ID   A0A182VRH7_9DIPT        Unreviewed;       757 AA.
AC   A0A182VRH7;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   RecName: Full=FHA domain-containing protein {ECO:0000259|PROSITE:PS50006};
OS   Anopheles minimus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=112268 {ECO:0000313|EnsemblMetazoa:AMIN000664-PA, ECO:0000313|Proteomes:UP000075920};
RN   [1] {ECO:0000313|Proteomes:UP000075920}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MINIMUS1 {ECO:0000313|Proteomes:UP000075920};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles minimus MINIMUS1.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AMIN000664-PA}
RP   IDENTIFICATION.
RC   STRAIN=MINIMUS1 {ECO:0000313|EnsemblMetazoa:AMIN000664-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A182VRH7; -.
DR   STRING; 112268.A0A182VRH7; -.
DR   EnsemblMetazoa; AMIN000664-RA; AMIN000664-PA; AMIN000664.
DR   VEuPathDB; VectorBase:AMIN000664; -.
DR   OrthoDB; 2787263at2759; -.
DR   Proteomes; UP000075920; Unassembled WGS sequence.
DR   GO; GO:0030870; C:Mre11 complex; IEA:InterPro.
DR   GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR   GO; GO:0007095; P:mitotic G2 DNA damage checkpoint signaling; IEA:InterPro.
DR   CDD; cd22667; FHA_NBN; 1.
DR   Gene3D; 2.60.200.20; -; 1.
DR   Gene3D; 3.40.50.10190; BRCT domain; 1.
DR   Gene3D; 3.40.50.10980; Nibrin, BRCT2 domain; 1.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000253; FHA_dom.
DR   InterPro; IPR040227; Nibrin-rel.
DR   InterPro; IPR032429; Nibrin_BRCT2.
DR   InterPro; IPR043014; Nibrin_BRCT2_sf.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   PANTHER; PTHR12162:SF0; NIBRIN; 1.
DR   PANTHER; PTHR12162; NIBRIN-RELATED; 1.
DR   Pfam; PF00498; FHA; 1.
DR   Pfam; PF16508; NIBRIN_BRCT_II; 1.
DR   SMART; SM00240; FHA; 1.
DR   SUPFAM; SSF52113; BRCT domain; 1.
DR   SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR   PROSITE; PS50006; FHA_DOMAIN; 1.
PE   4: Predicted;
FT   DOMAIN          17..66
FT                   /note="FHA"
FT                   /evidence="ECO:0000259|PROSITE:PS50006"
FT   REGION          330..477
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          491..510
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          586..624
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        343..363
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        364..394
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        404..440
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   757 AA;  84025 MW;  68AF5D5B8090111E CRC64;
     MFIPEYVYYL VSQSTGHTVG RTGTNLIIAK DDSISRNHAL LQPQNNVLHL TDTGSRYGSY
     VNDNIAKTVP ISKDQPTVLK PGDMIRFGRC GSTWQVGRVH FRCLTSMLTM NEALKTILQK
     IEAELVSSYT AGLTHLIMPS ITVTTKLLHC LVGQVPIVKP EFFQTIEKDC IGEGKPIPSV
     KDFLPICTEE RFVNKQHLFH PHSTRSNLFQ GKEFIFLNNA QYSQFANIVQ LAGGVCLSAH
     REKVAKSRLL KANVIIIKLN PSDSSQSQSQ SFGSLSQYLD ARGRRMVPDI EIGLALMFCS
     TEKYCNPEYN FPFSAEDCKK FEEDGEILAK NTELQTENTN AKATKEPKID TIPETEPHTE
     EKQGARLANN QPMASSSKTN NISTRSTSSF LIPKVVSPPG NVPAERRKSK RMQETVRGEE
     RTSVQEADNR PKRPRRNDTP VESVDYSPVV DSNLTETERG GSELHIPETQ PTTDSDLSQA
     LQARGFRAVN RDSMEPNGQT GKEPAKAKRA ADVHRQLDEN DLFVFDEIVP RKKPRVAKSN
     ENGISHTARN TRNAPTEEEN LFCFEGASTT QQRRTANQHK ANKTVPLGAS KNNLTNSSPI
     VSSDAASSRT GGVQNRSTSN GSTLDSYREF IKPVQPSATG WLSSTMRGLK IAENGEESSF
     SEMQIKSEPL DEVDDPYGML EETKKWSKSV ANAIHVREKS MKLVAHRPID VSGHELSCVA
     SDGGKNFKAF VKKRNYPAQQ VVLSTKSVCV RDENQCA
//