ID A0A182VI22_ANOME Unreviewed; 1318 AA.
AC A0A182VI22;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Transient receptor ion channel domain-containing protein {ECO:0000259|SMART:SM01420};
OS Anopheles merus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30066 {ECO:0000313|EnsemblMetazoa:AMEM015328-PA, ECO:0000313|Proteomes:UP000075903};
RN [1] {ECO:0000313|Proteomes:UP000075903}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MAF {ECO:0000313|Proteomes:UP000075903};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles merus MAF (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEM015328-PA}
RP IDENTIFICATION.
RC STRAIN=MAF {ECO:0000313|EnsemblMetazoa:AMEM015328-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR STRING; 30066.A0A182VI22; -.
DR EnsemblMetazoa; AMEM015328-RA; AMEM015328-PA; AMEM015328.
DR VEuPathDB; VectorBase:AMEM015328; -.
DR VEuPathDB; VectorBase:AMEM21_004493; -.
DR OrthoDB; 5406916at2759; -.
DR Proteomes; UP000075903; Unassembled WGS sequence.
DR GO; GO:0034703; C:cation channel complex; IEA:UniProt.
DR GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR002153; TRPC_channel.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR PANTHER; PTHR10117:SF47; TRANSIENT-RECEPTOR-POTENTIAL-LIKE PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR SMART; SM00248; ANK; 2.
DR SMART; SM01420; TRP_2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 346..366
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 378..399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 561..584
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 648..670
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 157..189
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 192..254
FT /note="Transient receptor ion channel"
FT /evidence="ECO:0000259|SMART:SM01420"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 894..930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 983..1246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1028..1050
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1053..1088
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1089..1106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1220..1246
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1318 AA; 145899 MW; 77A06C17CA7C03F8 CRC64;
MGNEKKDPGG VGVQIESPSP VPSGCGGSAA FNMITNINLP VPLSLEEKKF LLAVERGDLA
SVKRILQRAH RRRNVNVNCV DSLGRGALTL AIENENLEMV ELLVIMNVET KDALLLAINA
EFVEAVELLL EHEELIHKDG EPYSWQRVDI NTAMFTPDVT PLMLAAHKNN YEILKILLDR
GATLPMPHDV KCGCDECIRR SSEDSLRHSL ARVNEYRALA SPSLIALSSQ DPLLTAFQLS
WELRNLAFAE QECKSQYLEL RHQCQNFAVE LLDQSRSSQE LAIILNYDPE SPPYMDGDHM
KLTRLELAID YKQKKFVAHP NIQQLLAAMW YEGVPGFRRK SAVEKIAIIV RTAVLFPIYC
MLYMIAPSCE TSKFMRKPFM KFLIHASSYL FFLFLLILVS QRAEVQVVLL FGTESMKRAL
QEELARQRGN GPTYLECLVV IYVMGFIWEE TQEIFKEGIR SYLRNMWNFI DFSRNFLYCC
VALLRVVAYI QQTSQISADP STAYIAREHW DDFDPQLIAE GLFAAANIFS ALKLVHLFSI
NPHLGPLQIS LGRMVIDIVK FFFIYSLVLF AFACGLNQLL WYFADLEKSK CYSLKGGLPD
WDNQGDACMK WRRFGNLFES SQSLFWASFG MVGLENFELQ GIKSYTRFWG LLMFGSYSVI
NVIVLLNLLI AMMSNSYAMI DEHSDTEWKF ARTRLWMSYF EESSTLPPPF NIFPNMKHVM
RLFGKKKKRD LKRESTIRRK EDKERAERYT NVMRALVWRY VSAMHRRMEQ DAVTEDDINE
VKTEISAMRY ELLDIFEKNG MDVSAVDRKE KAVLAKRMKI WERRLMKDFQ VAPVEMTEQE
AEEEEEEDAN PLARFRRVAK KVANNTTSAK WGQVMTGVGV EINTQIGRCR NRDSFRQQQQ
LQKAMAEARR LVERSPLPRS RSASPGIEAY ADETTTTLLN LLSQLAEEGD ASPGNTLNLH
DAKSGAATPL NMLTAQLQAA LSKTPSPCMG KSPKPAGGGL SVATGGGRSR SPGGLSRLEG
PSVASKSPLA SIAGSKSPSP DGTPAPEKKN NLQVKSPPPP PIMSPPPCKS PPPSTVQSPP
PPILQSPPPT IHITRTESQL VKKQSGSKDS NECEEEAGAP SSPPPAAEVP TVVHSDDPDP
LVSGVNSPPK VIKRKAPAPV PSTSTGEDIA VARPVAVKPQ PGQGMLPPPP SKEDGGAAPA
GTIIPTLSTT PATPLPSHKA VAAPRPPSPS APPKVASPPP TIASPPLVPL IKTELMADGE
PSEAAKSCST GSKESLIVGG GDASADAARA ASSPVCLRPY RKVDDVTTIK RQPKSGWL
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