ID A0A182UXZ8_ANOME Unreviewed; 993 AA.
AC A0A182UXZ8;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=valine--tRNA ligase {ECO:0000256|ARBA:ARBA00013169};
DE EC=6.1.1.9 {ECO:0000256|ARBA:ARBA00013169};
DE AltName: Full=Valyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00029936};
OS Anopheles merus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30066 {ECO:0000313|EnsemblMetazoa:AMEM005591-PA, ECO:0000313|Proteomes:UP000075903};
RN [1] {ECO:0000313|Proteomes:UP000075903}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MAF {ECO:0000313|Proteomes:UP000075903};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles merus MAF (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEM005591-PA}
RP IDENTIFICATION.
RC STRAIN=MAF {ECO:0000313|EnsemblMetazoa:AMEM005591-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
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DR AlphaFoldDB; A0A182UXZ8; -.
DR STRING; 30066.A0A182UXZ8; -.
DR EnsemblMetazoa; AMEM005591-RA; AMEM005591-PA; AMEM005591.
DR VEuPathDB; VectorBase:AMEM005591; -.
DR VEuPathDB; VectorBase:AMEM21_012829; -.
DR OrthoDB; 5473263at2759; -.
DR Proteomes; UP000075903; Unassembled WGS sequence.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004832; F:valine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006438; P:valyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd07962; Anticodon_Ia_Val; 1.
DR CDD; cd00817; ValRS_core; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR Gene3D; 3.90.740.10; Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR033705; Anticodon_Ia_Val.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR InterPro; IPR002303; Valyl-tRNA_ligase.
DR NCBIfam; TIGR00422; valS; 1.
DR PANTHER; PTHR11946:SF117; VALINE--TRNA LIGASE; 1.
DR PANTHER; PTHR11946; VALYL-TRNA SYNTHETASES; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF00133; tRNA-synt_1; 1.
DR PRINTS; PR00986; TRNASYNTHVAL.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363035};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363035};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363035}.
FT DOMAIN 65..660
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 718..855
FT /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF08264"
FT COILED 936..991
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 993 AA; 112237 MW; 1AAB12907391B7ED CRC64;
MLRVFRRNVG PPLWPGGCGR TAPSVILRQY GTGKEIASAY KPSQVERSCE SGTTPQLPSA
FNLTRDNAPP FNVLLPPPNV TGELHLGHAL TGAIQDALVR QARLSGRRTT WIPGMDHAGI
ATQVVVEKRL LKERNLTRHD LGRERFLQEV MRWKVEKQDS IRRALKKLGC SMDWSREYFT
MDAHQSVAVK EAFVQLFDRG LIYRDRSLIN WSCTLESAIS DVEVENVEIS GPTEIAVPGY
SRNVTFGRMV DIAYKVQGST EEIVVSTTRP ETFLGDVAVA VHPDDGRYSH LRNKVTFLWH
PVRKEEIPLI FDGAVDRSFG TGAVKITPAH DRFDFELGRR HHLATVEVID ERGRVQEHFG
PFTGMPRYEA REALLEYLAK LSLLRGIKPH TMLLPLCSRS KDVVELLLRP QWFVRCREMA
QRAMDAVREG KLEIVPNTFE REWFRWLDNC RDWCISRQLW WGHRIPAYCV RYDGAKERWI
AARSEEEARE KFTALEPNAA KDLVSIEQDP DVLDTWFSSG LLPFSSTGWP GTVSPAHYPL
QLMETGHDIL FFWVARMVML GQELTGKLPF ERVLLHGIIC DEFGRKMSKS LGNVIKPDHV
IHGISLERLQ AEAEDSHRQG VLSQAELGKS LAGQRKMFPS GIPECGIDAL RFTLCSANVK
NHFIHFNAQE AHTNKLFFNK IWQATRYTLA CAGRFNAGKT VDQTVDLRQA VDRMPLMDRW
ILSRLGNTVQ QCQEAFASYN FHLATAALKT FFYCNFCDVY LETTKINMKP ESTSVAALHC
AVLKYCLTVG LRQMEPFTPY LAQELLTHLC AASSSIPVDL DHDAALGWVD PPLEESIEGV
LQICQHIRQS KNEYNPPIVR KHNPILHIYA KAPKLAAELH VLRDTIQQLT HCNGVVLHSD
ERLFGNVQYV VKGAPTHDCL IGIVAESGGG GNGAGAEASR KMLAKLDAEI EKLLKTIGNE
GYKRSASESV QKRHQEKLDR LQQQREEMLK MAS
//
