ID   A0A182V5Y9_ANOME        Unreviewed;       805 AA.
AC   A0A182V5Y9;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=Glycoside hydrolase family 65 central catalytic domain-containing protein {ECO:0000259|Pfam:PF03632};
OS   Anopheles merus (Mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=30066 {ECO:0000313|EnsemblMetazoa:AMEM009410-PA, ECO:0000313|Proteomes:UP000075903};
RN   [1] {ECO:0000313|Proteomes:UP000075903}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MAF {ECO:0000313|Proteomes:UP000075903};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles merus MAF (V2).";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AMEM009410-PA}
RP   IDENTIFICATION.
RC   STRAIN=MAF {ECO:0000313|EnsemblMetazoa:AMEM009410-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 65 family.
CC       {ECO:0000256|ARBA:ARBA00006768}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A182V5Y9; -.
DR   STRING; 30066.A0A182V5Y9; -.
DR   EnsemblMetazoa; AMEM009410-RA; AMEM009410-PA; AMEM009410.
DR   VEuPathDB; VectorBase:AMEM009410; -.
DR   VEuPathDB; VectorBase:AMEM21_001150; -.
DR   Proteomes; UP000075903; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 1.50.10.10; -; 1.
DR   Gene3D; 2.60.420.10; Maltose phosphorylase, domain 3; 1.
DR   InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR   InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR   InterPro; IPR005195; Glyco_hydro_65_M.
DR   PANTHER; PTHR11051; GLYCOSYL HYDROLASE-RELATED; 1.
DR   PANTHER; PTHR11051:SF8; PROTEIN-GLUCOSYLGALACTOSYLHYDROXYLYSINE GLUCOSIDASE; 1.
DR   Pfam; PF03632; Glyco_hydro_65m; 1.
DR   SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..805
FT                   /note="Glycoside hydrolase family 65 central catalytic
FT                   domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5008139297"
FT   TRANSMEM        755..775
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          314..521
FT                   /note="Glycoside hydrolase family 65 central catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF03632"
FT   REGION          780..805
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        780..796
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   805 AA;  91188 MW;  E9DBF2DA5B70F446 CRC64;
     MWLLTLFTVA LGVSAVCAND YNFLFNATKL PNKAVTPTLA NGHLGFVVYG YSVHLNGVYN
     GLKGVSHRAR IPNYANIQLA NCSSLQTQPR NCHYQLDMRS GKFRTTLEDP AGGYRVQHEV
     YPNRHFDQTI VNRIHLRRLS SKQTIEIETR QLIGGKSVDL VEEPLEKLTV AGEEFLLLCA
     KTRQVEDPKY QREGHTVCVA YKQVPRKLTL TAEETDREFL FLTVFSHTRQ ELEQELRGLK
     ANDHERLHRL EMDRMWAKYG IRVEGNDRLD RVIKASAFYL SSSLPSQTSF QPSSYPFYGL
     SPSGLGRGGK KLAEYQGHSF WDTEMWMFPP VLLLDPQNAR KLLHYRTLVT EAAADYARRN
     GYEGWQYAWE SAYTGREVTP DHCPQVPEYQ HHITGDIAYA VRLYYYATGD LDWLRSDVCR
     LVYETARFWK SRVDYNADTD TFDIGRIMGP DEDHHNVTNS IYTNVIAAHN LFFGAFVGCH
     CRESLPGVTE DEFAQFLRVA KSITLPYNAQ YDVHPEYKEY TFGTQIKQAD VVLLGYPLEF
     PMKQSTKANN LRLYSMVTRP DGPAMTWAIH TIGHLDLNEL DHAAAMFRKS YKQYLRAPFH
     VWSENGDGAD GAGNFITGAG GFLQSLINGY AGVRLRHGKL VIDNPRLPPA TTRLFIPELN
     FAGVKFALDI GQSGFRITFG AAAGESFEKL TLLVDDLERE LFEGCEYAGS NNAELRLRND
     QNVTDGEHSS CTLHDTVLGM RLADQDGRLL STTQLIVLSL TVGLLGVLYS IRAAFRNKRG
     RGKVSTDKEN MSKRLQKKQK NKSAK
//