ID A0A182VAK5_ANOME Unreviewed; 3614 AA.
AC A0A182VAK5;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Histone-lysine N-methyltransferase {ECO:0000313|EnsemblMetazoa:AMEM011678-PA};
OS Anopheles merus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30066 {ECO:0000313|EnsemblMetazoa:AMEM011678-PA, ECO:0000313|Proteomes:UP000075903};
RN [1] {ECO:0000313|Proteomes:UP000075903}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MAF {ECO:0000313|Proteomes:UP000075903};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles merus MAF (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEM011678-PA}
RP IDENTIFICATION.
RC STRAIN=MAF {ECO:0000313|EnsemblMetazoa:AMEM011678-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR STRING; 30066.A0A182VAK5; -.
DR EnsemblMetazoa; AMEM011678-RA; AMEM011678-PA; AMEM011678.
DR VEuPathDB; VectorBase:AMEM011678; -.
DR VEuPathDB; VectorBase:AMEM21_009193; -.
DR Proteomes; UP000075903; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProt.
DR CDD; cd04717; BAH_polybromo; 1.
DR CDD; cd05525; Bromo_ASH1; 1.
DR CDD; cd15548; PHD_ASH1L; 1.
DR CDD; cd19174; SET_ASH1L; 1.
DR Gene3D; 2.30.30.490; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR017956; AT_hook_DNA-bd_motif.
DR InterPro; IPR006560; AWS_dom.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR043320; Bromo_ASH1L.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR043319; PHD_ASH1L.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46147; HISTONE-LYSINE N-METHYLTRANSFERASE ASH1; 1.
DR PANTHER; PTHR46147:SF3; HISTONE-LYSINE N-METHYLTRANSFERASE ASH1; 1.
DR Pfam; PF17907; AWS; 1.
DR Pfam; PF01426; BAH; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF20826; PHD_5; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00384; AT_hook; 6.
DR SMART; SM00570; AWS; 1.
DR SMART; SM00439; BAH; 1.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51215; AWS; 1.
DR PROSITE; PS51038; BAH; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 2711..2757
FT /note="AWS"
FT /evidence="ECO:0000259|PROSITE:PS51215"
FT DOMAIN 2760..2876
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 2884..2900
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT DOMAIN 3120..3186
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 3344..3463
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT REGION 1..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 761..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 795..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 897..1008
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1024..1223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1414..1467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1496..1878
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1915..1937
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1993..2078
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2109..2213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2231..2273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2287..2331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2363..2591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2629..2652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2906..2991
