ID A0A182UV50_ANOME Unreviewed; 1154 AA.
AC A0A182UV50;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Ribosomal RNA adenine methylase transferase N-terminal domain-containing protein {ECO:0000259|SMART:SM00650};
OS Anopheles merus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30066 {ECO:0000313|EnsemblMetazoa:AMEM004186-PA, ECO:0000313|Proteomes:UP000075903};
RN [1] {ECO:0000313|Proteomes:UP000075903}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MAF {ECO:0000313|Proteomes:UP000075903};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles merus MAF (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEM004186-PA}
RP IDENTIFICATION.
RC STRAIN=MAF {ECO:0000313|EnsemblMetazoa:AMEM004186-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. rRNA adenine N(6)-methyltransferase family.
CC {ECO:0000256|PROSITE-ProRule:PRU01026}.
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DR AlphaFoldDB; A0A182UV50; -.
DR EnsemblMetazoa; AMEM004186-RA; AMEM004186-PA; AMEM004186.
DR VEuPathDB; VectorBase:AMEM004186; -.
DR VEuPathDB; VectorBase:AMEM21_009848; -.
DR Proteomes; UP000075903; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000179; F:rRNA (adenine-N6,N6-)-dimethyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.10.8.480; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR043987; CCZ1/INTU/HSP4_longin_1.
DR InterPro; IPR043989; CCZ1/INTU/HSP4_longin_3.
DR InterPro; IPR026091; HPS4.
DR InterPro; IPR001737; KsgA/Erm.
DR InterPro; IPR020596; rRNA_Ade_Mease_Trfase_CS.
DR InterPro; IPR020598; rRNA_Ade_methylase_Trfase_N.
DR InterPro; IPR011530; rRNA_adenine_dimethylase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR00755; ksgA; 1.
DR PANTHER; PTHR14407:SF9; HERMANSKY-PUDLAK SYNDROME 4 PROTEIN; 1.
DR PANTHER; PTHR14407; HERMANSKY-PUDLAK SYNDROME 4 PROTEIN LIGHT-EAR PROTEIN-RELATED; 1.
DR Pfam; PF19031; Intu_longin_1; 1.
DR Pfam; PF19033; Intu_longin_3; 1.
DR Pfam; PF00398; RrnaAD; 1.
DR SMART; SM00650; rADc; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS01131; RRNA_A_DIMETH; 1.
DR PROSITE; PS51689; SAM_RNA_A_N6_MT; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01026};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU01026}; rRNA processing {ECO:0000256|ARBA:ARBA00022552};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01026};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01026}.
FT DOMAIN 885..1054
FT /note="Ribosomal RNA adenine methylase transferase N-
FT terminal"
FT /evidence="ECO:0000259|SMART:SM00650"
FT REGION 457..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 539..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 609..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 878
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01026"
FT BINDING 880
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01026"
FT BINDING 905
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01026"
FT BINDING 926
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01026"
FT BINDING 954
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01026"
FT BINDING 969
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01026"
SQ SEQUENCE 1154 AA; 129163 MW; 0803DE7DB3685147 CRC64;
LAEMSKETMI IFVYDLTKKV ENDDPTGSII YFHPMWVSEL QKKSLCGQLM GSTYFLGETL
STVRFLSLQN GKFALRSHGR FMLAVGSDRN IAESILEYRA SLLSSLIELY HGDFNTLYNV
YVEKEQKNGF NEKVFCLMES TLPLLQFNGN ILQNMPLLRL PKCASNVYLE SNQILQSFLQ
NKGVLGGSIF YHNKVLASQL PTNLTKMFVY SDPYRMKLAE MIAVTFHVPN GVSLISAYIT
KRDYTQLIDA TKNIPIYFNN CATAAPPTGS VPFAIKKKLI PSKELGGTVS GFPMLKSDKS
IIFSNIPEEE TVGADGGLCE QTQSKKSFST VSRPTFLPLK FKNLTSRDII DSGVNSINFD
ESDSFPNFIG KTSVCSTPLT ENKIVPNRNM MSICVTQDQP SAPPAEENDN IGVEEEKPPI
AVEANGRSSL KYFNARKYSI LNNPFMMPKH IRCSSMSNLT EQQSNETEEN SPAEDTGGVD
RHIKNKRQFK FSNNYDPAKT ISDPLYPLVD QRKRAMSYSL FQDFERSRNE RIAELVEQEA
KQEPKGNDKC NQVTQQQPSA IDDRIPTVGA ISTTARKVEL PLSENPELVK GAATPKDRRA
LSLPIKSFNL NDDAPSTARA GGNGGTSSGQ ELFTRRKSTL ELTPLMTKLT VLALNDTESS
GVSSWDTTPG CSYNMAISPQ DYIPQRRKSQ DISQSVAPPL GVLAGDENAL VKVDLFVCVQ
QNMTLILVMQ EKNCKNQRLV QTLFESCVSK FLRIENDIQL AMNINVDGFD KTDGYSLIAL
DSDWDVAKKN GPWNALEMQT AESLHTHFKK SNIVTEVTLK SQETVLYGYQ CGMRELFYTQ
AANAQGGLPP PQDVMGSVPL CAKRRIERIV FNKDFGQHIL KNPLVITSML EKAALRPTDV
VLEIGPGTGN MTVKILEKVK KVVACEIDTR LVAELQKRVQ GTHMQPKLQI LIGDVLKTDL
PFFDICVANM PYQISSPFVF KLLLHRPFFR CAVLMFQREF AQRLVAKPGD KLYCRLSINT
QLLARVDMLM KVGKNNFKPP PKVESSVVRI EPRNPPPPIN YTEWDGLTRI AFLRKNKTLA
AAFKQTTVLT TLEENFKLHC SLKNIDVPAD LNVKEMVEKI LEKADASDKR ARSMDIDDFM
AVLQAFNAEG FHFS
//
