ID A0A182VUJ2_9DIPT Unreviewed; 746 AA.
AC A0A182VUJ2;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Homeobox domain-containing protein {ECO:0000259|PROSITE:PS50071};
OS Anopheles minimus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=112268 {ECO:0000313|EnsemblMetazoa:AMIN001735-PA, ECO:0000313|Proteomes:UP000075920};
RN [1] {ECO:0000313|Proteomes:UP000075920}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MINIMUS1 {ECO:0000313|Proteomes:UP000075920};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles minimus MINIMUS1.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMIN001735-PA}
RP IDENTIFICATION.
RC STRAIN=MINIMUS1 {ECO:0000313|EnsemblMetazoa:AMIN001735-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
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DR AlphaFoldDB; A0A182VUJ2; -.
DR STRING; 112268.A0A182VUJ2; -.
DR EnsemblMetazoa; AMIN001735-RA; AMIN001735-PA; AMIN001735.
DR VEuPathDB; VectorBase:AMIN001735; -.
DR OrthoDB; 2897127at2759; -.
DR Proteomes; UP000075920; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 2.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR000047; HTH_motif.
DR PANTHER; PTHR46255:SF3; HOMEOBOX DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46255; SHORT STATURE HOMEOBOX; 1.
DR Pfam; PF00046; Homeodomain; 2.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 2.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}.
FT DOMAIN 419..479
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 528..588
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 421..480
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 530..589
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 30..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 74..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 467..500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..245
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..379
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 746 AA; 80630 MW; 6AB7B3596F614855 CRC64;
MEQLAHFVTK SFDFNNSRVL DLLNMTATTG SISHPDYGAR TGSDSDLLSN TSSSLGGDLE
DEIHSHSLEV SHHRLHTLHP LRSNVPIADR NEKREEPSNE DEETIDIEIT DLSYSNASGG
SSVGVYDNDE HKANRPTHTL SMSSSISLVP TVVMSGDKAV ETSAQSEKNG DKNTTGCSLL
LLTGSNSSNN NEKGVTNRNE ISVIRKFDNK KTHENDRSSV ALRELPGDGT DDVRSGQRKE
SDKGSTGGDG GNVNGKSNSK RHVPRNWLIA DLVDEKKEDK TKDDVALNLV RSESDTRVAK
AAHGYDPTSM QVVRPKPASE LLKQSVDLIN NHHYPAGSIS NPGHHPPVST VAGTDGESDT
EARAPRESVT PDQEDPCADG SRSDSAPPAG ATVEERLKLP TESTHVTNGH GPLSALTNNK
QRRSRTNFTL EQLNELERLF EETHYPDAFM REELSQRLGL SEARVQVTNQ ARAPRESVTP
DQDDPCADGS RSDSAPPAGA TVEERLKLPT ESTHVTNGHG PLSALTNNKQ RRSRTNFTLE
QLNELERLFE ETHYPDAFMR EELSQRLGLS EARVQVWFQN RRAKCRKHEN QMHKGIILSS
HSPPVTTPLE PCRVAPYVNV PSLRAGNGVP PGGGTGGTGL SPSTTAATAA AAVNHHFPVA
AFSAFDSAFI SAAAQQYAAA LSSGTVPASL FSLSQYRPGG LAAAAAIATL PGFTVAHDKN
SSIVDLRLKA EKHKENQKKI VNNVSS
//
