ID A0A182VRG1_9DIPT Unreviewed; 644 AA.
AC A0A182VRG1;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Cation/H+ exchanger domain-containing protein {ECO:0000259|Pfam:PF00999};
OS Anopheles minimus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=112268 {ECO:0000313|EnsemblMetazoa:AMIN000647-PA, ECO:0000313|Proteomes:UP000075920};
RN [1] {ECO:0000313|Proteomes:UP000075920}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MINIMUS1 {ECO:0000313|Proteomes:UP000075920};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles minimus MINIMUS1.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMIN000647-PA}
RP IDENTIFICATION.
RC STRAIN=MINIMUS1 {ECO:0000313|EnsemblMetazoa:AMIN000647-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|ARBA:ARBA00007367}.
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DR AlphaFoldDB; A0A182VRG1; -.
DR STRING; 112268.A0A182VRG1; -.
DR EnsemblMetazoa; AMIN000647-RA; AMIN000647-PA; AMIN000647.
DR VEuPathDB; VectorBase:AMIN000647; -.
DR OrthoDB; 3228646at2759; -.
DR Proteomes; UP000075920; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR PANTHER; PTHR31102; -; 1.
DR PANTHER; PTHR31102:SF22; NA[+]_H[+] HYDROGEN ANTIPORTER 1, ISOFORM A; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 149..171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 324..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 357..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 392..411
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 423..442
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 454..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 480..502
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 555..576
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 184..571
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT REGION 1..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..61
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..78
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 644 AA; 70491 MW; 085340797FA5B74C CRC64;
MPSEEGNASS QSSSGDTKRK VSIITEPVVE RLGHDNLGFE QNKRKISQQS HHSEEGPARR
KSNLHNNNFD TSSIHSDRYN GEAGGRAKKQ SFSEALEKIE KDYDNSRLEQ SWIYSLCMRC
RVEYTTPSWE PPGWQKICPY PLCPSYRQFA RILSIILIGV LLWITAFVII GDTAAPGGQL
FQLVVLTVAA NFGGFLISLT TLPRLIGMLL VGILFQNVGW VNLDGEFQIV TAELRKLALV
IILVRAGLEM DPTAFKKIYK TILKLGLIPW FVECSLIAVC ARFFLQLPWM WSILLGSIVG
AVSPAVVVPC LFRLRTKGYG VVKGIPTLII AVAGIDDAVS VAGFGIISSI MFSTQSLGLQ
IAQAPVCIIG GLGFGVVWGF LCKYVPEPGD AYVVPIRTLM LFGGGLLAVF GSEEINFEGA
GPLGVVFAAF TASYFWCGQG WELEDNPVST AFEIFWMIFE PILFGITGAS IKIAELDPHI
VSIGVGSIYV VAVIRILTTV AIAFGDKLNV KEKIFVAISW MSKATVQAAL GPVALKTVMS
NENRTEEEVH YAEMVKMVCI MSIILTAPLG AILISVTGTK LLKKTKQQLE PMDGWRRSHR
PSLHDISIID EEEEREDIEG IADEDTAANT LSNAQTATAF TITK
//
