ID A0A182W3Y7_9DIPT Unreviewed; 666 AA.
AC A0A182W3Y7;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Translation initiation factor eIF2B subunit epsilon {ECO:0000256|ARBA:ARBA00044144};
DE AltName: Full=eIF2B GDP-GTP exchange factor subunit epsilon {ECO:0000256|ARBA:ARBA00044345};
OS Anopheles minimus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=112268 {ECO:0000313|EnsemblMetazoa:AMIN005048-PA, ECO:0000313|Proteomes:UP000075920};
RN [1] {ECO:0000313|Proteomes:UP000075920}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MINIMUS1 {ECO:0000313|Proteomes:UP000075920};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles minimus MINIMUS1.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMIN005048-PA}
RP IDENTIFICATION.
RC STRAIN=MINIMUS1 {ECO:0000313|EnsemblMetazoa:AMIN005048-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family.
CC {ECO:0000256|ARBA:ARBA00007878}.
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DR AlphaFoldDB; A0A182W3Y7; -.
DR STRING; 112268.A0A182W3Y7; -.
DR EnsemblMetazoa; AMIN005048-RA; AMIN005048-PA; AMIN005048.
DR VEuPathDB; VectorBase:AMIN005048; -.
DR OrthoDB; 5474157at2759; -.
DR Proteomes; UP000075920; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR CDD; cd04197; eIF-2B_epsilon_N; 1.
DR CDD; cd11558; W2_eIF2B_epsilon; 1.
DR Gene3D; 1.25.40.180; -; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035543; eIF-2B_epsilon_N.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR011004; Trimer_LpxA-like_sf.
DR InterPro; IPR003307; W2_domain.
DR InterPro; IPR044123; W2_eIF2B_epsilon.
DR PANTHER; PTHR45887; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR PANTHER; PTHR45887:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00515; eIF5C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF51161; Trimeric LpxA-like enzymes; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917}.
FT DOMAIN 498..662
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
SQ SEQUENCE 666 AA; 75324 MW; 6B45DFFCB8A06A20 CRC64;
MSKSNTIENK EIVQAIVIAD SYNGNFDPYT STKPLASLPI GNVPLIEYTL EILNRNGVEE
VILFCSNHID QVKHYIRERQ SARCTWSINM TVSIISSESC RSIGEAMRDL DARNTIRGNV
LLLGVDSVTN ANLAALLDEH KRVSKLDRGA VMTVVFKEGL RRMRTGNEVL IAMDPTTRRL
LYHQRLTQQE RERTFEVPLE LFLANRDVAV CHGLLDPQIA ICSPAALPLF ADNFDFLTRD
DFVRGVLINE EILNSRIYVA KLASEEYAMR VNNWQSFHLV NLDVINRRLY PLVPDTAISE
FRQMYKHFRN NIYRHPNVRL STSCVLDGDL VVGEESEICE GTYLRQSVFG RSCRIGRNCQ
ITNSFLMEGV VVGDGTVLNH CILERGVTVG DGCTINPGTV LGEGVEIPSR MVVPGLLLQA
SKPADDEWSA PVQKIADRAY TIPVLDEDES DSDEEDEKSG QPALNQPIVI APLPERYPPS
VYEPSDDECD SGSASPVQED ANIFLSEVLE SLKRGLSERT NAEYLILEIN SSRYAYNMAL
CEVNYYVVKA ILQIMLQEDG VVTNTVATLR RLLDYFGVVF RNYIRDRDAM MDCLKAFEEM
CSTSETMRTK IAQLVHYLYE QDLIGEEVII EWYDGMEDET IKSTLSKLVH WLQESSEEED
EEDDDD
//