ID   A0A182VCG7_ANOME        Unreviewed;       699 AA.
AC   A0A182VCG7;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=SH3 domain-containing protein {ECO:0000259|PROSITE:PS50002};
OS   Anopheles merus (Mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=30066 {ECO:0000313|EnsemblMetazoa:AMEM012610-PA, ECO:0000313|Proteomes:UP000075903};
RN   [1] {ECO:0000313|Proteomes:UP000075903}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MAF {ECO:0000313|Proteomes:UP000075903};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles merus MAF (V2).";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AMEM012610-PA}
RP   IDENTIFICATION.
RC   STRAIN=MAF {ECO:0000313|EnsemblMetazoa:AMEM012610-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   AlphaFoldDB; A0A182VCG7; -.
DR   STRING; 30066.A0A182VCG7; -.
DR   EnsemblMetazoa; AMEM012610-RA; AMEM012610-PA; AMEM012610.
DR   VEuPathDB; VectorBase:AMEM012610; -.
DR   VEuPathDB; VectorBase:AMEM21_002265; -.
DR   Proteomes; UP000075903; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0002039; F:p53 binding; IEA:InterPro.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR047163; ASPP1/2.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR24131:SF10; ANKYRIN-REPEAT, SH3-DOMAIN, AND PROLINE-RICH-REGION CONTAINING PROTEIN, ISOFORM B; 1.
DR   PANTHER; PTHR24131; APOPTOSIS-STIMULATING OF P53 PROTEIN; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   SMART; SM00248; ANK; 2.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 2.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   REPEAT          528..560
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          561..586
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   DOMAIN          627..690
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          104..123
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          236..265
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   699 AA;  76753 MW;  9136773939FB5BEC CRC64;
     MNDKPQQSIS NSSDYIQPQH VQQLQLQNYQ WEHENSVKTI ACEEAMLFAP ESDEKKLAVR
     QQQQHQQQQY QSCFAENLGN VSGTGTENGT ITGKEVHQNM LSDDFETKSN SNSPSNCDNS
     NDYESDLVVS LDKEQSNDSN TEIANSIGNS QDKLKHNNLS QPKASHIFLQ NIPLGNLVVS
     PRKPINSVAP TLALKPSSST VASAYNLCGT TGVKITRVTR KVPTCIESNV MTLSEADPTT
     ISTSPNNNNR PALPPKPNKI SGVSNAGTNP LVVAGNSNEM EEYGNEMNVA FIEGLTKNEI
     DASASASFDI PDLSLQGAIN KQSTVNDKLP IKAKPLTIRK HPFLEQPKLK NFTNSVNLNC
     NANTGLNKFP ISSATQQIIN KRKETVIPNT SEVNETINYS TCESESLHST KYVSDNSEFH
     AGREHPIERL KKLKSGNCNS TDGNLDNEVT RRKRNFILME PDVQGNAADI GTDNGNGITL
     GEGSKHKLSR RVSFDPLALL LDASLEGELE LVEKTAMQVT NPSAANDEGI TALHNAICAG
     HFEIVKFLVN FGCDVNAQDS DGWTPLHCAA SCNNLPMVKF LVESGACLFA ATLSDHETPA
     EKCEEDEEGF DGCSEYLYSI QEKLGILNNG EVYAVFSYES QQPDELSFFV NDTLTIIRKG
     DEAEREWWWA RSSLGSEGYV PRNLLGLHPR LTPSYNDEN
//