ID A0A182UW36_ANOME Unreviewed; 1147 AA.
AC A0A182UW36;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2023, sequence version 3.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Moesin/ezrin/radixin homolog 1 {ECO:0008006|Google:ProtNLM};
OS Anopheles merus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30066 {ECO:0000313|EnsemblMetazoa:AMEM004653-PA, ECO:0000313|Proteomes:UP000075903};
RN [1] {ECO:0000313|Proteomes:UP000075903}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MAF {ECO:0000313|Proteomes:UP000075903};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles merus MAF (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEM004653-PA}
RP IDENTIFICATION.
RC STRAIN=MAF {ECO:0000313|EnsemblMetazoa:AMEM004653-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, adherens junction
CC {ECO:0000256|ARBA:ARBA00004536}. Cell projection, rhabdomere
CC {ECO:0000256|ARBA:ARBA00043944}.
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DR AlphaFoldDB; A0A182UW36; -.
DR STRING; 30066.A0A182UW36; -.
DR EnsemblMetazoa; AMEM004653-RA; AMEM004653-PA; AMEM004653.
DR VEuPathDB; VectorBase:AMEM004653; -.
DR VEuPathDB; VectorBase:AMEM21_008494; -.
DR Proteomes; UP000075903; Unassembled WGS sequence.
DR GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:UniProt.
DR GO; GO:0030182; P:neuron differentiation; IEA:UniProt.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd17098; FERM_F1_FARP1_like; 1.
DR CDD; cd13235; PH2_FARP1-like; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF5; MOESIN_EZRIN_RADIXIN HOMOLOG 1; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658}.
FT DOMAIN 50..335
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 651..835
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 864..955
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1026..1123
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 378..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 421..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 473..536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 554..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 608..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1128..1147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..526
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..571
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1147 AA; 130282 MW; 04FF1E5B84A3B961 CRC64;
MSLDSMGPSA GGGSSGVGTL SGTRMIHSLS TPSGVDGTVS TSHSRGGKKL AVRIQMLDDS
VTMFQVQAKA TGKVLFEQVC RQLNLLEADY FGLEYQEAPS GTKYWLDLEK SLNRQVGLSL
VEPVLRFCVK FYTPDPLQLE EEYTRYLFCL QVKRDLATGS LQCNDNTAAL MASYIVQASC
GDYAAEDYPD HTYLSSYRFV PQQDHTMQRR IMENHKKHVG QSPAEADLNL LETARRCELY
GMKMHPAKDH DGVPLNLAVA HMGIAVFQGI TRINTFSWAK IRKISFKRKR FLIKLHPENY
VYHKDTVEFF FEGRNECKNF WKKCVENHGF FRCTAVQNVQ RRKARVLSRG SSFRYSGKTQ
KQIIEFVRDN YVKRQTFQRS QSFRQGPLHS SNRSQSRTSC NVNQSISAHP LLPIETAEWE
RRSQSNVLRT PSQTRRQADM EVDRLPSSPT GHSRSQLTEA QVETYPMKSY TQQMGMEGSG
HTPLQDSSQS ASPGGTWSSP YHNSNSSSHA READRARARQ DGHSSDDYHG INGNVSLDRR
SEIVQSPNRY ELALGTADKS NNNSLSRGET GSYDLGSAEA RARNNNGHFG GSNGGALHTV
DENMINNNYQ NQQPSATNGQ TSSGVGLGNG NSGTLRSIDE EMRKKKWPTD RAYFLAKELL
MTERTYKKDL DVINTWFREE LTPEDLENLQ PLFQYFESML EHHSVFLRDL EHRILLWEGR
GGHETHRIGD VMLKNMVVLP IYDEYVESHR EILERLNDLY DNDDKFQQTY REFELQKVCY
LPISYFILKP LHRLLHYELL LELLLAHYGE DHFDRTDCHG TLMMLTRSTE VIRRELTASE
NHSLLCEIQR DIDGYDGLVQ PDRKLIRQGC LLKHSKRGLQ QRMFFLFSDV LLYAVKSPVT
QTFKVLGHVP VRSLLTENAE HNAFVIFGGQ RAITVSAGTT VEKTLWLEEL AKAANSLKYK
PQTQLPIVSI KTCTSSEENL EACGLSSALV PPAAARQPSP RNNTALHVCW HRGVTICLDD
HLRSGRNQIS GYLLRKFKNS SGWQKLWVVL TSFCLYFYKS YSDDAALASL PLLGYTVGPP
GIQDAVQKEY VFKLSFKNHT YFFRAESEHT YNRWMEVLRS ATQIQESRSS PTINSNNLIN
NNGSNGN
//
