ID A0A182VKL3_ANOME Unreviewed; 2333 AA.
AC A0A182VKL3;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Protein sidekick {ECO:0008006|Google:ProtNLM};
OS Anopheles merus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30066 {ECO:0000313|EnsemblMetazoa:AMEM016556-PA, ECO:0000313|Proteomes:UP000075903};
RN [1] {ECO:0000313|Proteomes:UP000075903}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MAF {ECO:0000313|Proteomes:UP000075903};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles merus MAF (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEM016556-PA}
RP IDENTIFICATION.
RC STRAIN=MAF {ECO:0000313|EnsemblMetazoa:AMEM016556-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR STRING; 30066.A0A182VKL3; -.
DR EnsemblMetazoa; AMEM016556-RA; AMEM016556-PA; AMEM016556.
DR VEuPathDB; VectorBase:AMEM016556; -.
DR VEuPathDB; VectorBase:AMEM21_009593; -.
DR Proteomes; UP000075903; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00063; FN3; 13.
DR CDD; cd00096; Ig; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 19.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR PANTHER; PTHR44170:SF49; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 13.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF13927; Ig_3; 2.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 13.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 7.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 13.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2095..2117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 121..202
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 310..404
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 408..493
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 502..588
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 593..682
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 689..795
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 800..897
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 902..1027
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1031..1125
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1129..1224
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1229..1346
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1351..1448
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1452..1545
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1550..1646
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1651..1753
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1758..1879
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1883..1975
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1978..2077
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 58..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2206..2269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2226..2241
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2242..2258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2333 AA; 257574 MW; 0107A2F01E6DBA35 CRC64;
MERNSQPSSG SQCSDQPQPP AKMFQEKFQR YVRHTAPVLC WWIAARQDGL PVTTCTKAHQ
SRRRPRGRRR TPVWGGGAPR TTLTTVSMHL LLMLLLCVSR DSTDGTVSAY SLSPDTQLQA
PRFTTQPSSS GSIVNEGRTK ILQCHALGFP QPTYRWLKNG VPVGNFSSSQ YLKILNITRD
DAGSYQCEAS NKAGTIFSEK IDVVVAYMGV FVDQSESIIS VASGYPAILN LSFIESVPSP
SVTWQTDEGP LEYNIKYAQT SSNQLIILSA DEGDIRAYRA RAFNTQIGRE ESTGFVRLNV
TGNPYTEIAP EIIVHPQNTK VVRGSQTVEL ECIANARPLH ELETIWLKDG IPIENTGIHY
TQTDPWNRTV TLLHVNLTHT GEYTCQVQMR TGGHPIVFSM AQVTVQEPPT FVTPLRTETL
GEYGSRTVLA CDVIGEPLPK ITWFKNAWPI EQVAGRYTVQ DDNSLEIYKL GMDDTAMFQC
LATNEAGEKS AYTWLKVKTS IPFMEIPPVN QTILDGKDAT MNCRAIAAPT PSIQWIFNDT
YPIETSSRMQ ILDSGDLLIS NVRETDGGLY TCIRENEAGR VIGSGYLTVL VRTQINRPPA
DTTVLLGHSA ALECGVSSDP TVPYNIDWYR EPNRLPIKNS QRIGVKKDGT LEITEVRPSD
VGQYSCIVTS PGGNETRSAR LSVIELPFAP SNVQAVRLTT PQNRAINVSW TPGFDGNSKI
IKFIIQRREV PELGPLPDPL LNWVTEVANV SAQAKWMLLT NLKAATAYQF RISSVNRVGE
GSPSDPSNVV KLPQEAPSGP PVGFVGSARS STEIIIQWQP PLEEHRNGQI HGYIIRYRLF
GYNESPWNYR NITNEAQRNY LIQELITWKD YVIEIAAYNN MGVGVYTDGA KIKTKEGVPE
APPTGVRVQA INSTAIRIWW TPPNPQQING INQGYKLQAW RYEKPPTLGA GGGGAIASGT
GDDGNELIET EMKVLTVPPN LLDPLAEQSE VLSGLEKYTA YNITVLCFTD PGDGERSVPV
PVQTLEDVPD EVSSLQFSGV SDREVTVTWD PPRRTNGVLL GYQIRYYVKD LPETARFVNL
TATQTRYKVT HLTATTHYTF EVSGWTVVGA GPPKVATIQS GIEPVLPHPP YQLALSNIEA
FSVVIQFTPG FDGNSSITSW IVEAQTARNL TWFVVHELQD PDASTVTVLG LTPFTTYRLR
IIACNVVGRS EPSEATKDFQ TIQARPKHPP FNVTVRAMSA TELRVRWIPL QQTEWYGNPR
GYNITYRNIH ESETFGSGES IATSLEDSEK SIWSSGRSVV IEDPTANSHV LDGLEEWSVY
EIAMTAVNEV GESIDSPHAF ERTREAVPSM GPAGVEANAT SSTTIVVRWT EVPKVHRNGQ
IEGYRVYYGS VAGRTPVLHK TIANNYTFTT TLTELKKFTQ YDIQVLAYTR LGDGALSTPP
VRIQTFEDSP GAPSNVSFPD VSFSMARIIW DVPEEPNGEI LAYRVTYLLN GSQNLNFTQE
FPPSDRTFRA TQLLAERYYL FSVTAQTRLG WGKTAAALVY TTNNRQIPQA PSAPQISRSQ
VQSEQITFSW TPGRDGFAPL RYYSVQLREN EGSWMLIPER VDPDVTSYTA TRLKPHTYYQ
FRIQATNDLG PSSYSRESVQ IRTLPAAPSE GITGLKVVPI TTTSVRVQWV ALRPSAWNGD
AETGGYRILY QPLSDFPSTL QSTPKMDVLG VNQVSAVLVD LTQDRNYEII LQPFNSQGSG
PPSSPVAVYV GEAVPIGEPL DIEGKAISST EVSLRWNPPQ QNTQNGELLG YKIFYLVTDS
STQDLDPVPA AVAGGINNGS AVRRNKPPEE EIEVVPASYN THNLVFLDKY TEYRIQILAF
NPAGDGPRSA PITVKTMAGL PGPPTQLHFS DITMNSLTVS WDLPRKRNGL IVGYIVAYET
TEDNEKFSKQ VKQKVTGTSL IVQNLEEEVT YTFTVRAQTI DYGPAISGNV TTGPQEGSPG
SPRDLMISKS QASVQMHWIN GQSGKGPILG YYIESKKRDD LRWETVARST NGPIQEFTVS
FQNLLPSTAY KFRVISYNRY GISCPVYSDD AVLTPSKLYL EYGYLQLKPF YRQTWFMVAL
AATSIVIVIM VIAVLCVKSK SYKYKQEVQK TLEESIAMSI DERQELALEL YRSRHGVSAN
GASNGITGVS GTMIHSTLGR RTGTILSRKG GGGGCSSTAA AAAAAASLGK SPPRPSPASV
AYHSDEESLK CYDENPDDSS VTEKPSEMSS SDSQASESEN ESVRSDPHSF VNHYVNNDLL
RQSWKRQKPV RNYSSYTDSD PEGSAVMSLN GGQIIMNNMA RSRAPLPGFS SFV
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