; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00309};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 1..85
FT /note="THAP-type"
FT /evidence="ECO:0000259|PROSITE:PS50950"
FT DOMAIN 453..524
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 569..594
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 91..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 621..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 676..794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 986..1034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..639
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..695
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 712..743
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..784
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 995..1029
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1120 AA; 123400 MW; 5783CC30B0E650B3 CRC64;
MGIRKCIVPE CPSSSARPED RGVTYHKIPY LDEMKRLWIV ACHLPDDYFA TKASNVCSRH
FRRADFQEFK GKKYVLKLGV VPTVFPWTVT KPPGEAASSS KSPQKTATKG KDDAKGAKAE
ETEEGEVPHE VGDMDGDIVV KEDAKVTALL KSEQAPKGMV TPDRSKPKAA APSKRPTSSK
KATKTPAKQA RTAEPVASST PNRKQTPKKG AGGEAKPATA STAKEEPVVP DEPEAGGAPE
KPIDFTPGSK IEAQDFSGIW HAAKVVEVDT EEREVLVQFD KTDKLKSTTQ EEWIPMDSVR
LRPISNAIYS VGEKVFARWS DSRKFKATIK SVLENQMYEV VFDDGFAKIC KSTHISRIKR
SEDAKGDGPE REVAGAGGAT EVGATVKPEP LEHGEGGEAA VESLVSLNQL RIPQVVKLSE
LPEIPQNGEW CCHWMNDYPV GESSEVDLPG GRVYTVIVPD WRMPEGWVKH IFQRITTYGK
MDILLISPSG KVLRSRQEVK AYLAEVGEEY DPNRYDFGLH VKRAKQLGFC HYTQEYRDSF
LPKPATEPVL LNTEVNIGAV KVKIIDNLFQ CPEEDCLKTF RKENHLQIHI KHYHKELAKG
LGDIPNMQDL AALRTPIELL ETPKPVSRKS QTAAAGATPK ASTAQPAPVR EEMREEEELL
PAEMWVESTV VMSDGKVEEA LKPPREIKQE AEKAPESEAS LMAMDTEASL AEESSADASS
TVTASTPASS SKSKGSSKVT KIKLFSQKKA AGEGGKKVVR HGLVTKKKAS GGSKKSKRPK
PSRRPAANRS APALLRPNDT TLAGSFAYGS GGFQNETVGG IYDESINASV AGTSGAAGGL
VDENGEVIKI VRMRKEEIIN CLCKVTEEDG LMVQCEMCLC WQHAFCQNIR HSSEVPDTYV
CSICRYPYRG RASKRYAHDQ DWLYEGKLPV AKYHVTNSRH AQRFDILKNS HTLTGNLLEL
KRFMHSLQMK INIAEKKDHP KMYLWSKKWE KSPPRGDGSS SSSAGGGADK SLQGDGATQQ
QQQQQLPQIP VPEAPIDPAE CQTILLDHIQ KLQNDAMGRL QAIEAQIIGL EAYDEKADLL
ESPTAKNYPK TKQTIHMLLN DLLKMKKIGE IHSDMHSLTM
//
