ID A0A182WIW0_9DIPT Unreviewed; 4609 AA.
AC A0A182WIW0;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 08-NOV-2023, entry version 33.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
OS Anopheles minimus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=112268 {ECO:0000313|EnsemblMetazoa:AMIN010314-PA, ECO:0000313|Proteomes:UP000075920};
RN [1] {ECO:0000313|Proteomes:UP000075920}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MINIMUS1 {ECO:0000313|Proteomes:UP000075920};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles minimus MINIMUS1.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMIN010314-PA}
RP IDENTIFICATION.
RC STRAIN=MINIMUS1 {ECO:0000313|EnsemblMetazoa:AMIN010314-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 112268.A0A182WIW0; -.
DR EnsemblMetazoa; AMIN010314-RA; AMIN010314-PA; AMIN010314.
DR VEuPathDB; VectorBase:AMIN010314; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000075920; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF4; DYNEIN HEAVY CHAIN 8, AXONEMAL-LIKE PROTEIN; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 1954..2090
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2562..2710
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 1006..1033
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3414..3490
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4609 AA; 530526 MW; CCD16F64ACC9F635 CRC64;
MTDPDPDRHL KQVLNVIGVS TKIGNVVQLV KRRRGSPPKI TEEQEIQQRL EKSREARSER
LNILATKHRH VLEVGAYILA EDQDYVAECV ADRMCDVQLL DSFFEPEGVK GLLMFYGMCP
PPGMDTGRYN AKVKQSSNQV WITDGHSDKV TVNCVGVTRH SNVKPIETKG LSDEILFAYI
SIPAGSSVVY CLVSILEKVL KPAIDHIRDY GHCNDIQKSN FKYGVNRFIN FLKSTEKDIS
HRIVFDVDRD LYMGFLLTKV QVEETACDKE RMGRVERIFS RWMEQVQRAL TQGDQIEQSP
HNAGPLVELE YWRTVLTRYT SISEFTESKV FLQFLESLKL SRCKLVKVWD DLAAELSVKL
IESRDNVRFI SSIERFWDPL YRCEPPEATR SIPSLLQVIR HVYKSSMYYN TSDRITGLLT
KIANQIIINC RLFLTNRGTI RIYEQPKKVL INKITICHNL DAAFRNSYNE TVQKMVDSPD
ETPWECSQVF VFGKLNHFKI RLARILEVME LYLKYEIIEQ VAIYGTEVFS GRIKAAYEAL
TSKPYDPLIY TEHQFDVDYE CYLKEVEIAE LDLQKFLKVQ LVNERTVESS LLILKRFEKL
QLDCLCIDRR YLDVAVMLEN EIFQIKDIYN ENRANPPVPY GVPETVGRIM WARALFRQMD
