ID A0A182VU75_9DIPT Unreviewed; 608 AA.
AC A0A182VU75;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 22-FEB-2023, entry version 26.
DE RecName: Full=IRS-type PTB domain-containing protein {ECO:0000259|PROSITE:PS51064};
OS Anopheles minimus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=112268 {ECO:0000313|EnsemblMetazoa:AMIN001618-PA, ECO:0000313|Proteomes:UP000075920};
RN [1] {ECO:0000313|Proteomes:UP000075920}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MINIMUS1 {ECO:0000313|Proteomes:UP000075920};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles minimus MINIMUS1.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMIN001618-PA}
RP IDENTIFICATION.
RC STRAIN=MINIMUS1 {ECO:0000313|EnsemblMetazoa:AMIN001618-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR AlphaFoldDB; A0A182VU75; -.
DR STRING; 112268.A0A182VU75; -.
DR EnsemblMetazoa; AMIN001618-RA; AMIN001618-PA; AMIN001618.
DR VEuPathDB; VectorBase:AMIN001618; -.
DR OrthoDB; 4212441at2759; -.
DR Proteomes; UP000075920; Unassembled WGS sequence.
DR GO; GO:0005158; F:insulin receptor binding; IEA:InterPro.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:InterPro.
DR CDD; cd01204; PTB_IRS; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR039011; IRS.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR10614; INSULIN RECEPTOR SUBSTRATE; 1.
DR PANTHER; PTHR10614:SF13; INSULIN RECEPTOR SUBSTRATE 1; 1.
DR Pfam; PF02174; IRS; 1.
DR PRINTS; PR00628; INSULINRSI.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51064; IRS_PTB; 1.
PE 4: Predicted;
FT DOMAIN 1..111
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
FT REGION 137..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 483..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..550
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 608 AA; 62694 MW; 625CC0B3CE3352AB CRC64;
HIWDVFVQRK GLGDSYGILG NYRLCSTDKI LSLNRIGPEC TPQQEKRADK VEFSLASIRR
CGHSQRYFYL EVGRSSKTGA GEIWMEVQDS IIAQNMYTTI MKSAKSKDDN LGPMIRIRSS
SANAASKPTS MLFRRQTHTG QKPINCSPSS EDQSNNATNS ESSSSATSIN TVVLVGSPPK
GSGANSSGAP NSKPRSVLVA NPTLPACEEN SLLGSCVNSS SNNATATSTI RTTSISFTTT
IISVTTATSS TITASMANSA MHTTIPESYH TPTIVPFAGH APTNSSAAAV CSTVASTSAA
MFTCSHSSTS SLTSIGSCSP SDAYVPLVPG AGRSASPNQH PLSVVAAGGS GGREANVSGR
GGLIGSPRLG VTAQSPSYRR MSLKKPTAKM EPVTSSPLLS SSQRTVCAIS TVNTSTANTM
ATSMTAAMMM LPPSPSASMS KFHHYASTRQ GGREVPCSGG GITFSNLLAT ITNSIVGSSG
GGGGNGVGGS GEGGSASGGS GSSSGGSFSN FSSSKSSSCC SSTVSIQTIA IPPMGPPAPL
PPPPLPPTPA ASALRGVRRH TRSLSHHSAN AIYLTSAKPL RRLRSTLRRH SVSERMIVTE
KEHIQCNI
//
