ID   A0A182W1K5_9DIPT        Unreviewed;      2220 AA.
AC   A0A182W1K5;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   08-NOV-2023, entry version 30.
DE   RecName: Full=Rap-GAP domain-containing protein {ECO:0000259|PROSITE:PS50085};
OS   Anopheles minimus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=112268 {ECO:0000313|EnsemblMetazoa:AMIN004215-PA, ECO:0000313|Proteomes:UP000075920};
RN   [1] {ECO:0000313|Proteomes:UP000075920}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MINIMUS1 {ECO:0000313|Proteomes:UP000075920};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles minimus MINIMUS1.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AMIN004215-PA}
RP   IDENTIFICATION.
RC   STRAIN=MINIMUS1 {ECO:0000313|EnsemblMetazoa:AMIN004215-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   STRING; 112268.A0A182W1K5; -.
DR   EnsemblMetazoa; AMIN004215-RA; AMIN004215-PA; AMIN004215.
DR   VEuPathDB; VectorBase:AMIN004215; -.
DR   OrthoDB; 21929at2759; -.
DR   Proteomes; UP000075920; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   InterPro; IPR046859; RGPA/RALGAPB_N.
DR   InterPro; IPR027107; Tuberin/Ral-act_asu.
DR   PANTHER; PTHR10063:SF11; RHO GTPASE-ACTIVATING PROTEIN CG5521-RELATED; 1.
DR   PANTHER; PTHR10063; TUBERIN; 1.
DR   Pfam; PF20412; RALGAPB_N; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468}.
FT   DOMAIN          1859..2066
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50085"
FT   REGION          208..227
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          439..464
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          660..694
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          752..785
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          887..975
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1254..1281
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        449..464
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        669..694
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        752..767
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        893..917
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        920..975
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2220 AA;  241132 MW;  0AE40A4680D7AA67 CRC64;
     MFTKKANIDL KKSTQKIQDS KKDSAARLRH LKTILEHVDS DEAKNLFEAN YSHVYYILYD
     TFVQAEANLK QRVHKTHREE LDGSLWLLSK ILCLLPELVQ RRWQCHSLGR ILAKLLHYGN
     SVKLRREGVK YFLLWYQALG DNAPPFVHGM FTELVPGLSV PQRGKNAPAG PVPSDSEFIT
     TDLLNHPNLK GELGGSVFHD TTATHPVKSP EIQPLIPPSS SERTAAPDPR DGLEILLDCM
     VQSCGCLKWR DNSPQRHIRT FNFLLTKFRE QYLPVFCPTF DYSTSVYEPK LDLPVIRSVS
     KREEVMSSCV VVLIIWIAKY THERHVNSKL EQILSIEDEP SAGSGGGGSL DHASLLSNLR
     HMGYTQTQLV RDVLYSSRET VNFVHEIYRQ AFLMAFTSKS QIEAMRIAIS VYRDWMSSIP
     PPPFLLEPDL EALPVGGGSP GGGVGPTLET ISPTASNSRP GSQRLRTDSY LGAMMLTKEN
     GSIRAGLQNV LQVFVTNAVN VFMVNTAHLN LHFQSKTNAD GYATPLDEQT DICKRVLNIY
     RTMVMKTRME AKTWEQLLLV LLQVTSVILQ NSPPNAKKNN LGGRLAQPIF QTLIVTWIRA
     HTNVPVNAGL WDRFLKVLSS LTHREELIVE WDKTMQTLTR VLARQVYNIN LSDLPLDRLA
     EQKGKRKRGT PSNWTASESG RSGMVRDGSG VNNSSDRHGA GMHDITFTNG SNVVTSVPSE
     GGARTAALCG GNVQNRSALD DDRLINGSSG PMAGTVSSGT SHTAGIRVGN PRSIPGTPSL
     NRSYSEGSLL SAPFRKSRAR RRLRIAGLGL TMGGNAREQN AAAEQRHHPG DHSFSRLLSN
     TSTFLSISSE NLEMASFSEC TEVLPIGGDV QGGSGVGSVL RRAVSLDSVR PSGGGSRKKD
     HSGDDDYHHR HDRVGTSCEA GGSRSPSPTA SSGIESGSIK DSPMQITDAL TADSSSIDTQ
     DDPQSFGGSS SSMATTADRR SILAGGTAKG WLPDVAAVMW RRMLGALGDV NKILNPKLHA
     QVYQYLVSMT ESLIKIRMNQ GISLDGSGHS SASGVPPAST NLVPPVALVA PWCYGALALD
     AQYAQGKLYA MQLLCTIVQS GASLGNHQLP LFYHALHQAL TGEDRAMAYT ALRYLGGPRF
     LSLLLPGHTL LLLDLVHAAT VVLTSSETGP HAPRAHVAGL LGSLLCFPRT SLPGPVLQPS
     EPRIDLMECP DLQEHVLNVV LRCARREPTA KARCIAIASL GQWILQNLTN PTAQQSGEGE
     AAFKQKVPHH SSETGSRRES ITNTVNPRIR EAFQVILQAL QFKHHTIARL ASETLKLCAE
     QGARIEQIER LPQLIIDTVC LSLDIHNVPH PKESDKTVLT SLLLTLGELC MSFSVRTLQQ
     PKHHDSTEPL ILIVFRILYK IATGLQNGER IKLFTTDEDF DSTIVVDDVR ESGSGSVGDA
     GSYQTSESIA SCQSAIRLCA KTVAMHLITN LGHFPMGIGA TRLSSLVDEQ DDLMSGSFAT
     APVHPSAGTG PSGATLQREN SIAGARVDAM EHVLASPNLQ LLMLSPELVA SFIELPALKL
     PGGGATAGLL TANRQVRLLL RDLNGKACWD ASILYQEPSV SVPPPASVEY ERNATFQSSA
     PVSRHYAYST LPAGSSQLAG GNGVAGRHFA SGSTSIDPLM STAIGLPMTH GPRHTLRHRP
     VHQLPVAKDL APDLDQLDDL LQYIGYTSPE CLDSSEVPLN TAGPSPLGAS LEGQTISIIL
     NQRTIEAEAV SRQNSGPNGP LNVERSLSSA TSSYPTLVTS SGYGSYSPGQ SYADESGTGT
     LTRAANNTIP ISQQHDRNDH ATKPFQLGRI LFNQLGLAGW ERRKRTHLLQ RTDKLLRELR
     NLDNQKCRET HKMAVIYVAN GQEDKSSILR NGCGSSTYEM FVSALGWEVE LESHNGFLGG
     LPRQGCGQTA PYYATPFLEV IYHVSTRMPS DTPEAILNKT RHLGNDEVHI VWSEHNRDYR
     RDILPTEFCD VLIVIYPLKS GLFRVTVNKK PEVPWFGPLS DEMVVGGACL ASLVRASAIN
     ASRAKRSSLS LYQQYYEERN RSIDTVALRH RENSTFEDFT ARIFCPIAQQ SGGKAGGGSG
     GTVGSSIASG TNAPAPLAAA LIDHHSRGPS KTWIHHPEMV ATAREVTQQT LASVSLDQPS
     PRPLRKLHHP FKAVPKSKAN QPGIITGGGA LGMANPAGGV IAHATTTPPE SPTLPGRKIK
//