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3028..3065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3505..3558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..393
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..642
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..748
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 905..923
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 947..962
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 987..1003
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1024..1069
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1078..1092
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1121..1141
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1153..1170
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1426..1440
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1514..1534
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1592..1613
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1616..1710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1734..1764
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1784..1873
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1923..1937
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1993..2009
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2010..2026
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2047..2065
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2189..2208
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2287..2306
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2381..2400
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2414..2430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2470..2484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2492..2519
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3049..3065
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3614 AA; 377424 MW; BB4BC5D0BE5EA71E CRC64;
MTIVKSSTAD AAGTNPADNA KSPLSSSSSS SSSSDSDDGS DSSSDSDSSS ASTSKTSSKQ
SSGGGGGVPP EKPQQFSVMS SDSAGLRMKI AIPRSQSNAT PTPSPTASIG SNHQHQQLMQ
QDSLPVGGGA AAAAADRRQK NAENVLGGER ASPAGLVLPA GSSTKVDSFK DGATKKGSNA
AKSAMVTAVE TSSTRARAPP PPTAQQRVSS EGGGSKALTA TAASRKQGSR MLPDDKREER
SRAMHTKARK RRSSSGNDGS SAGRTKKSVS ESDSSSASSS FSSCTSNSDS DTSSTAGDNS
NHHQQQDDKA KQTVGGGRHA RTASSAAVAS GSAIAAGKKQ KILKRKKASR TATSSSSDEE
DEEDLPSGRS GSKSGAANRT NEFTSSDSSS SDEDGKAFAA MRTKAKSLQS TKGSGKDGNG
LLTLTDGSAG GLLLNRPPLS TSTPAKQHGA FPPTLGGGMS SAGDGGLTAE GGSCSSDNEL
PALVSAAIRR VESGSDAESI RGLSAPTQQY TSSLLRDFVV KTQMLGTVGG SGAGAMPAGV
SGTAVNSAAG GGGGGSPSSS SSSSSSSGSS SSSSSSSMEE GADPAIGSAG PGPGGGGGGG
GVAAFELDIR KIKTESPVPS TLPPASVGRN TPLVNGLTTG GMKTTDLPVP APAPKRRGRP
PKSSLQAAPA PPPAARPTGS SRSVTIPTVS ESPDSGILST HSSTGSPKTD KTRSASHLRS
TVGATSSSTS SRRSKSEARG SASSASSAIL SAGGAAYAAN SVLPVPPGAA GSGSRTSGAA
SSYALTSCLD RNTYATERVL YPPRGPKKRG VGRPPKKDTA AHQQPAGAGR GGPANDPAAR