FPLACLKNRS CVLNHRKAQL CIKYYNYLCE VLIHYELLHH KAWMVFAEKA RTKLSTTIYR
KRATDNWLEL NFHPWIKQAI RETEIVLKLG LSAPDFTIVL VQNKEKIDQC FEKAKHLLKQ
NNELRLAIPP IFLPLMRTML VKLDKVFLPG LCVITWESLN VDQYLDDVES TLLETEQFYK
EVHDIWQARI EDTLNSFEST DLLTLPADPV DPNEFYGMNN RYRQSVQVYL EKKSQAMEGA
VIELINKFVH KIQVPDTDDR GNRRYQLPIG EITDENRRKE ELLPTDKYDW IRFDKLYKTP
ANPTPEAHLE ALFQDYGALN YDVNTLHIDC MELFAYFNNR IINVFVRMVK NSLEKLRSRL
ELVRLQLNKA AILSEIHPLI VTAMQLQADC CDITPSLEDI QLAFVRVVLN VVETFYAIST
WGRQAKSAER KTRRPVLAEQ RAERDWFKLI SEHKEVTRMV HEFDGGILVL KPDINYVLNQ
VYNRYEYLWK QNLFTVTLEA KPELFEKIKE DLASVTYGSH IGPIVIKLDA VVELVLRRFF
AFYNIRIEEI VDFITKQDET LKRTLTDLDD IRMAMDCLQT VQDNFSFIDV DLTFIEQTFR
TLADFEQLAI TQEQVDSVYG IRDTFKAMIK LVEKVENDII ALQVPLQREL AAGVAKFNEE
ITGFDQEFET NGPMEEGIPA KEASDRLLMF QVRFDELWRK FEMYANGEMF LGLKVNDYPV
LHKRKKEFNL LNKLYSLYLQ VMKSIDQYYE TPWQDVNIED INAELTDFQN RCRKLPKAMK
DWPAYIELKM KIDDFNNSCP LLELMCTEAM KDRHWEKLEQ ILGCKFDVTS PTFTLGNIME
APLLKFSDDI EDTCIGAVKE NDIDTKLRTV VAEWSTVNLQ FSAFKARGEL LIKPAETVEI
ISMLEDSIMI VNSLASNRFN AHFKKDIMMW LHKLVNTGEI LEKWLQVQNL WIYLEAVFVG
GDISKQLPQD AKRFAGIDKS WVRIMFRARD YPNVVQCCTG EDVMSYTLTS LLEQLETCQK
SLTGYLESKR LLFPRFFFIS DPVLLEILGQ SSDPTSIQAH LLSIFDAVAK VEFDEKTFGK
IVALYSANGE RVALANPVFC TGGVEMWLGS LLGEMQDTIR TILAQMAHNL ASPEFNFIIG
FQEFCGQAGL VGVQLLWTNE AEIALSRCRT DKTIMRVTNN RFLNLLNSLI ELTVKDLTKL
ERIRFETMVT IHVHQRDIFD DLVRFRIRTA LDFEWQKQAR FYYIEETDDV IVKITDVDFI
YQNEYLGVTE RLAITPLTDR CYITLAQAIG MSMGGAPAGP AGTGKTETTK DMGRALGKLV
VVFNCSDQMD FRGLGRIYKG LAQSGSWGCF DEFNRIELPV LSVAAQQIHI VLTARKEKKT
SFLFSDGDTV SLNPEFGLFI TMNPGYAGRQ ELPENLKIMF RSVAMMVPDR QIIMRVKLAS
CGFKDNVILA RKFFTLYKLC EEQLSKQVHY DFGLRNILSV LRTLGAQKRA NPTDTEETIV
MRVLRDMNVS KLVDEDEPLF ISLIEDLFPG IKLSTSSYKE LQKAIANSAE SLGLMNHPEW
NLKVIQLYET SLVRHGLMTL GPTGAGKTQC ILTLLKSFTE LGMPHKEIRM NPKAITAPQM
FGRLDVATND WTDGIFSTLW RRTLKVKKTD FVWLVLDGPV DAVWIENLNS VLDDNKTLTL
ANGDRITMAP NAKLVFEPDN VDNASPATVS RMGMVFMSAS VMKWEPILNG WLKTKPAEQS
DLLRRLFLKI YNDLHEFVQT KLKAKMKILE AIYIRQCCDL LEGLLAPQNE NQTSADFTDA
HVERLFLFSL MWSLGAVLEL EDRETMGEFI AKHPSKMKWP KLQPGETIFE YVVSAEGNWQ
HWNDRVEEYI YPNDSVPEFA SILVPNVDNV RTSFLIDLVA RQSKAVLLIG EQGTGKTVMI
KGYMLQYDPE YHLSKSFNFS SATTPNMFQR IIESYVEKRV GTTYGPPQQR KMSIFIDDVN
