ID A0A182VD08_ANOME Unreviewed; 675 AA.
AC A0A182VD08;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=SPX domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Anopheles merus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30066 {ECO:0000313|EnsemblMetazoa:AMEM012877-PA, ECO:0000313|Proteomes:UP000075903};
RN [1] {ECO:0000313|EnsemblMetazoa:AMEM012877-PA, ECO:0000313|Proteomes:UP000075903}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MAF {ECO:0000313|EnsemblMetazoa:AMEM012877-PA,
RC ECO:0000313|Proteomes:UP000075903};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles merus MAF (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEM012877-PA}
RP IDENTIFICATION.
RC STRAIN=MAF {ECO:0000313|EnsemblMetazoa:AMEM012877-PA};
RG VectorBase;
RL Submitted (OCT-2016) to UniProtKB.
RN [3] {ECO:0000313|EnsemblMetazoa:AMEM012877-PA}
RP IDENTIFICATION.
RC STRAIN=MAF {ECO:0000313|EnsemblMetazoa:AMEM012877-PA};
RG EnsemblMetazoa;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SYG1 (TC 2.A.94) family.
CC {ECO:0000256|ARBA:ARBA00009665}.
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DR AlphaFoldDB; A0A182VD08; -.
DR STRING; 30066.A0A182VD08; -.
DR EnsemblMetazoa; AMEM012877-RA; AMEM012877-PA; AMEM012877.
DR VEuPathDB; VectorBase:AMEM012877; -.
DR VEuPathDB; VectorBase:AMEM21_012616; -.
DR OrthoDB; 7162at2759; -.
DR Proteomes; UP000075903; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd14477; SPX_XPR1_like; 1.
DR InterPro; IPR004342; EXS_C.
DR InterPro; IPR004331; SPX_dom.
DR PANTHER; PTHR10783:SF103; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1; 1.
DR PANTHER; PTHR10783; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED; 1.
DR Pfam; PF03124; EXS; 1.
DR Pfam; PF03105; SPX; 3.
DR PROSITE; PS51380; EXS; 1.
DR PROSITE; PS51382; SPX; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 461..479
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 491..510
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 539..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..167
FT /note="SPX"
FT /evidence="ECO:0000259|PROSITE:PS51382"
FT DOMAIN 420..624
FT /note="EXS"
FT /evidence="ECO:0000259|PROSITE:PS51380"
SQ SEQUENCE 675 AA; 78721 MW; D4C25C8D7B6AA35A CRC64;
MKFAEHLSAH ITPEWRKQYI NYEEMKAMLY TANEEAPALD SVEEDVRKRH FANFDENFYH
YCDQELKKIN TFYSEKLAEA TRKYAALNTQ LRTTLEGQQK SKSKGHSHKP INLPYRKAQE
LKLAFSEFYL SLILLQNYQN LNHTGFRKIL KKHDKILASD NGARYQKEHV EMSHFFINKD
IDKLINDTET TVTTQLEGGD RQRAMKRLRV PPLGEQQSPW TTFKVGLFSG SFVVLFVAVI
LSAVFHDSAT GENLKIAFRL YRGPLLLIEF IFLIGVNIYG WRSSGVNHVL IFELDPRNHL
SEQHLMEMAA IFGVVWTLSL LSFLYSTSLS IPPYINPLLM TVIMIAFLIN PLRVFRYEAR
FWLLKTIGRM IAAPFFHVGF ADFWLADQLN SLVTALLDFQ FLTCFYVTNG NWLEAGNTRQ
CMEESYILRP IVNCLPAWFR FAQCLRRYRD SREAFPHLVN AGKYATTFCV VIFATLRSAN
ASKYEDSSEN VFLWLWLISS VVSSCYAYTW DIKMDWGLFD KNAGENRFLR EEIVYSMPFF
YYFAIIEDLL LRFVWILSYA LTENKLISGD LMTSILAPLE VFRRFVWNFF RLENEHLNNC
GKFRAVRDIS IAPIDSNDQV IILKMMDEED GVINRYTKHN RPKPKKMKDD RRALLPAFKT
THEVIPPDAT NVKQA
//
