ID A0A182VGV2_ANOME Unreviewed; 3514 AA.
AC A0A182VGV2;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 2.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=E3 ubiquitin-protein ligase hyd {ECO:0008006|Google:ProtNLM};
OS Anopheles merus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30066 {ECO:0000313|EnsemblMetazoa:AMEM014752-PA, ECO:0000313|Proteomes:UP000075903};
RN [1] {ECO:0000313|Proteomes:UP000075903}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MAF {ECO:0000313|Proteomes:UP000075903};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles merus MAF (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEM014752-PA}
RP IDENTIFICATION.
RC STRAIN=MAF {ECO:0000313|EnsemblMetazoa:AMEM014752-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR STRING; 30066.A0A182VGV2; -.
DR EnsemblMetazoa; AMEM014752-RA; AMEM014752-PA; AMEM014752.
DR VEuPathDB; VectorBase:AMEM014752; -.
DR VEuPathDB; VectorBase:AMEM21_012246; -.
DR Proteomes; UP000075903; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:UniProt.
DR CDD; cd14423; CUE_UBR5; 1.
DR CDD; cd19675; UBR-box_UBR5; 1.
DR Gene3D; 1.10.1900.10; c-terminal domain of poly(a) binding protein; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR036053; PABP-dom.
DR InterPro; IPR002004; PABP_HYD.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR047503; UBR-box_UBR5.
DR InterPro; IPR024725; UBR5_UBA.
DR InterPro; IPR003126; Znf_UBR.
DR PANTHER; PTHR46276; E3 UBIQUITIN-PROTEIN LIGASE UBR5; 1.
DR PANTHER; PTHR46276:SF1; E3 UBIQUITIN-PROTEIN LIGASE UBR5; 1.
DR Pfam; PF11547; E3_UbLigase_EDD; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00658; PABP; 1.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00517; PolyA; 1.
DR SMART; SM00396; ZnF_UBR1; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF63570; PABC (PABP) domain; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS51309; PABC; 1.
DR PROSITE; PS51157; ZF_UBR; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1376..1460
FT /note="UBR-type"
FT /evidence="ECO:0000259|PROSITE:PS51157"
FT DOMAIN 3021..3098
FT /note="PABC"
FT /evidence="ECO:0000259|PROSITE:PS51309"
FT DOMAIN 3230..3514
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ZN_FING 1376..1460
FT /note="UBR-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00508"
FT REGION 84..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 292..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 658..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 726..803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1114..1140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1230..1257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1493..1523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1783..1910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2065..2089
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2296..2318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2430..2504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2524..2610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2911..3026
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3142..3192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 732..756
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..803
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1242..1257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1493..1510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1822..1850
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1854..1886
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1887..1906
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2304..2318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2430..2446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2473..2487
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2488..2504
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2540..2562
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2576..2606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2950..2978
