ID A0A182V1P6_ANOME Unreviewed; 1108 AA.
AC A0A182V1P6;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
OS Anopheles merus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30066 {ECO:0000313|EnsemblMetazoa:AMEM007386-PA, ECO:0000313|Proteomes:UP000075903};
RN [1] {ECO:0000313|Proteomes:UP000075903}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MAF {ECO:0000313|Proteomes:UP000075903};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles merus MAF (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEM007386-PA}
RP IDENTIFICATION.
RC STRAIN=MAF {ECO:0000313|EnsemblMetazoa:AMEM007386-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A182V1P6; -.
DR STRING; 30066.A0A182V1P6; -.
DR EnsemblMetazoa; AMEM007386-RA; AMEM007386-PA; AMEM007386.
DR VEuPathDB; VectorBase:AMEM007386; -.
DR VEuPathDB; VectorBase:AMEM21_005942; -.
DR Proteomes; UP000075903; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR CDD; cd15047; 7tmC_GABA-B-like; 1.
DR CDD; cd06366; PBP1_GABAb_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF46; METABOTROPIC GABA-B RECEPTOR SUBTYPE 3, ISOFORM A; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR PRINTS; PR01177; GABAB1RECPTR.
DR PRINTS; PR01176; GABABRECEPTR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..1108
FT /note="G-protein coupled receptors family 3 profile domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008139103"
FT TRANSMEM 505..525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 546..564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 584..606
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 627..648
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 686..706
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 726..744
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 750..771
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 577..782
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 843..864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 930..949
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1108 AA; 123519 MW; 84169C2D953A4B0B CRC64;
MRRTTAGSSG YVPVVLMVLL LLLLVLFDTL LASESAANRK SSVQTNEHNR NIINTVFERT
RPAGSERRAR EVTILGLFEL SSREGAARRE GLSELAAAQL AVQHINRRGL LLGYKLKLIT
NDTKCDPGVG VDRFFHALYT HQSKRIIMVL GSACSEVTES LAKIVPYWNI LQVSFGSTSP
ALSDRREFPL FYRTVAPDSS HHPARIAFLM HFGWDTVATF SQNEEGYSLA VNDLVTELER
ANITCAATIS FAETDFKEQL KLLRDRDVRV IIGSFSHEIA PQVFCEVYNL GMYGAEYAWI
LQDTYISSWW LAGDLPETGS APCTSRALLT AVENLIIVSS YNSIVGMGTA LSGLTNDIFL
QKLREMNVTG AVSQFAPQTY DAVWAMALAL RGAERSWSQS VPHRVRLADY DYTRYDIAQE
LLRQFDLLKF NGISGPVSFE GADRIGTTSF HQIRAGQLEM IAFYYPKNAT LDFGCRYCVP
IVWPGGQVPI AKRILRLRVD TIDPFAFYTV VILSLIGIGI SVLFLGLNLR FRKLKAIKLS
SPKLSTITVC GCMLVYTATI LLGLDHSTLP WSSVTFSTIC MARIYFLSAG FSLAFGSMFA
KTFRVYRIFT HSAGGLCRDK ILRDTQLISV IGALLLVDAF VVSFWMAADP MERHLHNLSL
EISTTDRSVV YLPQVELCRS RHYESWLGML YAYKGLLLLV GVYMAWQTRN VKISALNDSQ
YIGISVYSVV ITSASVVVLA NLLYERVTLA FIITAGFVLI STTATLCLLF LPKIKDIFEK
GEVYDPIIHS MGLKMEFNTR RFVLDDRREL QFRVEVQNRV YRKELELLDA EICRLERALQ
ERSPQSSPLS SEPNLPDSRP CAIARPHGSS GLPMLLLSVL PPIIPRASWP SVDPMLSPMK
RNIAFSSQPK IDPAVTLAPT GSRERILTSN SRVRSDEPHT LPNGASSGVM GKIRHMFAPR
LHKAPSATML GGTGSSTSAI RKSALAIFNE IDTEDDLPQS IYTIDKPTRE QLTLTGSEPR
VNFVLPPNGR RRSSTVQQQG PVRDRIRGSP RFPHRICPQT TSLTELGIER PRISFLTVKS
CEQIHGKPCE SRAKWKSMDS FSKSVGSQ
//
