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Database: UniProt
Entry: A0A182V2S9_ANOME
LinkDB: A0A182V2S9_ANOME
Original site: A0A182V2S9_ANOME 
ID   A0A182V2S9_ANOME        Unreviewed;      1141 AA.
AC   A0A182V2S9;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   03-JUL-2019, entry version 19.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
OS   Anopheles merus (Mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=30066 {ECO:0000313|Proteomes:UP000075903, ECO:0000313|VectorBase:AMEM007907-PA};
RN   [1] {ECO:0000313|Proteomes:UP000075903, ECO:0000313|VectorBase:AMEM007907-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MAF {ECO:0000313|Proteomes:UP000075903,
RC   ECO:0000313|VectorBase:AMEM007907-PA};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA   Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B.,
RA   Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C.,
RA   Murphy C., Pearson M., Poon T.W., Priest M., Roberts A., Saif S.,
RA   Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Anopheles merus MAF (V2).";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|VectorBase:AMEM007907-PA}
RP   IDENTIFICATION.
RC   STRAIN=MAF {ECO:0000313|VectorBase:AMEM007907-PA};
RG   VectorBase;
RL   Submitted (JUN-2016) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
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DR   VectorBase; AMEM007907-RA; AMEM007907-PA; AMEM007907.
DR   Proteomes; UP000075903; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000075903};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000075903};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      164    514       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      579   1008       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     1046   1119       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION       54     77       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A182V2S9}.
SQ   SEQUENCE   1141 AA;  128859 MW;  A1B7FE18C2126AE2 CRC64;
     LYHCRPEAVG LFVVSIFIEP SRLLLKFLER CDSQVGVLPH TVYVPAVEMN TKRKPFTKPN
     EAASSSGPKK FRGGDDEEEE FESYFEAELA NLDDDADTAR IGLGPESENT CAKWSRPAPA
     PLDPAKDALV FQQIDIDNYI GQPMAGMPGA QVGPVPVMRM FGVTMEGNSV CAHVHGFLPY
     LYVAAPRGFS KAHLQEFRAA LDKAVLHDMR TNKDNVQEAV LEVELVERQS IMGYNGEDLF
     TFIRVTVALP KLLAAVKRLL EREQLMPSMD FQDCRVYESN IDFDIRFMVD TGVVGCSWIE
     LPAGSWTARR KGVQPGPETR CQLEVDVAFN AFVAHDPEGE WAKVAPFRIL SFDIECAGRK
     GIFPEPQHDP VIQIANMVIR QGEQEPFLRN VFTLNTCAPI VGAQVLSHKT EQELLDRWAC
     FVRELDPDIL TGYNINNFDV PYLLNRANHL KVRNFEYLGR VTNIRSVIKD TVIQSKQMGR
     RENKFVNFEG RVPFDLLFVL LRDYKLRSYT LNAVSYHFLQ EQKEDVHHSI ITDLQHESEQ
     TRRRLAMYCL KDAYLPLRLL NKLMCIVNYM EMARVTGVPL ACLLTRGQQI KVMSQLLRKS
     RVAGYLIPSY QSSGSEEQYE GATVIEPKRG YYANPISTLD FASLYPSIMM AHNLCYTTLV
     QPNMKDKLGL SPDQLTHTPA NNVFVKASVR KGILPEILES LLAARKRAKA DLKVETDPFK
     RSVLDGRQLA LKISANSVYG FTGAQVGKLP CLEISGSVTA YGRTMIEQTK QEVEQRYTVE
     HGYENDAVVI YGDTDSVMVN FGVKTLERSM ELGKEAADYV SAKFVKPIKL EFEKVYYPYL
     LINKKRYAGL YFTRPDRYDK MDCKGIETVR RDNSPLVANL MNSCLQKLLI ERNPDGAIEY
     AKQTIADLLC NRIDISQLVI TKELAKSDYA AKQAHVELAN KMKKRDPGNA PKLGDRVPYV
     LIAAAKNTPA YMKAEDPIYV LENCVPIDAN YYLENQLSKP LLRIFEPILG EKAESILLRG
     DHTRTRAVVT SKVGALAAFT KKRDACLGCK ALLAVGQEGK ALCPHCTPNE ASLYQGELAA
     QRTLEERFCR LWTECQRCQG SLHEEVICTS RDCPIFYMRT KIKMELETQE KRVARFGVPA
     W
//
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