ID A0A182WIY9_9DIPT Unreviewed; 871 AA.
AC A0A182WIY9;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:AMIN010343-PA};
OS Anopheles minimus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=112268 {ECO:0000313|EnsemblMetazoa:AMIN010343-PA, ECO:0000313|Proteomes:UP000075920};
RN [1] {ECO:0000313|Proteomes:UP000075920}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MINIMUS1 {ECO:0000313|Proteomes:UP000075920};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles minimus MINIMUS1.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMIN010343-PA}
RP IDENTIFICATION.
RC STRAIN=MINIMUS1 {ECO:0000313|EnsemblMetazoa:AMIN010343-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A182WIY9; -.
DR STRING; 112268.A0A182WIY9; -.
DR EnsemblMetazoa; AMIN010343-RA; AMIN010343-PA; AMIN010343.
DR VEuPathDB; VectorBase:AMIN010343; -.
DR OrthoDB; 2877219at2759; -.
DR Proteomes; UP000075920; Unassembled WGS sequence.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR CDD; cd21050; ELD_TRPML; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR049134; MCLN_ECD.
DR InterPro; IPR039031; Mucolipin.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR12127; MUCOLIPIN; 1.
DR PANTHER; PTHR12127:SF7; SD02261P; 1.
DR Pfam; PF21381; MCLN_ECD; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 320..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 410..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 515..537
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 113..301
FT /note="Mucolipin extracytosolic"
FT /evidence="ECO:0000259|Pfam:PF21381"
FT DOMAIN 411..543
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
FT REGION 827..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 827..844
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 871 AA; 100002 MW; 815A56B6D842B6EF CRC64;
MTGFTRAEVM QRSACTDFLQ GQMTSVGVME SIREALRKGE EKHFEILYYR KDDTRMNEME
ERLRRKLQFF FMNPIEKWEA KRRFPYKFVV QVIKIVLVTL QLCLFAHSRY THVNYTWDNT
VTFSHLFLRG WDITMETNNY PPETGPLSVY MIDEFFKTID YAAAGYANLP QAIGPYSYPT
EDNTMAPIRL CLYRYKDGTI FGFNESYVFN PEIDSLCVDL YQNVTVNGSQ AYLHDKDIHI
NFSALVKAEL RFAIKTVNFK AAGPITAPDC YRFDILILFN NQDHDGQMVL RLEAEPTRLV
CHGDVEFIKN SQIDDALRSL LNILVIVICL VSFALCARAI FRAQLLRLTT CDFFKQAYGK
DLSCEGKWEF VNMWYIMIVF NDILLIIGSA LKEQIERKHF IADDWNVCSL LLGVGNSLVW
FGVLRYLGFF KTYNVVILTL KKAAPKISRF LLCALLIYAG FTFCGWLVLG PYHIKFRSLS
TTSECLFALI NGDDMFATFS IMSEKSLMLW WFCRIYLYSF TSLYIYVVLS LFISVIMDAY
DTIKKYYKDG FPQSDLRLFV GPLSPNDFSS GVFREHEEFD LENMSFVDVV KRSKFLCSEV
IAPIRSEVDD ISLFIINFED LSNPSNPEPI EQVKLSKFDK ARASFRQSFR IGHIALRDRG
LRLAGYLTPP SDATQDEDEI IAPKHPIESP ANKNTVLKVE ANIWAPMSTP ALTRTKELDC
LPHDIDTLSG PGEIVITAPD TTQHMRVESK EQSSKDMKPE FVQTKSLDFE SQLKHVESAK
LIRCYENTHS QTSRGFVEKR AHTVDDFMRE SDLQRYKAVP VKQAVAQDAR TSSSLSNVPS
DSLKAKDNGS GKYFQGTRQT INMGEKVAQV R
//
