ID A0A182VA69_ANOME Unreviewed; 1224 AA.
AC A0A182VA69;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Invasion-inducing protein {ECO:0008006|Google:ProtNLM};
OS Anopheles merus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30066 {ECO:0000313|EnsemblMetazoa:AMEM011479-PA, ECO:0000313|Proteomes:UP000075903};
RN [1] {ECO:0000313|Proteomes:UP000075903}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MAF {ECO:0000313|Proteomes:UP000075903};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles merus MAF (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEM011479-PA}
RP IDENTIFICATION.
RC STRAIN=MAF {ECO:0000313|EnsemblMetazoa:AMEM011479-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR AlphaFoldDB; A0A182VA69; -.
DR STRING; 30066.A0A182VA69; -.
DR EnsemblMetazoa; AMEM011479-RA; AMEM011479-PA; AMEM011479.
DR VEuPathDB; VectorBase:AMEM011479; -.
DR VEuPathDB; VectorBase:AMEM21_012953; -.
DR Proteomes; UP000075903; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd01224; PH_Collybistin_ASEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00174; SH3; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45834:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 3, ISOFORM L; 1.
DR PANTHER; PTHR45834; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9-RELATED; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 464..539
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 621..819
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 132..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 412..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 553..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1036..1077
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1105..1191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1105..1175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1224 AA; 133140 MW; 05336ECA17537EFD CRC64;
METTYRKRQR CRVKMLLKNR QSYSITRLRP ASAVGHHSSY HSHHQKDKLR LGYSVLRAYS
SYLGYGDIGS LYHRRGVPAS PAIGQEYYTP LLPEDDDFPM ADDSGWACDP TPLQLRAVSS
PSISEAPIEV VAPAGRSRKD AESPNHLSTA GANAHLNPPT TNVHQHPSST IVSSSAPHQK
TVQTKVSTAA THHPVQVSES VLQKFRKTFS HFKTSKSAPH PVTAAGVTTP TTTAGLTTST
DLQTAGATMS VDDKQQQPQQ HHHHRFGPLI WRSSKERRKT KSHRRDKCNS GDSGIQVELD
NDADQHLLLQ QLHPLEHHHP AGVDAGRNGD APPQYTATGG VPVRRANSAK VSTASSTGST
SSTTLLKHKL SLKGKGKENV SNITRLSGKS LSQPSGLDCI VASGGDSADC GAGVDGMRRR
RRQHTRTSTT IPTELDLSDS ESISSHPDED DEAVAVEDEL LVAAEPVFAE VLFSFRPGGP
QELALEKGAL VEVLKREQGP WWWGRLKSDA IVSEGGDCSK PSNGACGWFP KDFVKIVPTY
AKPKQIIIIS SQGEPNKQHH PAGEDDDGAS SSASTLIEGG GHCDSTRLMG GLSMAGDATA
APVEGAGQGE EGAGATSHDL TKENIIKELL ETEINYVKLL NSLCLGFIKP LREREDVFSV
ESVNLIFSNL EKIWRFQQTF LDALRVAVPN NRIGEVFLEY QSAFMVYSSY CNSYPRALME
LENYANNKEA NQILENCRMA ENLPELPLSA HLLAPIQRIC RYPLHLSELV KHSLTRKELL
PTLNLRKCTK SELETMDCRE VFELALSAMR RVTEMVNEGK RHSEYLSRIQ ARFENFQGPS
INVHSTRLFL QTDAIRMSPN LWNNTYTLFL FDRQLVYCKK DLLKRTNYIY KGRIFLDNCR
ILNLPDGKMF GVTLKNALRL YCDTRNKWFD FCFRSSSSKL RFLNTLSSER QFCGESLFVS
ELDGGAASCF DDDNLSDREY FPYVDVDSKE SMVGENGADS NLYDVVDAGS FRPSVASSVS
SSLSVSSQQY AKESLSARAS ATGAPPMMPP AAPLSGSAGG GNTLPKKSRK MPKEAVLQQQ
QVLASGEYGS NSLGRRKLGN WFRKAKSTNS TPSQSPTHHP MAMSLASIGN SSNHNNHSDS
SSQSSLASGF QQQRALSTLG TGSTALTSSG TALSTGPGGK GKPSKPDTVA PVAVVESSQS
QSITLTNATA ATSTAAAAAA AASS
//
