ID A0A182VT77_9DIPT Unreviewed; 1867 AA.
AC A0A182VT77;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Kinesin-like protein unc-104 {ECO:0000256|ARBA:ARBA00020751};
OS Anopheles minimus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=112268 {ECO:0000313|EnsemblMetazoa:AMIN001267-PA, ECO:0000313|Proteomes:UP000075920};
RN [1] {ECO:0000313|Proteomes:UP000075920}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MINIMUS1 {ECO:0000313|Proteomes:UP000075920};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles minimus MINIMUS1.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMIN001267-PA}
RP IDENTIFICATION.
RC STRAIN=MINIMUS1 {ECO:0000313|EnsemblMetazoa:AMIN001267-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR STRING; 112268.A0A182VT77; -.
DR EnsemblMetazoa; AMIN001267-RA; AMIN001267-PA; AMIN001267.
DR VEuPathDB; VectorBase:AMIN001267; -.
DR OrthoDB; 126886at2759; -.
DR Proteomes; UP000075920; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd22705; FHA_KIF1; 1.
DR CDD; cd01365; KISc_KIF1A_KIF1B; 1.
DR CDD; cd01233; PH_KIFIA_KIFIB; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 6.10.250.2520; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR049780; PH_KIFIA_KIFIB.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF5; -; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16183; Kinesin_assoc; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00129; KISc; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}.
FT DOMAIN 3..351
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 1717..1815
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 426..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 930..950
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1127..1159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1638..1664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 359..386
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 653..702
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 930..949
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1142..1158
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 97..104
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1867 AA; 208339 MW; 4B0CBB5A99197606 CRC64;
MSSVKVAVRV RPFNSREIAR ESKCIIEMSG NTTCITNPKV PPGSSESVKR FNYDYSYWSH
DPRDLEFSTQ AMVYSDIGEE MLQHSFDGYN VCIFAYGQTG AGKSYTMMGK QEDSQEGVIP
MICKDLFRRI QETESDDLKY SVEVSYMEIY CERVRDLLNP KNKGNLKVRE HPLLGPYVED
LSKLAVTSYQ DIHDLIDEGN KARTVAATNM NETSSRSHAV FTIFFTQKRQ DRMTSLETEK
VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEIAS KNKKSKKADF
IPYRDSVLTW LLRENLGGNS KTAMIAAISP ADINYDETLS TLRYADRAKQ IVCKAVVNED
ANAKLIRELK EEIQKLRELL KAEGIEVQEG PDGKVVCEKR DANKDECLIK SDKIESVGGV
VITEEGEDGE KKIHSPNRNR KRTGSSTEMA VDQLQASEKL IAELNETWEE KLKRTEQIRV
QREAVFAEMG VAVKEDGITV GVFSPKKSPH LVNLNEDPTL SECLLYYIKD GLTRLGTSEA
NVPQDIQLSG SHILKEHCVF ENKDGVVTLV PHKDALVYVN GRKVIEPEVL QTGSRVILGR
NHVFRFTHPE QAREKREKNK EVDVCETPGN SGEIADWNFA QCELLEKQGI DLKAEMEKRL
LALEEQYKRE KRAADQEFEE QRKTYEARID ALQKQVEEQS MTMSMYSSYS PEDFHQEEDI
FVNPLFESCW TAREAGLAAW AFRKWRYHQF TSLRDDLWGN AIFLKEANAI SVELKKKVQF
QFTLLTDTLY SPLPPELTPA PAVGALTNGG QEDEFGQTPI PRTIVAVEVT DTKNGATHYW
SLEKLRYRLE LMRQIYNTSD TSPELMSFVL ELSSGEHTPE HSGTQHPAFA HPPLSVSKQQ
QDHHVAEQPA AARLLGGLAP NCDGGKCLSS PTNSVASNSS SSCGTASPPS PPSVIFDGDA
ATSISSCSFG RAGTRLTLAN LMPSRQRLEL MREMYHNEAE LSPTSPDYNV ESLTGGDPFY
DRFPWFRMVG RSFVYLSNLL YPVPLVHKVA IVNERGDVRG YLRVAVQPVM DEENADFSNG
VKQSARILFD EEQNGQHKVP KIRTIPDKDE KYIEGGNDMG TKLEELEQED ADSGRGDSSV
ASELHESNDQ EPGEHLQPGK EFTFRVTVLQ ATGIAAEYAD IFCQFNFLHR HEEAFSTEPV
KNSGSGAPLG FYHVQNITVP VTKSFIEYLK TQPIVFKVFG HYQHHPLHKD AKQDCQITRP
PPRRMLPPSI PISQPVRSPK FGPLPCPPSS TVLAKHDVLV WFEICELAPN GEYVPAVVDH
SDDLPCRGLF LLHQGIQRRI RITIVHEPTP EVKWKDIREL VVGRIRNQPE PADDEDSDSC
VLSLGLFPGE VLEVPGDDRS FFRFEAAWDS SLHNSALLNR VTQTGEQIYI TLSAYLELDN
CARPAIITKD LSMIIYGRDA RTGPRSLKHL FSGQYRNPEA NRLSGVYELS LRRASEAGSP
GVQRRQRRVL DTSSTYVRGE ENLHGWRPRG DSLIFDHQWE LEKLTRLEEV GRVRHLLLLR
ERLGMDTTPN PTTKTEKDVC NLAQRASASP VHMVIPPSPQ TPVKDQQSPA LPERDLSVRE
TELVWKCVKL IQGRIGGKEL GADGNGSGTQ ASDASPGDEG CADMNASYIS SNSIELCSPE
RVDVPNGWEA PAPAPQTQEL SLRLYVPELE EIRVSPVVAR KGYLNVLEHG GSGWKKRWVT
VRRPYVFIFR SDKDPVERAV LNLATAQVEC SEDQAAMVKV PNTFSVVTKH RGYLLQTLGD
KEVHDWLYAI NPLLAGQIRS RLARKNISSI SSNGSGAGDQ LQATTGASAL AVAAAQGNGS
SSSSGGK
//