SQQQAEDRLD PHWQKIDISK KFHEPRLSGY KSDGGHSTIC CSKRLASQSG YISDYGGVGA
SSGRSRLSGY KSDFSSRSRR SCSRAGGYRS DYGRAKSCGY RSDCSTRHRK QVRRKRRKKI
GSHQQQQQQQ QQHHNQHDHQ HHNNNLSDRK NYNASSDGGG GGGSTKSASV GELEIMFMAG
LTLGSTSDED SSSTSSSTSS SSAESRESLF TDHSGVDRGA NSSSGADKVK RATSGRGRKA
NVATTKSNAK LPRTPRKPTP PKTVAKGRGA AKAPRGRPPS STTIDRRRKA NLAKHGSNKL
DSDDEDEDEE EEAELVVKRR FGDRVRTKPL QPAPKDPPTK PSVAATASVA LKQKSSALVK
RGRPPGVKKQ PGGTGSTATA GALPAGKSVG SLDVLLAPKN STAPVLPVNN FDRVVASMSG
SSKQQPGSSE AKKSSIYTFS STTVAPKNAF AAFLLRGAAA DDGGKDDAEE GGRLLGVKKL
PLSKANVIKN SEECSRRFQK STSSFALGGI AGSVDLLARI ADGTIPKASP TKSVCSKRSR
RKSCASDRLE VMSVKSYGVI GSCGKIRQRR LSTMSRCSSR SAGSRHAAAR MRRRKKRLRS
MSVAPGTTAE MVSGGGGGGA ASGAASSSGL DLKLNVEIDR LSESFSGMCR IVGGTVSNEA
GQAPSGAGRS VSPPEEATAT NAPAAATPTS GKGHQTKRSV KKRKASEHVT DSPSTTGGAN
APGGGGGGAA ALGNGGGAGG GGGTGKRRNK KTVPTQSPDD HKLPLKKRHY LLTPGEKGNN
SDNNSGVDEV KTGSSGGNGG GVGGSSATAA GSNVDSGNSS TSGATGSGSG SANSSFTGSH
TVLNPCAFAS GARSSANSAA TGSSISGAAT KAVTPKKRHL LKSPEPGPVP TDTELQLQIK
SSDSPLTIVN GGGASGTVGD AGSSLSDGHT AGRKAAVDGA VGGSPSNATG QANPSATGGG
SKKKTNRQQE GSSISSSTVS RERQTTGASG QPGTMSESSA GPQHRSTPPA RPSVIQSSGS
VHPAASSGAY SASSAGPPPG VFEPTVDLEL VIPPPSSIPS LIAKVEMLDS PRLGGKDAAA
AGAIGSSSSS GSSGNVATKL ESEELQVLTA AQRKAAGLGA GSALLATIST ASASSEKVLE
KLLTKTGAHH LLMKKKRKKP NRTGFPTVKK KKKKLPENDP LDDGLSVLDL KPEVGPDLFD
SSNLTRHVPS EAEKTRMKER QQQQHPSTGK HAACDRVPKE GEPTDCFIER HTGVGRPRLS
VVSLEKLQGK LPLPGGGSRD VATTPPATGG RGRKSVINPL AAEHQLAAHR SRGLRDEPPA
AAAGTVGRKG KKRQEAPKPL PETAVGKRQK ASMDTEIRSA KERNRSKSVS VASEQLPNIV
RLSETLSKVA AAKENKENSR LPPGRPPSAA KRAGKEPATS AETSPQDDAA GVIRRTRSSS
VALDPSEVKK LHHHYHQQHD AEHESAGKGA SQSSTPVRPH SGGIAALHNE DSTSLDSMPL
LKRLHSRSIS RMQSVITPTV VIEPIATSPK TPGRPRGRPR TTSPITATET PNSPTATTGP
GRGRPRTALA LTGNPSAAFM QRTPASPLSS PSPMVAAAER TAGRKKQRLD GRKSVPPGLA
EPIESARLAT RVTASKSVTP TPPVGTVIPT RLKRGKSDET LRAQQLEKPN KKPRKELPGS
GEPSPETAAH LSKRSAIASP IVEPVDPEET AHVLQPASST EELEHDPLPP DEGPSDFLRL
TDTPSPMSSG EARELAMGGA AAGGRGAGTS KKLPRKKYIT AGLFSDCYKD DGTTGGEGRS
GPKTPPETLL PPPAYCERFL RRTVRDFQLP YDLWWLQENG KLPGRNSVPS WNYRKIRTNV
YYDVKANPST DNNTQCNCKP DSGCQDDCLN RMVYTECVPE QCPCGDRCRN TCIQRHEYAP
GLERFMTEEK GWGIRSRERI SKGTFIMEYL GEVVTEREFK ERMRTMYLND THHYCLNLDG
GLVIDGHRMG SDCRFVNHSC APNCEMQKWS VNGLFRMALF AMRDIPPNEE LCYDYNFSLF
NPSEGQPCRC GSEQCRGVIG GKSQRIKPIP LGSSGGSAGG PGGIGGQRNA SEAGADTDAS
KAAGADGTAG GNGASGALVV ELSPRSAARS RKRQAKKNQP IVHLNGTPLP TFHPPSVKER
ALIAEHHCFL LRNLNKIRRQ KERAATLASA AGGGSGGAGA AATESGGQGA AAGSDQTVGG
SGKPSLASQI SALRCPRNIR TRGLAFVEDD PELEKTARIA VALKDICTEI ATLKDDKGVP
FISKLQLPSK KKTPLYYERI PKPIDLAQIE TNIEQGVYRM PKVFEEDLLI MLSNAIKYYG
INSPEGIASE ALKSHYYTCK QQQVPKLQAY IGEENELLRG FVPKKEPAED AVPPKPKRGR
RQEQPEDIIR CICGLFKDEG LMIQCSKCLV WQHIECTKAD PAVENYLCEK CDPREVNYEI
PLNEFTEEGY QYYVSLMRGK LQIRQTDTVY VLRDIPMSPD PKNPNAPVRK HTYETIGKIE
YSECDIFRVE SLWKDKEGRR FVYGHHYLRP HETYHEPTRR FYPNEVMRVP LYEVIPIELV
VDRCWVLDPI TFCKGRPVDS SEPHVYICEL RVDKSARLFS KISRHSHPVC MKSYAFHKFE
QKLKIAKTFA PHDLGSLAHL LSIRDKQKKG SKKDDGSGGQ TSAGSAAGGS SGFGGAGGSH
SGGSKKMTPI IQLLPPPPKT LAEKRNRLEQ VLARLMQKLA LNPNALPVVD ISYLLTGRGA
RLRRTNNSTP VPII
//