MPIVNEWGDQ VTNEIVRQLM ENRGFYSLDK PGDFLTVLDI QMLAAMIHPG GGRNDIPPRL
KRQFCIFNCA IPSNKSMDKI FGVLGEGYFC DTRFNDVTVG FVPRLVPLTR KIWQATKIKM
LPTPAKFHYV FNLRDLSRIW EGMLKIKSEQ CENIQTAINL WRHECTRVIA DRFINFEDRT
WFVDHLRSAA EQDLGSDFVH YQEEEQFFVD FLRDAPEPTG EEGDDVCLEP PKLYEEMPGF
DETTARVKMF LEQYNELIRG ATMDLVFFRD ALIHLMIISR IIGTPRGNAL LVGVGGSGKQ
SLTRLSSFIA GYKFYQITLT RAYNVNNLME DLKYLYRVSG VEGQGITFIF TDNDIKDEGF
LEYINNVLSS GEIANLFPKD EIDEITNELI PVMKKVDPKR IPTQDNLYDF FISRARANLH
IVLCFSPVGE KFRNRSLKFP GLISGCTIDW FQRWPEDALI AVSTHFLRDY DIVCTADVKV
RLIEIMAFVQ NRVAEVCIEY FERFRRQAHV TPKSFLSFLE GYKVIYRQKH ENIAVLAGRM
QTGLVKLIEA AESVDVLRVE LEEKEKDIVI ATKAAEVVLA SVTESQRAAE VVKADVLVVK
NKADILVEQI QADTLVAEEK LEAARPALEQ AEAALKTVTG ADIATVRKLG KPPYLITLIM
DVVLILFGRR MAPVKPDEER QFMLASWEQS LKVMADTGFL GKIVRYQADL INAETVDLMM
PYFNYHLYTF EAAKAACGNV AGLLKWTVAM ADFYDVNKDV LPLKANLVRQ QKKLDIAMAE
KGAAEALLKA KEEELAVVQQ MFDEAMTKKK AVLDDAKQCQ DKMDAASALI DGLADERVRW
TEQLEQFEDE TERLVGDVLI LTGFLSYTGP FNQEYRTVLQ TSWQSELSKR RIPVSRSINI
TESLTDPATI GEWNLQGLPN DELSIQNGII VTKAARYPLL IDPQSQGKMW IRNKENDFGL
VVTSLNHKYF RNHIEDCVSL GYPMLIEDIG EELDPVLDNV LEKNFIKMGN TFKVKVGDKE
VDVNDSFRMY MTTKLPNPLY TPEVSARTSI IDFTVTMRGL EDQLLGRVIL TEKRELESER
TNLIKDVTAN RRKMQELEAN LLHKLSTTQG SLVDDVTVIG VLNTSKITSI EVREKLKIAR
ETEIKINRAR EEYRPVAARG SVLYFLICSM TMVNNMYQTS LVQFLERFDI SMSRSDRHPV
PTRRINNIIE YLTYDIFRYV CRGLYEVHKY LFVLLMALNI DLDRKTVTHA EFQTFIKGGA
ALDINTSPEK PFKWIADVTW LNLVQLSKLD HFSGILDSIR SNEKGWKAWF SKEAPEEEPL
PPEGGYQSMD AFRRLLLIRA WCPDRTLFQS RRYLGMSLGE SFADPVIINY DALLEESRPL
TPLVCFLSMG SDPTPSIENL AKKNGFKCRS ISMGQGQEVH ARKLVGSSLE EGSWVLLQNC
HLGLDYMNEL MLQIMDLERA GPTAYHENFR IWMTTEPHPQ FPITFLQMSL KFTNEPPSGV
KAGLKRTYAS MSLEMFEYSD SLLYVPLIYG ISFLHTVVQE RRKFGPLGWN IPYEFNSADW
LASCMFVQNH LDALDPKVGR VSWKTMRYML GEVQYGGRVT DDYDKRLLNT FARVWFSDAM
FEETFRFFRE YRIMRFKTIE EYLEAIDNMP LVDPPQVYGL HSNADITYQS NTTKEILDTI
LSIQPKESSG GGGETREVTV ARMVHDMLGK VPPPYDPYAV KERLRIMGHQ ESMNIFLRQE
IDRIQRILLL VRQTLDDLLL AIDGVIIMNE QLRDALDNIY DARVPTVWKR GSWASASLGF
WFTELIERNA QFNSWCFRKR PNMFWMTGFF NPQGFLTAMR QEVARAHKGW ALDMISLHND
VTQMLTEECK VTPPEGVYVY GLYIDGAGWD KRFIRLQEAT NKVLYSPMPV IHVYAINSTA
PKDPKLYECP VYKKANRTDL NYITPLWLQT AKPPEHWVLR GVALLCDIK
//
