ID A0A182VE27_ANOME Unreviewed; 601 AA.
AC A0A182VE27;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Transforming growth factor beta-1-induced transcript 1 protein {ECO:0000256|ARBA:ARBA00044082};
DE AltName: Full=Hydrogen peroxide-inducible clone 5 protein {ECO:0000256|ARBA:ARBA00044270};
OS Anopheles merus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30066 {ECO:0000313|EnsemblMetazoa:AMEM013398-PA, ECO:0000313|Proteomes:UP000075903};
RN [1] {ECO:0000313|Proteomes:UP000075903}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MAF {ECO:0000313|Proteomes:UP000075903};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles merus MAF (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEM013398-PA}
RP IDENTIFICATION.
RC STRAIN=MAF {ECO:0000313|EnsemblMetazoa:AMEM013398-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Nucleus matrix
CC {ECO:0000256|ARBA:ARBA00004109}.
CC -!- SIMILARITY: Belongs to the paxillin family.
CC {ECO:0000256|ARBA:ARBA00005813}.
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DR AlphaFoldDB; A0A182VE27; -.
DR STRING; 30066.A0A182VE27; -.
DR EnsemblMetazoa; AMEM013398-RA; AMEM013398-PA; AMEM013398.
DR VEuPathDB; VectorBase:AMEM013398; -.
DR VEuPathDB; VectorBase:AMEM21_014701; -.
DR Proteomes; UP000075903; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd09336; LIM1_Paxillin_like; 1.
DR CDD; cd09337; LIM2_Paxillin_like; 1.
DR CDD; cd09338; LIM3_Paxillin_like; 1.
DR CDD; cd09411; LIM4_Paxillin; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 4.
DR InterPro; IPR001904; Paxillin_Lim_dom4.
DR InterPro; IPR047075; Paxillin_TGFB1I1_LIM_dom1.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24214; PDZ AND LIM DOMAIN PROTEIN ZASP; 1.
DR PANTHER; PTHR24214:SF38; PDZ AND LIM DOMAIN PROTEIN ZASP; 1.
DR Pfam; PF00412; LIM; 4.
DR SMART; SM00132; LIM; 4.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 5.
DR PROSITE; PS00478; LIM_DOMAIN_1; 3.
DR PROSITE; PS50023; LIM_DOMAIN_2; 4.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 366..425
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 426..483
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 484..543
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 544..601
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT REGION 80..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 302..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 601 AA; 66469 MW; 497EDC1006A89A5B CRC64;
LVATSSRCVC RATSVKWIKF LLTHQQTKRK GAVESNLFPV EAPNGALMRD PKMEQITYES
VQENCQDFLD ALLADLQNTV PGHNQQQHGG GGGGGGGGGS SVPGYGSLNG VRNKQQTSPV
PQTYQNTTAK TVTESRATNG YNGSLPRSTT PHNSLPRSST PQKLQTSASG NLSELDSLLQ
DLSSARYGNV AEKRKSTATR QTTIHLIKRP SVDSLLEELS NAHSNPIYAV PHGNQNANQP
GRQVTITVRE TTTEKLTGTP SAQYQNQLYQ QQLAQNESHT SSATKELDDL MASLSDFKIS
AGTSHQHQSV TDYAKPNQGT SHYQSTLTTV STTEHLPPAS SDQLDSMLGN LTADMSRQGV
NTTQKGCCNA CDKPIVGQVI TALGKTWHPE HFTCNHCNQE LGTRNFFERD GNPYCEPDYH
NLFSPRCAYC NGPILDKCVT ALEKTWHTEH FFCAQCGQQF GEDGFHERDG KPYCRNDYFD
MFAPKCNGCN RAIMENYISA LNSQWHPDCF VCRDCREPFH GGSFFDHEGL PYCETHYHAK
RGSLCAGCSK PITGRCITAM FKKFHPEHFV CAFCLKQLNK GTFKEQNDKP YCHQCFDKLF
G
//
