ID   A0A182W9H7_9DIPT        Unreviewed;      1328 AA.
AC   A0A182W9H7;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 2.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Thioester-containing protein 1 {ECO:0008006|Google:ProtNLM};
OS   Anopheles minimus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=112268 {ECO:0000313|EnsemblMetazoa:AMIN007005-PA, ECO:0000313|Proteomes:UP000075920};
RN   [1] {ECO:0000313|Proteomes:UP000075920}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MINIMUS1 {ECO:0000313|Proteomes:UP000075920};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles minimus MINIMUS1.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AMIN007005-PA}
RP   IDENTIFICATION.
RC   STRAIN=MINIMUS1 {ECO:0000313|EnsemblMetazoa:AMIN007005-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR   STRING; 112268.A0A182W9H7; -.
DR   EnsemblMetazoa; AMIN007005-RA; AMIN007005-PA; AMIN007005.
DR   VEuPathDB; VectorBase:AMIN007005; -.
DR   OrthoDB; 3431519at2759; -.
DR   Proteomes; UP000075920; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.20.130.20; -; 1.
DR   Gene3D; 2.60.120.1540; -; 1.
DR   Gene3D; 2.60.40.1930; -; 2.
DR   Gene3D; 2.60.40.1940; -; 1.
DR   Gene3D; 2.60.40.2950; -; 1.
DR   Gene3D; 6.20.50.160; -; 1.
DR   Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR   InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR   InterPro; IPR011626; Alpha-macroglobulin_TED.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR041555; MG3.
DR   InterPro; IPR040839; MG4.
DR   InterPro; IPR049135; TEP1_CUB2.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR11412:SF176; GH01829P-RELATED; 1.
DR   PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF07677; A2M_recep; 1.
DR   Pfam; PF01835; MG2; 1.
DR   Pfam; PF17791; MG3; 1.
DR   Pfam; PF17789; MG4; 1.
DR   Pfam; PF07678; TED_complement; 1.
DR   Pfam; PF21412; TEP1_CUB2; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SMART; SM01361; A2M_recep; 1.
DR   SMART; SM01419; Thiol-ester_cl; 1.
DR   SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE   4: Predicted;
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT   DOMAIN          426..556
FT                   /note="Alpha-2-macroglobulin bait region"
FT                   /evidence="ECO:0000259|SMART:SM01359"
FT   DOMAIN          629..720
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
FT   DOMAIN          1236..1325
FT                   /note="Alpha-macroglobulin receptor-binding"
FT                   /evidence="ECO:0000259|SMART:SM01361"
SQ   SEQUENCE   1328 AA;  151465 MW;  4BB1391C8391A01D CRC64;
     MWQFISSRIL TVIIFIGAAH GMLVVGPKFI RANQNYTVAI SNLHPSLRKV NLKLCIDGHT
     DGGSKVLIET KTIEVGWNTN EQITFNIPEN LPAGNYKFTV DGQRGFSFHK ETDLKYLRKS
     IAGLIQISKP VFKPGDTVQF RVIVLDPELR PPARVNTIHV RIYDPQKNVI RQWPWARLQT
     GVFENELQIA PTPMLGIWNI SVLMNGEELV SKTFEVKEYV LSSFDVNVYP SIIPLESHQA
     LLLTIKADYH FGKPVIGLAK VELYLEDDEL DQRKEIEVYG KRLVELRFKE KLSLYEPQQN
     VRVRTTFIEK HTNRTVVKDA PITVYKHKYR VELIKESPQF RPAYSFKCAL QFRFHDGTPA
     TGITGEVKVD EIGYHETATS DNNGLIKLVL LPNKDINEMT ISYSNEDGFF YEEQVGKANV
     VTDTYFKLKL TNPVKLNEML QLTVRCNKQM TFFVYYVVSK GNIIDTGYIS SRNQNDYILK
     ATEKMLPKAR IIVATVVNRI MVYDVVDIHF EELHNNFNMS IDEQIVQPGQ QVELRMTGRP
     GAYVGLAAYD KGLLYYNHDL FWEDFMQVFD GFHSVEENAY DKFHSAGLFR MLGDDIIIKV
     AEDISARDGL LKIFPFSKSE WHRTKFPESW LWQNDTIGRF GIRTIAVAVP DTTTSWYLTG
     FSIDPEYGFG IIKKPIQLTT IQPFYIVENL PYSIKRGEVV ELHFTLFNYL GGEHIADVTL
     YNVDNQLEFV ERPLEELNYT KSVTVPSNIG VPISFSVKAR KLGEVVICVK ATILAGWKTD
     ALEKVIQVTP ESLVQSYMHS RSFCSDTYIN QTFSFYTDID KKADNESKKI EFRLIPNLLP
     AVLNNLDGLL ALPSGNGEQN MLHLGPNIVV LDYLRAIGSK DQNLIDKATS LIRQGYHKQM
     RYRRLDGSFG VLQNLTGGTF LTAFVAKSMQ TASKYISEVD MVKIEKAFDW LATKQRSSGR
     FYEVDTVNYN DMRGGLRNGI SLTSYVVTAL LENENARVKH AVVIQRAMNY LSSQMESINN
     AYDLSIATYA LMLNGHIMKD KAFQMLLQMS TLKNNNVERF WQTPNSIEAT AYALLSFVIA
     EKYVDGIPVM RWLANQRYVT GSLPRTQDTF VGLKALTKMA EKISPSRNNY TIQFKIRERF
     QKLFLQYTNG TKMIHINSEA SDVINFELPE LLNQFGLSVS GNGCGSFNLF YQYSINLMNI
     RNQFVLELQK QNTGSNYELQ LNVCASFIPT ITDRHSNMVT VEVTLPSGYV VDRNPISEQT
     AAIAKLAFDV RYGGTSVVVY YANMDDKQNC FTVNAFPQGK VTLKRPAYVV VYDTINPNWN
     AIKMYEMD
//