ID A0A182VXI8_9DIPT Unreviewed; 2739 AA.
AC A0A182VXI8;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=C2 domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Anopheles minimus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=112268 {ECO:0000313|EnsemblMetazoa:AMIN002787-PA, ECO:0000313|Proteomes:UP000075920};
RN [1] {ECO:0000313|Proteomes:UP000075920}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MINIMUS1 {ECO:0000313|Proteomes:UP000075920};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles minimus MINIMUS1.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMIN002787-PA}
RP IDENTIFICATION.
RC STRAIN=MINIMUS1 {ECO:0000313|EnsemblMetazoa:AMIN002787-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the tollip family.
CC {ECO:0000256|ARBA:ARBA00009278}.
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DR STRING; 112268.A0A182VXI8; -.
DR EnsemblMetazoa; AMIN002787-RA; AMIN002787-PA; AMIN002787.
DR VEuPathDB; VectorBase:AMIN002787; -.
DR OrthoDB; 8630at2759; -.
DR Proteomes; UP000075920; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR CDD; cd04016; C2_Tollip; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR003892; CUE.
DR InterPro; IPR033053; Hir3/CABIN1.
DR InterPro; IPR037301; Tollip_C2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR15502; CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED; 1.
DR PANTHER; PTHR15502:SF7; CALCINEURIN-BINDING PROTEIN CABIN-1; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF02845; CUE; 1.
DR Pfam; PF13181; TPR_8; 2.
DR SMART; SM00239; C2; 1.
DR SMART; SM00546; CUE; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS51140; CUE; 1.
DR PROSITE; PS50005; TPR; 2.
PE 3: Inferred from homology;
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; Signal {ECO:0000256|SAM:SignalP};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..2739
FT /note="C2 domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008140404"
FT DOMAIN 125..236
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 303..346
FT /note="CUE"
FT /evidence="ECO:0000259|PROSITE:PS51140"
FT REPEAT 443..476
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1395..1428
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 722..751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 797..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1677..1781
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1795..1861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2105..2131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2265..2285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2338..2401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2427..2504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2579..2609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2636..2739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..738
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 797..818
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1678..1692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1704..1728
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1801..1837
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2338..2355
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2368..2401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2427..2454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2479..2493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2636..2699
