ID A0A182UVN0_ANOME Unreviewed; 1116 AA.
AC A0A182UVN0;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Echinoid {ECO:0008006|Google:ProtNLM};
OS Anopheles merus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30066 {ECO:0000313|EnsemblMetazoa:AMEM004442-PA, ECO:0000313|Proteomes:UP000075903};
RN [1] {ECO:0000313|Proteomes:UP000075903}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MAF {ECO:0000313|Proteomes:UP000075903};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles merus MAF (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEM004442-PA}
RP IDENTIFICATION.
RC STRAIN=MAF {ECO:0000313|EnsemblMetazoa:AMEM004442-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A182UVN0; -.
DR STRING; 30066.A0A182UVN0; -.
DR EnsemblMetazoa; AMEM004442-RA; AMEM004442-PA; AMEM004442.
DR VEuPathDB; VectorBase:AMEM004442; -.
DR VEuPathDB; VectorBase:AMEM21_003939; -.
DR Proteomes; UP000075903; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd00063; FN3; 1.
DR CDD; cd00096; Ig; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR11640:SF134; ECHINOID, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR11640; NEPHRIN; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF13895; Ig_2; 2.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 736..757
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..80
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 87..155
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 181..270
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 275..383
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 388..485
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 492..600
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 959..978
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 985..1005
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1018..1058
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1075..1105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 990..1004
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1036..1058
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1116 AA; 123168 MW; BE6E0C53E89FFDDF CRC64;
FPRVKVGPEN PLRVERDSTA VLECAVDSKP KVPNVRWTRN GRIISSSHSH PIQRVSVQDA
GNYACAADNG LGKIGEQIIT LDVLYAPIVV IESKTWEAEE RSTVTIRCNV TSNPPPVSIE
WFKEGSPDFR YAGDILQLRD VKAEHAGRYV CRAVNMMKPY NGKIVERVGN STVALLVRHR
PGQAYINPSK PIVHVGNGVT LTCSANPPGW PVPQFRWFKD AVGEQQTPKT ILAQGTQYVI
PRAHLGSEGS YHCHAVNEMG SGPMATINLE VHQPPQFIGK MQQHMTKRIG DTDFSATCHA
KGKPRPMVRW LKDGRDITTD ANMYRISTNN NDGLSGMVTV QSTLLFQGKA RPHKNQLLPS
DRGTYTCLFE NEVSTANASM NLRIEHGPIV LHQYNKVAYE INENAAVMCR VQAYPKPEFQ
WQLGTNTAAL SMSADEHYEI NTTTDNNDIY TSVLRINRVK HEDYGDYTCR VGNSIETIRA
PIRLQPKGPP EKPTNLGVAD VGSNYVSLVW DPGFDGGITN TKFFVSYRKV AIPHHDQVKE
DCGIVQQVSS EWMEYDCQRD VPCSVTPLDQ YQSYVFKVKA INSKGNSEPS NEVATTTKIS
KIPVPLHVGF DPDTKQLGLN IGATCLALIA VVETIGFHES PIATWQVVQS IPLAVSGNGP
TYKEQVLENM YSARRSSGRS MASDDDFPMA LEEEIPPKVR VKLCLKSSHE YCGDYMDAEI
GPALIHDSAF IATPTLIAIV VSCVVFALFV GLMLMFCRCK RNQTKKSNQT KDYEMDSVRP
SIVAQQSQAP PPYYPTTTGL DNKALEHSMD LALQLEDQKT SVYATHNGYG YHTGTGIQVA
GHSLPANEWV TMGYTENSYT NSNNGGSVNS QDSIWQMKGA PPPSTAGHHP ATMAAIGIQP
LSMGSLQHGG SAYATTTTTT TAAAAAAGSS TPGLAYGYDP IATHSNVYGG AMTIGGDEYS
QYPHQAATPS QHGGEDDYLH HHHHHAVAAM RQSQNPSRQQ EYCGDSYASV HKAKKRLDQP
SHFDSSYHDV SGLPDPYLDQ QQQQQQQQQP QHQLHQLDQE DSKSLLQLNH PQDHGSLHLH
AQQQQQQPQP IYEDNLESGY STPNSRNRRV IREIIV
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