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3142..3185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 3483
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 3514 AA; 368933 MW; 3A6DDCF65AC877A6 CRC64;
MSTLHFVVHP LPGTEDQLND RIRDVADKIN KYGVQTLPGL QSLKVPVKQI VIGPAHLGIL
LEDGRAFRVA FSIIPERLDL SKQDASKAGG AGGGGGGGGG GGGGGGGGGG GGAGGGGGGS
GGGGGNQTSN QSNNNSKSTP TSRQCRSRAR IMRTSSSVRA GSGSQASGSR STGVIMGGGS
SGSRSIVSVP APFVPEELVA QAQVVLQGKS RNLIIRELQR TNLDVNLAVN NLLSRDDEGG
DDTEEGSDNY VAEDLISLLD GGFHPDNSVI IDAEAMFTDD VFGFSNIRNR ARSERNQNNS
SSAGGSGGSG GAAGSAGNSN DGTPSGSRSG GGTQSGPGSG AGSSAVIAGG GQSGSSGGGG
AGGGPSGVSG GSGLSSAERE GFGRWRDRQY FGPRRWFQGG REDVWEKEAG DSKKKDYSSG
YPLWVSDEME PWPEKEHPVR FTEIASLYSE FIGVTARGEL HQWRWADAEP YRSSDAASVH
HPKTIPLNLL YEKVTHISAT LIRCSVATES GRIATWMDEL LGYAGNKLEH VATNYPEFAL
DRIVSLHTCT LYTVARTESG ELFWWGVLPF GQRKRLWDKY QAKAKKPIRP SVNAPEVTVG
AQVCMKSCPM YQHGAIGFTI SNGVPKVGQL MNAAWDLTKV CRFKLLSMST LSQQLAASTQ
GGSTGSGSGG GGGGGAGVGG GLGSSSSLGS CGIAGSLGSG TNAGGTGSQN ASAGVAGGIG
GLFEKDSKGG SGSGGASGSS AGSAGVSSSK QGAGNNKESA DRIDMPPPPS PASSTCSDTG
SVTNSHKRPK RMTLKEEPDS KKDEEQWLLK DVIFVEDVRS VPIGRVLKVD GDYAAVKFPP
PPGASTSNSS GSNSKDKFDD IEAWQDCRLL RKDDLQVIKS AATPRVPDCF QKIPRRIVLN
PSAAASSGGS DAAAGGGGGT SQLLTIAVDP KGIHGIMKTA NNRLHYSLFN LNTGRQEQDS
AFPTDIGSFL GASMQDVSLT CAGDSSDSVL LLRDGNNTIY PMAKDCMDAI RDPSWLDLPP
IKCIAAASLT LPSVGVNLKS QVALVVLAPE QQLLMAKILR CDIEGVRQLL AHIAADGPEQ
MRGTLAAILA EHTDGNRNII HACISMCSPT SNREPEFAAS GSNGNGGGGS SNGGGSAAGG
NNSGLESINV ITNTMIGNRP VSIREIMRRN VSNRELESSA SGGSGGGAGA IVSNNVQGAG
LAVPAGGGDD QQQVIGGNSM PVVYWPPEYD PASGDEDSLG GLNNAMGSQQ QQTGGAAGGS
QQAAALYTAQ KSLAAIPEAY VSDANERRQN AQLVLQLLCE SPVLQPHLRG LLSAKDAQGQ
TPFMLAVTCR AYQAGLTVFK AVQKIANGDD AVRDSMIFPP GSSPDQSPLG ILCCNDTCSF
TWTGADHINQ DIFECRTCGL TGSLCCCTEC AKVCHKGHDC KLKRTSPTAY CDCWEKCKCK
ALIAGNQAKR HDLLCKMATE TDLVTRFNSR GESILLFLIQ TVGRQMVEQR QYRATSRVRS
TSSGNARKTP NLEPDNEMPE HNLEPPRFAR KALDRLLNDW PAVRAMIMTG AENEKPIVPN
ANQQPFYDDD NQQVYLQSQS GTSLLDKFTH SLIVRCSSDP LEKLLMTLVH ELQNESIPGR
AEEAQKVARR FVRSVARVYV IFSIERFQNP EKQRNSTTQT KHLQAYRRVF TALFKFAIEE
LVEIADALIT PVRLGVVKPI APFNLSSNNI DSTDELFSVE PLAPPTNRAN AGGIAQIANT
TASVHLGVDP LDSERSSSGF ISRINIRLGD IEDNNDADAL VQDDGETSEQ EDMAEREQPP
PRRSSSLRPV ASAASMNAED ESQDLLRSEE NAQGESDNEF NFHEPETDSD SDDNQSTQDA
QRSVQTGATA GSDTGLNSLL FDNEDDSGDS TQPDDEGSED GESDDQSTVD FNLNDDQLER
RQTPGGNQRN NLAPQSMQWA IRSRETTAPE RVRLTTGSSN MVFIDPSSLR RSTAAVTTAQ
QQESPTMTTT ASALARAFGI ILRQISDLIG MLPTSITGSA SVLDVTHQDA VQLQMYVEKR
LKLTWEWILT VMEATEAQLR FGASLTDSTD PSHPLHPLNI PTSSSTSDAA PSALIGVTAG
RSRATISTLG TATTARSLGF ADNDRSAREG GSSLTADSEA SRRDFLTYCL SLMRAHNSEH
RDSLPVLDVT ALRHVAYVLD AILFYMRATN DCDLDRTTTG SNVWDDQDEN ENEEAEEDIT
NSIVMDSDSV DEDVLSRPSL GRRHSFFQRS DSTLCLGCPA PDPFNTPLTE ALPLADQPHR
LQPTAKREDL FGMPKWPITL APGGSGTPNP NTACSSEGGA CSATNLELPP VRLSLSSSIR
HEMSSSSSSG SGAAAASAAA TGIVIDPTEA LYSDAQQQQQ NQPSTTGQES SVAFISGGIT
QSSSPPSTDS RVRVEISLPV GIFQAAASGS ATVGNGSSTK QQQDMDASGI GGVAAGVNSG
AAAAAKSGGG ETHSPKPPPP PPPPSGGSSS GAGGSATASS SAASFSEVYY KKSRLFYLKS
NNKYSEESDV DEDHDELSES DSEDSRQHSS TSTAKRQKLD DGGSDVGGGA DEANAALSMS
LQQQQGSEQH QQQQTPQQQQ ESASAIRPPI IVTRRKVATT AAGGSASLDG SSVVLGQGSG
AADVAMPGEQ QIVAVAASSS SSSGPSVSFA NPLVTISNAP AGTSPGKSVI VRAGPSSTVF
AAGTIGSSGS SSNSVDLIQS AEAMDIQEIS AHVTVETTPN VLPAALQPEM PPRGIYLRGS
SAMSSSILSD ILLGRWRLSL ILFARVFLED VGVEPGSVIY ELNGFPVKET KFRRYMEKLR
CTTQKDLTLL KMERNRAALL TQTFKELNGL YNNRRVQQPL VFNRVKVTFK DEPGEGSGVA
RSFYTAIAEA LLANEKLPPL DAAQTPSKYG AGPFNSMLRH RGSGGGGGSA GGSAGSGSSN
AGAGVGGVVG GSSSIQQGSG AGGSSSSRRG LSSKQPLWRP NRESRKTLNY DARPFRPGSE
QSAAGGGGGS SGAGSGGSGG GASPPTLLNV GDIFSVQQQQ LGERLYPKVQ QQHPNNAAKI
TGMLLELPPT QVLHLLASDE NLRQRIGEAV EIIVQRQRLE MDNLSNGGAS GQSASSAAAA
AAAGTGGASA AAQGVSSSLG GSVSLTGSGS SASGSSGAAG TTGDQGGVTG SGVTGSSSSS
GGGGGYGSMA GQGGGSTPAL AKKCTPVLLL EDCQMDAPLF YTPGKRGFYS PRQGYPSSER
MNAFRNVGRL IGLCLLQNEL FPLFLQRHVL KFILGRQIRF HDLAFFDPVV YESLRQLIKD
SQTKTGISIL QSLEINFVID LMVEEGSGTV ELVPGGRDIQ VNENNVYDYV RKYAEYRMIK
TQEKALEAIR SGVFDVLPDT ALDQLTAEDL RLLLNGVGDI HVATLISYTA FNDESNEPSE
KLTKFKRWLW NVVEKMSNLE RQDLVYFWTG SPALPASEEG FQPMPSVTIR PADDSHLPTA
NTCISRLYIP LYSSKAVLRH KLLLAIKTKN FGFV
//
