ID A0A182VBD0_ANOME Unreviewed; 1663 AA.
AC A0A182VBD0;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=ABC transporter domain-containing protein {ECO:0000259|PROSITE:PS50893};
OS Anopheles merus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30066 {ECO:0000313|EnsemblMetazoa:AMEM012073-PA, ECO:0000313|Proteomes:UP000075903};
RN [1] {ECO:0000313|Proteomes:UP000075903}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MAF {ECO:0000313|Proteomes:UP000075903};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles merus MAF (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEM012073-PA}
RP IDENTIFICATION.
RC STRAIN=MAF {ECO:0000313|EnsemblMetazoa:AMEM012073-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR STRING; 30066.A0A182VBD0; -.
DR EnsemblMetazoa; AMEM012073-RA; AMEM012073-PA; AMEM012073.
DR VEuPathDB; VectorBase:AMEM012073; -.
DR VEuPathDB; VectorBase:AMEM21_004195; -.
DR OrthoDB; 773084at2759; -.
DR Proteomes; UP000075903; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229:SF250; ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 3; 1.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 331..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 365..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 438..461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 895..916
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1066..1086
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1107..1132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1144..1167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1179..1199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1279..1301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 520..750
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1345..1575
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 488..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1663 AA; 187060 MW; 62F67B372BE0DB36 CRC64;
MSTSNWGKFV LLLWKNWIIT KRHYLQTFFE IAIPVLACIL LIVIRGLVDA EEFEQPTIFN
PLELNTISHL RNNSQIDPPI IYSIAYSPQS PLLQSIVERS TAYLDEELAV IAFNSSQTLQ
AHLQVNNILV GIEFPDIYAN LTQLPEQTVL SLRYPSEMRT FRETGTEFWN NWQTERLFPP
FQVPGARQFE RDDGGYPANY YNETFLQIQS AISRSILQQR DPNYQFPDVY LSRYPYPPFY
SDNLLVGLEN LLPLIIVIAF FYTCINTVKY ITVEKERQLK EAMKIMGLSS WLHWSAWFVK
CISLLLISIS IITVLLCVSI TTNTELAIFT FANWFAIWFY LFIYSLATIT FCFMMSTFFS
KANTASGIAG LMWFVFVMPY NIAFSNYDTM SLSVKLALCL FHNSGMSFGF MLIMRHEGTT
NGLQWSNMFD PVTVDDDLSV GATMMMLLAD AVIYLVIALY VEKVFPGEYG VAEPWYFPVT
KKFWTSQVTP AGGEEGGEQQ HDTDGSTTVE AEPVGKYAGI RIKGLRKVFN KTKVAVKGLH
LSMFEDQITV LLGHNGAGKT TTMSMLTGVF SPTSGTALIN DCDIRTNIEG ARKSLGLCPQ
HNVLFNEMTV SEHIKFFARL KGVESKGIPQ EIDHYVSVLQ LEDKRHAQSH TLSGGMKRKL
AVGVALCGGS KVVFCDEPTS GMDPTARRAL WDLLIQEKKG RTILLSTHFM DEADILGDRI
AIMADGELKA AGSSFFLKKR FGVGYRLICV KEDGCDSTRV TDLMRKHIPN LDVDTDIGTE
LSYVLDDEYT ALFQPLLQDL ETHSTSLGIS SYGISLTTLE EVFLRVGSDS HALDKKPNGT
DQPAQPYALT ETWNGSTVTL TLDDQDQKLL TGFPLLSNQL QAMLLKKAIA TKRSWIALLV
QIFIPIFFVI MTVVIVRSFP DALSLPALPI GFDSYSSTVT VLEGTSADTS VIQAYQQLFE
GAGSSRSLVT VTEPMVDYIL KRYEQNLPQV NNEFMVGASI TPTNHTVWFN AQGFHTAPLA
VSTFYNAMLR TVCAQCSILI TNDPLPFRPE TRFTQLQAGN NMGFQLAFNT GFAMAFVAAL
YIMFYIKERV TRSKLLQFVS GANVLGFWLI SFLWDFMTFF VTIMFYVAVL AAFQEDGWST
GDEIGRVILV MVVFGFAFLP LTYLLSFAFD IPASGFVKVM ILNIFTGTIF FMTVFLLLFD
GFDLRHVAEG MEWAFLIFPL FALSHSLSNM NIAVATQQVC DSQCALIPNC TPELLCRVFP
QCCNTEIFTF ERTGISRNLM YMFVVGLISF LLLMCIEYRV IDRVFKRKSK QAAPPSESDE
IDSDVRMEKL RVRGLTEGEI AANNLVLRDV TKYYKKFLAV NQLSLAVEHS QCFGLLGVNG
AGKTTTFKMM TGDENISYGE AWVNGVSLNS NMNEVHRRIG YCPQFDALID DLTGRETLRI
FALLRGIPKS EIAALSSRLA EELNFAKHID KQTKAYSGGN KRKLSTALAL MGNPAVVYLD
EPTTGMDPGA RRQLWDVVCK ERAAGKAIVL TSHSMEECEA LCTRLAIMVN GEFKCLGSTQ
HLKNKFSNGY FLTIKLKRTE VVNTGRIDEV KQYIVERFPE AELKEEYLES VTYQIPSANT
RWSTMFGIME DAKKVLDIED YALGQTSLEQ VFLYFTKFQR VED
//
