ID   A0A182WB89_9DIPT        Unreviewed;       398 AA.
AC   A0A182WB89;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:AMIN007617-PA};
OS   Anopheles minimus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=112268 {ECO:0000313|EnsemblMetazoa:AMIN007617-PA, ECO:0000313|Proteomes:UP000075920};
RN   [1] {ECO:0000313|Proteomes:UP000075920}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MINIMUS1 {ECO:0000313|Proteomes:UP000075920};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles minimus MINIMUS1.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AMIN007617-PA}
RP   IDENTIFICATION.
RC   STRAIN=MINIMUS1 {ECO:0000313|EnsemblMetazoa:AMIN007617-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC       {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR   AlphaFoldDB; A0A182WB89; -.
DR   STRING; 112268.A0A182WB89; -.
DR   EnsemblMetazoa; AMIN007617-RA; AMIN007617-PA; AMIN007617.
DR   VEuPathDB; VectorBase:AMIN007617; -.
DR   OrthoDB; 5481312at2759; -.
DR   Proteomes; UP000075920; Unassembled WGS sequence.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   CDD; cd00751; thiolase; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR002155; Thiolase.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR   InterPro; IPR020610; Thiolase_AS.
DR   InterPro; IPR020617; Thiolase_C.
DR   InterPro; IPR020613; Thiolase_CS.
DR   InterPro; IPR020616; Thiolase_N.
DR   NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR   PANTHER; PTHR18919:SF107; 3-KETOACYL-COA THIOLASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR   Pfam; PF02803; Thiolase_C; 1.
DR   Pfam; PF00108; Thiolase_N; 1.
DR   PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS00098; THIOLASE_1; 1.
DR   PROSITE; PS00737; THIOLASE_2; 1.
DR   PROSITE; PS00099; THIOLASE_3; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW   Transferase {ECO:0000256|RuleBase:RU003557}.
FT   DOMAIN          8..268
FT                   /note="Thiolase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00108"
FT   DOMAIN          275..396
FT                   /note="Thiolase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02803"
FT   ACT_SITE        94
FT                   /note="Acyl-thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        354
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        384
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ   SEQUENCE   398 AA;  41605 MW;  17C65E15F7E15AB6 CRC64;
     MAALTKGVFI VAAKRTAFGT FGGAFKNTNA TQLQTVAAKA ALDAAGLKPD QVDSVNIGQV
     LVLSSTDGAF LPRHVSLGCG IPIERPALGV NRLCGSGFQA VVNGAQDILV GAAHISLTGG
     VDNMSQTPYT LRNSRFGIPL GSSPPLEDAL WTGLTDSYCK LPMALTAENL AEKHKIPREK
     VDEFAYRSQQ LWKKANDEGV FKTEITPFKL KVKGKEVDFA VDEHPRPQTT LEGLAKLPTL
     FKKNGAVTAG TASGICDGAA AVVVASEEAI KKHNLTPLAR LVAYSTVGVP PEIMGIGPVP
     AIRNVLNVAG LKIDDVDLFE INEAFGVQTL ACAQELGLDI NKLNLNGGAI ALGHPLGASG
     SRITGHLVHE LKRKNLKRAV GSACIGGGQG IALLLEAV
//