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2712..2726
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2739 AA; 305433 MW; 102693F89EA0C17F CRC64;
MNMAPKFVFA SFLIITMLVC AFNALPVPDH AKIRIHVPIK HHTHLHTKTV VKTVHVGIPV
KNVKTHDDEH GWEYAMEEVT PRSNEHWKRA YLGPLPDEFL RVTTAQDIQE VSDRQAALAL
QSYHNTYTPH MAPNFVGRLS ITIAQAKLVK NYGITRMDPY VRLRVGHFVY ETQTAPNGGR
NPRWNRVIHC QLPAGVETIA LEIYDECNFS MDELIAWAEI RIPQSVLRGE THEDWYPLSG
KQGEGLEGSI DMVMSFNNMV VQPRMIQTNA PVVLVPNVAS GTPMPVFVAP NQPQVARLPP
PVLSDDDLTR IHEMFPQVDK EVIKSVAIAN NQDRDAVINA LLQMTRVSRN GAQSLNKTTK
MIRISALNEE ESDEDSNGFD TELIVTKEAE ETIAISEYVR ALQMKNENKQ QDALELLLEL
LDTQVINDVT TTQADNKLFA VKYNCYRNIG LIYEEQGKQH LAIEFLMKAM DLDETDVYTM
SRLAHMALKT GHLEISKMYF EKCLKRNPNH WPSMEGLLRV FCNACNVVEA YGWASQCHRK
DSRNKLYVDV LRAIRERFKS TLSYLDTVFL VPPTFDFTEE EKRRPLALAL ETFDELFKPY
PQADDSSDLT VMPETLKNVM KIDDLSFETI GNVLVKLNQL MEELDLKCVF MVDTDELFCE
HRKEKPEQME EDVQMSPDAT ECAADVSTAK DENRMEMEEE EICGEEVNDV GAAGVKCNED
ANGNGTSAAD SADSGVDANE QAKNKARRRG SELKILEQWG WHKNRRSTRK KSVQEVNDPV
DATADSFFKQ AVKQHLSEDS RFKESPFLSD EQGKEPENDP AGEVQPTESS MPITQLDFCR
ECNLRNFVAE MKASDIDVYA LMYGFLAHIS KSWGVAMKPE LRSLYLEVHS HFVQYTEYNS
WNQLSEDQLE VIYQITLFHL ELKLDAGLTR TNEQTASVFD QFDEEVFHRC RFYVDSLPNL
QTVTVYRIRL LWIAYILDCS MQKYDEALDN LYLILELVEA PGEPRIELSF PNQCANTSIS
GGSVRELIGE TERKLRIERV KRHYDNGDHE PVVAILKDTL QYYTTIGNPD ESILSLTIQT
QMLLESLWSM AEMEECFIWS EKSFTYSVQQ FMTAPVQHDS RKSRMWANNI NFALLYMESN
IKQEGVAIID VLGKNLSRLI QSLHRMLTHQ LDPSGEKNYT AQLCLIECWR AWIVLYYILE
RQDDMDSLVK LNRTPAIADQ CGALELEPDR LCNSIMMCFV AHELLGKKNW CSKGDSGLLF
HTLDVVVPKI RSPMLEPCRE ILNEYLEQVT YCLYGYPQKR PRLRHIQDHC AVQVSLTWER
AIQLFDLYRP DSLPEFNSYK LESISTDMEA LLQRIILLIP IEINVMKLSR PILEFIDGKG
NTLPEAANIL QSEVKPIFYL LADFYFKSRD FTRAISYYVK DLALEPSRFD SWAGISLSKA
SKVETKLNST ETIPLQEFLD ETDNGMKCFD QCLQLNEEDS QLWIEYGSFA YNIHSFCSRS
LKLLSDTLSM ESFALVETHK ERCLDIAFTC FNKVSLMKLC YSNAAGDIIE DQQLQSNQEN
GHNHEDEVWL HHYMLGKIAE KKKEHPAVYL THYLKSAKYL YECNATYPIK INHSSPSQLA
IEALEIFYRI NAAIIKYVEQ HSPINKKTSR LFLRTLKELS TSPFAVNRAK INENMLKRKI
SPNGNNGNAG GGGTTGDIEV SVGSPKVSKT SEQIPTESAL VTTSDAATLD ENKPRDVAES
TAAVLRNSPQ PTEPKSVASE MPPMVDETNV PSPVSASSQM PSRMLEHLRV EEIKQLGDPQ
NPSVRRGSQE SAITSTTTTT TTTTSTSSSS SDSSDSDTDT SSDSDSDSTS TDDELINQQP
ISPAQRDTIF KLCIKNLEEC ITRFPEHYKS MYRLIHHFMH APGTTKSFES ARQLLLGTYR
TTLGNQIPGL FTERKTTNFF NGLWRIPASD IDRPGNFASH ISKCVIVLME TLKEFSEYDV
LLELALQLQR TPEPDKKYLN DYERKELVQQ AILFCVQVYR SMLKKYTDGR NDTELLSLMV
DMYKAYRKII KHMQAKEPMF ATALVDAYRV FVSDKVPKLP ENVSLLDLAV KLCTYEINYR
KTQEKHQQAT GSAVTGTGGP GTGNGGNGSK PMLTSGELPA TMIVPMQPIS ANFIPGLTKQ
NRRLGVTKST IASTPTTTSE QSILQQHQQQ HGYPVPNPYA QTTMNNMMSD LSSRVTITPI
MLESATSATN VPNSSKVTTS TTASTTATKS LAFPTTATNE LLLPMATGSG MPLPSATPPA
QLSTPSVTAA MSSSSLYQQY LKLFSQIPNI ASISNNPMMT AAFTEYLAAF KMQKQKAALS
PSTDRSTSTP SPLSGMSLGL PKGIQSASGK EYNPTNIQQP VTGSKKASGT KATASSTITS
MNTDPHQQLA TITLTPMSTL TGIPAVTGTK DSRVSSPFGG SAQRVSSPSP ILTITPSEGP
IPARNKDPPS GRKMKGRKAG NTGQQTRPTP YSRLPNTTHP PIPQLGVPGL SIEPVMGPLM
QPMGGGKSSG SAANTGRVDK SLPAGMFDAG VPKDLLASYM ELLQKYPHMA RSLLLSMKGA
GTSSSPVAGT SQQTGGRKQS AKQSNKASTM ATMQSAMANM PPTGSVAVAN RFSSSPTSIP
RISATITPVS SGGYPTDNYN RQSTIVGASG TNSSSTMSLH SMGVSGSIHQ QAKTLQQKLA
ERQKANKARE TEGAGGSSQG TSSTKPKPAD DPVDVIVLE
//