ID   A0A182WH72_9DIPT        Unreviewed;       587 AA.
AC   A0A182WH72;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   08-NOV-2023, entry version 28.
DE   RecName: Full=mRNA-decapping enzyme C-terminal domain-containing protein {ECO:0000259|Pfam:PF16741};
OS   Anopheles minimus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=112268 {ECO:0000313|EnsemblMetazoa:AMIN009724-PA, ECO:0000313|Proteomes:UP000075920};
RN   [1] {ECO:0000313|Proteomes:UP000075920}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MINIMUS1 {ECO:0000313|Proteomes:UP000075920};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles minimus MINIMUS1.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AMIN009724-PA}
RP   IDENTIFICATION.
RC   STRAIN=MINIMUS1 {ECO:0000313|EnsemblMetazoa:AMIN009724-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DCP1 family.
CC       {ECO:0000256|ARBA:ARBA00008778}.
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DR   AlphaFoldDB; A0A182WH72; -.
DR   STRING; 112268.A0A182WH72; -.
DR   EnsemblMetazoa; AMIN009724-RA; AMIN009724-PA; AMIN009724.
DR   VEuPathDB; VectorBase:AMIN009724; -.
DR   OrthoDB; 385293at2759; -.
DR   Proteomes; UP000075920; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR   GO; GO:0008047; F:enzyme activator activity; IEA:InterPro.
DR   GO; GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IEA:InterPro.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR   CDD; cd09804; Dcp1; 1.
DR   Gene3D; 6.10.140.2030; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR010334; Dcp1.
DR   InterPro; IPR031953; mRNA_decap_C.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR16290:SF0; DECAPPING PROTEIN 1, ISOFORM A; 1.
DR   PANTHER; PTHR16290; TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1; 1.
DR   Pfam; PF06058; DCP1; 1.
DR   Pfam; PF16741; mRNA_decap_C; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
PE   3: Inferred from homology;
KW   Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161}.
FT   DOMAIN          548..586
FT                   /note="mRNA-decapping enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16741"
FT   REGION          133..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          211..246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          445..516
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        223..246
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        445..501
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   587 AA;  62852 MW;  90CB4C4D4EA06076 CRC64;
     MADQTELRMN LVAIKRADPY AKDIVNSSAH VALYVFNNAE NEWEKTDIEG ALFIYSRFAE
     PFHSIFINNR LNTNSLVEPI RGQIELQSKP PFLLYRNERS RIRGFWFYNN SECDRIGGVI
     QKLVTDCGDG GGGDGGGGGA NEHRPPMNGG GEPAPSGGIY PGGGAVNGSG GEVESNNVDI
     FTMLTKAQED FQNNAPKPME HPVLNHHAVM MGNHPGPGIA IPQHQHQHQQ QQQQQQHHHH
     QQQPITNQNA PRSVVNFFAA AKQPAASEVP LFKTLAPVHT LEQIEKQHRA TTPQKDPTTG
     KVTPDVTELE NSFKRMGIPI VTGGGNNGPQ TPSAGMSELG TSPLATFINA ASLSAAMRAN
     HHQPVVPKTK LIEISELESR QNAQQQQQQQ QQTPLHELLK KSDPLGGNGT GGATVVKPAL
     MPPTMFKPTA SPAAAQEALS SLLLGGTNAN TNSPAGVTKQ QGNGTPGGQT KPGSTAGSTP
     LSSTGNKQQR STGSKQRDGS GSGVTPPKAA PANVTSSSKM MFDILSEAKT NSNLINNNNN
     ATTAVGVEPL TQNQLIQAVS YLIKHDPDFV RKLHEAYVKS FTEMISN
//