ID A0A182UUX1_ANOME Unreviewed; 1957 AA.
AC A0A182UUX1;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Triple functional domain protein {ECO:0008006|Google:ProtNLM};
OS Anopheles merus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30066 {ECO:0000313|EnsemblMetazoa:AMEM004073-PA, ECO:0000313|Proteomes:UP000075903};
RN [1] {ECO:0000313|Proteomes:UP000075903}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MAF {ECO:0000313|Proteomes:UP000075903};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles merus MAF (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEM004073-PA}
RP IDENTIFICATION.
RC STRAIN=MAF {ECO:0000313|EnsemblMetazoa:AMEM004073-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR STRING; 30066.A0A182UUX1; -.
DR EnsemblMetazoa; AMEM004073-RA; AMEM004073-PA; AMEM004073.
DR VEuPathDB; VectorBase:AMEM004073; -.
DR VEuPathDB; VectorBase:AMEM21_013308; -.
DR Proteomes; UP000075903; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR CDD; cd13240; PH1_Kalirin_Trio_like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd00176; SPEC; 5.
DR Gene3D; 1.20.58.60; -; 4.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR047054; Kalirin_TRIO_PH_1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR22826:SF117; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 4B-RELATED; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00435; Spectrin; 4.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SMART; SM00150; SPEC; 5.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 6.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1346..1520
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1539..1646
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1814..1882
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1213..1250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1271..1308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1675..1703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1883..1922
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 583..638
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 669..717
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1277..1301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1684..1703
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1957 AA; 221008 MW; 600E7970EB0CA3AC CRC64;
MDGVRALDIL PLLNERFALL SGGRDNRGGP IICFPATTKR ERIKPEDIKR VVSYFINIPS
DESKSHGFTI IVDMRGNGNT AASAKMILKV LQENFGTDVI HQAVIIKPDN FWHKQRSSIA
SNKYKFETTT ISIQSLGKLV EPSQLTSDFE GFLHYDHAVW IDLRVAFEDF LWQASDILDR
IDDLQEDLTH SECPEDVNGA KHSIDAHNEM KRKILKLPIE DLDLQGQKLL GKLTTYSNRN
DDGCHSAPLP TNCINPDVTS AMNQVLQQLE TTRNAQQQLL NLWQHRKTKL DQCFQLRLFE
QDCEKMFDWI LHNRDVFQET YVEIGHNYAI AKNLQEEHQR FAITSRNVCV NINRILAVAA
RLYEGNHYAA AHIRTLAARL DKTWKDFVTT LDERTAVLTL SVVFHHKAEQ YTESVSSWAA
ACEATIPTPT NVESLETAIG THQSLYEAMC QAYTEVHSTS KKLLYQLDHL VQVCNQPPIV
NTRKNDNSHF NGGNPAADYS EGASHVLAVI HQILGHHRAL ESKWHAGKLR LHQKLALRLF
QEDVKQVLDW LQNHGDVFLR KNRGIGKSLQ KARIYQTSHE HFENVAQNTY RNAEKLLAAA
EELARSGEVS PQEIFSVAQE LETNVASFAE RVEKRRRRLD LAVVFYSNEK EISAWQEQLH
AEVTNEESLE LANEHLEGTE RMLEQCKEQE ENTLKTCMQA IAQGEALLQE LRAIEEEDSS
GSLTAVQNAL DRIQKNRLDL EGLWQTRRMK IDLYLRLRIF ERDALEVSSQ LEMWSEELQH
TEVSRDFQKT EQFLRLHNES VNQMQTTTYQ VMNQGHELMQ LFESSGLLIM ADANHTAQTR
VQCLLEFLHD RELDLEDMAE AKRIKLEQSM QLCHFQNDAN QVISWIRNGE AMLMANFSIP
NNFQEAEQLR KEHEQFQVAI ERTHTSAVQV KYRADALMNA NHYDPQSIKD IAEDVTKKWQ
KLVTCAEERH KLVTASQNFF KTAEQVCSVL DSLEKEYRRE EDWCGGGGST DKGQQIVQLI
SKHQEQKEAF LKACTLARRT AETFLKYANR SLQFYHVKPT TVNSESRVKS ILEKLLAQET
QVLEYWTQRK KRLDQCQQFV LFERSAKQAI EWIHDTGEAY LSSRKNKLCS SREESELLLR
EHNEFKSTAK ETRERVKLLI QLADTLVEKG HAHASSIKQW VATVDYRYKD FSQRMEIYRS
NLEKSLGLPG IIQQQDDNNL SSSNSSNNSS NSSLNAGRSL SSANSSSGIS SGSGSYASVI
AVGGASPVPA GGVPGGSNGD GSSSSSGPCS TSSTGTSAGS AGGSVLEYRH SDPSLETKLN
AAAAGAGAVG AVQKEINEEK RKSARKKEFI MAELLQTERT YVKDLETCIS VFLRELKSGQ
QVPPNLVGRE HILFANIEDI YQFHEKIFLR ELEKYETMPE DVGHCFVTWA TKFDMYVHYC
QNKPQSMDYM VQHGGTYFDE VQRKHKLEHS LPAYLIKPVQ RITKYQLLLK DLQSCCDEGR
GEIKDGLEVM LNVPKKANDV MHLSLLEQCD MPIDNLGDVV LQDSFLVWDT KQILIKKGRE
RHVFLFELYI LFSKEVKDTN GTVKYIYKNK LLTSDFGVTE HIEGDECKFA IWTGRAPILS
DYRIVLKANS LETKQLWVKR MREVMQETYF SGTSFSLLKS PAKVSGKNLG QRLSKDIDDT
LNDNDQDGSS LASFGSGNTT DSEKLSTTYN ALGVYRWAEA IVNIILLSDS TATSPATTIT
SSSSSSIAVQ QQIEQEYSAK GGGGGLSSTG STKKSGRKIS LPWFRQSSVP SHAALARQHT
IDSPGSFQFF RKGGLAEMTW VIADHTAAPG TSELSVSKGQ QVEIVDMNCS GAPDYCLVRL
SINASDSQEG LVPVTVLKPL PSSHSKLNNK QRDTDTLGEV PQESDCILPN QHTSPVNKRK
GFSGRDVPTF PALVRWDYSG VSLKRSSFTG QRMWIIP
//
