ID A0A182VF11_ANOME Unreviewed; 1692 AA.
AC A0A182VF11;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Rho GTPase-activating protein 100F {ECO:0008006|Google:ProtNLM};
OS Anopheles merus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30066 {ECO:0000313|EnsemblMetazoa:AMEM013856-PA, ECO:0000313|Proteomes:UP000075903};
RN [1] {ECO:0000313|Proteomes:UP000075903}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MAF {ECO:0000313|Proteomes:UP000075903};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles merus MAF (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEM013856-PA}
RP IDENTIFICATION.
RC STRAIN=MAF {ECO:0000313|EnsemblMetazoa:AMEM013856-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR STRING; 30066.A0A182VF11; -.
DR EnsemblMetazoa; AMEM013856-RA; AMEM013856-PA; AMEM013856.
DR VEuPathDB; VectorBase:AMEM013856; -.
DR VEuPathDB; VectorBase:AMEM21_003499; -.
DR Proteomes; UP000075903; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00030; C2; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR46150; RHO GTPASE-ACTIVATING PROTEIN 100F; 1.
DR PANTHER; PTHR46150:SF3; RHO GTPASE-ACTIVATING PROTEIN 100F; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
FT DOMAIN 78..148
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 689..813
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 853..1053
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 161..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 609..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1053..1164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1250..1316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1351..1370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1549..1595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1622..1692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..224
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..635
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1053..1067
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1081..1107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1114..1164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1250..1288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1566..1595
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1641..1682
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1692 AA; 176174 MW; 174F7740274F3E71 CRC64;
LLQGDFRKVS GISSEIFRQI EAVENDHDPS TAAALEVVER RGEMIVRILE PRCMGSRQAI
EAGQKFLNKS DARHTVQLVE IVKRPGQTLG LYIREGNGAD RSDGVFISRI ALESAVYNSG
CLRVGDEILA VNLVDVTRMS LDDVVIIMSI PRRLVLAIRQ RRGNRGSNSP GPPQMSRPEQ
KPPPVVVIKR DLRDEDLDDS DRAPRSSRSS RERRTGDGRE MTESRSRLGL GLNNYSPQSE
QLDLYYGAGR GPGGGPGPAE TPNWGYKPPA PPSSVITEQP KGMHGGFQTS HSYYQNAGTL
ESLAEKVHAF YPSATTSRRM SAGPAGVAMS QSHQRFPRSG SDQHLPRVEY ADYASLGRHP
LLARSSLKSD LVGAAPIAGG TLGRYGRYDA PPPQSRAPKY GPSPLGATGS LQRRSRPALD
YSSDTEATIG PRPSYYYYNH PAMAASGTMG GRGSTQALGG GPEFAKFNSL PRERPGATRL
GLRGRITDRL QDEADGNVSA PEYSLPIRRD IRDLRNRITA SPSIFTSDEY RAWLRRAPSS
SAICEQMRAS RDLLNQQRAH RFSCSAENIH DVLKNTEHIY SSRTGLGMGG AGAGGGVVGG
TLDRHSMAAG GPRMSSLPVR SLSSQHIGGP SSIRSPSVRR MRQLLELTQG AGVGGVPGSV
VAALTGHQSP APTPSTTLPR AHRQIDINPA EYTKYKLDKP VVDAVGMSGM LWIHLLAGRG
LRAMSETSQI QQPLIRDLYC VLECDRIHKA RTVVRSGDLQ FDWDESFELD LVCNKQLDVL
VYSWDPQHRH KLCYRGALSL TTLLRQSPIH QLALKVEPRG TIYLRLRHTD PFQLFRRRGL
PSLRGNVPAL FGADLETVVT RESKGAPGCA PVPIILRRCV EEVERRGLDI IGLYRLCGSA
TKKRLLREAF ERNSRAVELT PEHVPDINVI TGVLKDYLRE LPEPLFTKCL FQMTVDALGV
CLPDDPEGNA KLMLSILDCL PRANRATLVF LLDHLSLVVS AAERNKMSAQ ALATALGPPL
MLHSASVGAN EEIDHAQPIA VLKYLLQIWP QPGTGTGAPT SGNPHPSEVS AGLAERVQSP
HHATPSPSSS STSSASGSGS GTDTIKRGAS PASVKFKEST SNYSLKSDTQ SRILGGARQH
SQQPSYTTAG GASISSSNGG NGASGTGATS YDLLHARTGG LFASSAGTDY LSSTSSIASS
IASSAAGAGA ATSAAGLYGK VGGGAAATSA PLTSTLNITT FSLDEKNNLV VSPSPSSASE
SSYRSSSPAS SIQRDKSPNK SSGSPSPLRR QEPLDRADSL PATGATSGPG TSAASTVAAT
TASSGAGSFM SSLRSQTLGS YQFPSTSLKL TSQLSSGSSG QDASDDGSTS SLLRKLTSSL
SRTIVSNTGT LPLSLGREKL AELSSTAGGG TGATAGSGSA GAYSSSSGIG SISSSISSSI
GSSNASGSGL RTMSTSLGYS GIGGGASTLD GGAGGVGGSS SGSSSVTTAA AVTSMNIYGT
LPKNSSIYSS YGVGSGTSVS GSSGSGLSGL LSGTTSSYGI SERLRALTSG GSVGDGAADR
STGGVESAGG TGSSAGDLES SGYDYESSGF SSASYSGMAT SGASIGSGGG LSSSYFSTGS
NSSPFATMSG GGGGGGGAGG SGTGSTATDT NPYRVQYSST NPFLPSFNPT SDGSNGRADS
KTSNGDEPFD MK
//
