ID A0A182UU78_ANOME Unreviewed; 638 AA.
AC A0A182UU78;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:AMEM003727-PA};
OS Anopheles merus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30066 {ECO:0000313|EnsemblMetazoa:AMEM003727-PA, ECO:0000313|Proteomes:UP000075903};
RN [1] {ECO:0000313|Proteomes:UP000075903}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MAF {ECO:0000313|Proteomes:UP000075903};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles merus MAF (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEM003727-PA}
RP IDENTIFICATION.
RC STRAIN=MAF {ECO:0000313|EnsemblMetazoa:AMEM003727-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
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DR AlphaFoldDB; A0A182UU78; -.
DR STRING; 30066.A0A182UU78; -.
DR EnsemblMetazoa; AMEM003727-RA; AMEM003727-PA; AMEM003727.
DR VEuPathDB; VectorBase:AMEM003727; -.
DR VEuPathDB; VectorBase:AMEM21_002285; -.
DR Proteomes; UP000075903; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0050906; P:detection of stimulus involved in sensory perception; IEA:UniProt.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR PANTHER; PTHR42643; IONOTROPIC RECEPTOR 20A-RELATED; 1.
DR PANTHER; PTHR42643:SF24; IONOTROPIC RECEPTOR 31A, ISOFORM C-RELATED; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..638
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008138657"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 599..623
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 281..357
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|Pfam:PF10613"
FT DOMAIN 373..517
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00060"
SQ SEQUENCE 638 AA; 71756 MW; 395C182EE9E3646F CRC64;
MDKFPYLQFL VQCLIVLKVL TVSNGTPQAT AVNPLSSHTQ TDQRIAAVRD LLVHLDRAHQ
LLVLTCWSPS VRYALWQSVR ESTGTSHSGT ASVRFAPIDQ RHLPWHDPNQ HQIVIVLDLS
CPGTDRLLES ARQLLYYRVR WIVFRSSIEY PGGSVRGWSN CSEYSVLDRL PLLVSNELFY
FCTETSTGQH LVRQQYRLAA SLASSSAPIY ETFGTWNAAL GVRVVVGSKV RPPVTSIRRQ
NFHKFQLRAS LVILHNETLN HLDDLHDKHI DTISRVNYLL TKSVAHALNA TVKFSIVDTW
GYRDRETDRY NGMIGELQRD LADLGGTSMF FTQDRIKAVD FLSMTASTRA SFIFRAPKLS
FTNNVFVLPF DQYVWYCTVS FIVLSGVLLL VMLRTEQRYN AGGGGRGGSA IGSNSPATVT
GLSDTLLNVF GTTCQQGSFI EPQTAPSRCL ILLCLVVLMF LYASYSANIV ALIQSPSTKI
QTLEDLLASR LKTGAEDTGV ELIRQGHYAF HVERGVGYKL ISETFQEEEK CGLQEVEYLK
VIEPYYAVQK NSSFREPVRI NLFKLREFGI QGREHTLLYT KKPRCVGGSS FIPVSIVDVW
PALVTLGWGY LLTVAVLIAE LLWFRLRSRI LPTAGYFQ
//