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Database: UniProt
Entry: A0A182WA05_9DIPT
LinkDB: A0A182WA05_9DIPT
Original site: A0A182WA05_9DIPT 
ID   A0A182WA05_9DIPT        Unreviewed;       659 AA.
AC   A0A182WA05;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   05-JUN-2019, entry version 16.
DE   RecName: Full=Ubiquitinyl hydrolase 1 {ECO:0000256|SAAS:SAAS01044305};
DE            EC=3.4.19.12 {ECO:0000256|SAAS:SAAS01044305};
OS   Anopheles minimus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=112268 {ECO:0000313|Proteomes:UP000075920, ECO:0000313|VectorBase:AMIN007183-PA};
RN   [1] {ECO:0000313|Proteomes:UP000075920, ECO:0000313|VectorBase:AMIN007183-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MINIMUS1 {ECO:0000313|Proteomes:UP000075920,
RC   ECO:0000313|VectorBase:AMIN007183-PA};
RA   Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA   Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA   Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA   Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S.,
RA   Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Anopheles minimus MINIMUS1.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|VectorBase:AMIN007183-PA}
RP   IDENTIFICATION.
RC   STRAIN=MINIMUS1 {ECO:0000313|VectorBase:AMIN007183-PA};
RG   VectorBase;
RL   Submitted (JUN-2016) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Thiol-dependent hydrolysis of ester, thioester, amide,
CC         peptide and isopeptide bonds formed by the C-terminal Gly of
CC         ubiquitin (a 76-residue protein attached to proteins as an
CC         intracellular targeting signal).; EC=3.4.19.12;
CC         Evidence={ECO:0000256|SAAS:SAAS01117307};
CC   -!- SIMILARITY: Belongs to the peptidase C19 family.
CC       {ECO:0000256|SAAS:SAAS01045498}.
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DR   VectorBase; AMIN007183-RA; AMIN007183-PA; AMIN007183.
DR   Proteomes; UP000075920; Unassembled WGS sequence.
DR   GO; GO:0036459; F:thiol-dependent ubiquitinyl hydrolase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0016579; P:protein deubiquitination; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001394; Peptidase_C19_UCH.
DR   InterPro; IPR018200; USP_CS.
DR   InterPro; IPR028889; USP_dom.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001607; Znf_UBP.
DR   Pfam; PF00443; UCH; 1.
DR   Pfam; PF02148; zf-UBP; 1.
DR   SMART; SM00290; ZnF_UBP; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS00972; USP_1; 1.
DR   PROSITE; PS00973; USP_2; 1.
DR   PROSITE; PS50235; USP_3; 1.
DR   PROSITE; PS50271; ZF_UBP; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000075920};
KW   Hydrolase {ECO:0000256|SAAS:SAAS01044238};
KW   Metal-binding {ECO:0000256|SAAS:SAAS01044152};
KW   Protease {ECO:0000256|SAAS:SAAS01044292};
KW   Thiol protease {ECO:0000256|SAAS:SAAS01044269};
KW   Ubl conjugation pathway {ECO:0000256|SAAS:SAAS01044331};
KW   Zinc {ECO:0000256|SAAS:SAAS01044373};
KW   Zinc-finger {ECO:0000256|SAAS:SAAS01044352}.
FT   DOMAIN       85    148       UBP-type. {ECO:0000259|PROSITE:PS50271}.
FT   DOMAIN      253    627       USP. {ECO:0000259|PROSITE:PS50235}.
FT   ZN_FING      85    148       UBP-type. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00502}.
FT   REGION      158    247       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A182WA05}.
FT   COMPBIAS    164    201       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A182WA05}.
SQ   SEQUENCE   659 AA;  72190 MW;  377D93AA01F2985E CRC64;
     MDCPHIVDNV GLGKESIRAV KNSTNATTAV VGAEPITPTG DPLATNVSGA VALSGVVVAA
     SPTTVLTVAS TASSSASSAA SSKHWKCTEC SISKDNWMCL QCGAVLCGRY DNGHALKHSN
     TNKNHNICMN TSNHYKCDEF VINDTNDNAL DELRQELKEG NGDQMDTISE TSSTLEEISS
     SKSTQETAST SSSSDSGWEE PSPTALVTPV PIPATTAIVS SRKLRPRKRT ISSDSNNENG
     ATTAKRKSMR RVVGLRNLGN TCFMNSVLQS LSNIQEFSCY FNTMPALEMK HKQKAYHSRS
     IKETMDDVFV VEELRKVLLN LSQGGDGSKG AISPECLFLV IWKVVPQFRG HRQHDAHEFL
     RYMLDRLHTE LQQVSFPVEL GAQKSGEHKN PYNVSGLSHL QAKGRNSIVT NVFGGVLQSE
     VRCLICGMES KKHDPFLDLS LDIPEKFYSK DHAPSDGGGN GLDAANGVNG APVCHIADCL
     SSFTEVEELA ETELYYCNSC KCKQKSTKRF WIRRLPNVLC LHIKRFRWNN FYRTKIDLRI
     AFPINALDMS QFVLNNGPET RRSNSSCNIY DLAAVIVHHG NGSSCGHYTS FAINNGVWMH
     FNDHTVKEVS STAVAECKPY ILFYIKRDPT NANRLATIGT AVPGAAGHAA LEQWILGML
//
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