ID A0A182WSY6_ANOQN Unreviewed; 2104 AA.
AC A0A182WSY6;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Enhancer of polycomb-like protein {ECO:0000256|RuleBase:RU361124};
OS Anopheles quadriannulatus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=34691 {ECO:0000313|EnsemblMetazoa:AQUA000639-PA, ECO:0000313|Proteomes:UP000076407};
RN [1] {ECO:0000313|Proteomes:UP000076407}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SANGQUA {ECO:0000313|Proteomes:UP000076407};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles quadriannulatus QUAD4_A.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AQUA000639-PA}
RP IDENTIFICATION.
RC STRAIN=SANGQUA {ECO:0000313|EnsemblMetazoa:AQUA000639-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC is involved in transcriptional activation of selected genes principally
CC by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is
CC also involved in DNA repair. Involved in gene silencing by neighboring
CC heterochromatin, blockage of the silencing spreading along the
CC chromosome, and required for cell cycle progression through G2/M.
CC {ECO:0000256|ARBA:ARBA00025513}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU361124}.
CC -!- SIMILARITY: Belongs to the enhancer of polycomb family.
CC {ECO:0000256|ARBA:ARBA00008035, ECO:0000256|RuleBase:RU361124}.
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DR STRING; 34691.A0A182WSY6; -.
DR EnsemblMetazoa; AQUA000639-RA; AQUA000639-PA; AQUA000639.
DR VEuPathDB; VectorBase:AQUA000639; -.
DR Proteomes; UP000076407; Unassembled WGS sequence.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR024943; Enhancer_polycomb.
DR InterPro; IPR019542; Enhancer_polycomb-like_N.
DR PANTHER; PTHR14898; ENHANCER OF POLYCOMB; 1.
DR PANTHER; PTHR14898:SF0; ENHANCER OF POLYCOMB-LIKE PROTEIN; 1.
DR Pfam; PF10513; EPL1; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361124};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU361124};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU361124}.
FT DOMAIN 7..141
FT /note="Enhancer of polycomb-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10513"
FT REGION 319..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 714..745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 828..887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 992..1038
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1089..1108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1713..1736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1791..1829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1979..2013
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2027..2049
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2082..2104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..449
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 725..745
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 828..880
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1009..1038
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1791..1820
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2104 AA; 221147 MW; B4B2473D09041C20 CRC64;
MSKLSFRARA LDPSKPMPIY LAEELPDLPE YSAINRAVPQ MPSGMEKEEE SEHHLQRAIC
TGLIIPTPEV YDSTDSEFYD KYYPPDYKLP KQLIHMQPLN LEQDIPDYDM DSADEVWVTS
HEKKLDLDPL KFEIMMDRLE KSSGQTVVTL NEAKALLKQD DEVSIAVYDY WLNKRLKMQH
PLILYVKTEN RGNMTPNNPY LAFRRRTEKM QTRKNRKNDE SSYEKMLKLR RDLSRAVTLL
DMIKRREKLK REQLHLSIEI YEKRYQAQDF HGHLLSEFTS NATRVSRPAF APIYSNQYAP
LAGGQGVNAV GTGAGSYASS SQYGGAGGSS GTNKRDNESL SSRKEKRQYK KRKQKLQKDR
GLSSGGAGSG SGGVPGSRGD AAGGSSSGSG LGNSASHHHL HPQQQLHYHG SMVGGIGGRG
VDGTVSGGHG TDHHHHLHGT GDHAVSSDDE ELANLQGTSP EEEYAYAFRR SKHSQYHRPR
ADGYGNWPWT SREENGSADP RFRFTLTSLR YPRPRCIGFA RRRLGRGGRV IIDRIATDFD
DLWSRLDYTI VESETIASLT ANEPAKSRDE QQKEDANNEP IVVPIGRRQM ERTVSVSSNC
SNTSSSAGVV VSLKPPRLLP GTTTAIAVNQ HQHHQPLVNG TDEPGAATNG TPGTIVSRRK
LILKQEHPAL RDYESDGGEI QFLASIGLMN KAESQESSEG AAFASTKRRL RFDSEEKDEL
GESVVAREQQ QQQQSGVCDE RTLSGVPNSD SIVIKSENDT EPLVSTVGGW GGSVVVKQEE
PEVMEDHQKT GAASGGGVPM AEDFEQLIDS VNSRNNARNR FNVTTVAVSS NSISSTSNVE
RVTTTTTSPT TATVGGQSQE QQQQTVGSSA SRQQGPGGSP SRLHDATRED IDAVYKDLLN
DIQSNWLHFR PKTPEPSQDD LLTLDGEDDL MEQCLGLTDR NRITLELQAL DEQLPATIFS
TNASSSSTTT KGSLGSSLFR TTPYALDNLI EPHPLSLDGE GDGSGAKAAT TAGASTSSIE
VKLETSGSSS GENNLSVPSE LNLSLNESSE DNEKMLDNIL QECAIDDPKQ LHQTSNFWNG
ILDDGMLNSL DTGPKEEDEP MPEDPDTSES NLLAFSTAKI GYHSDLVGYG RPAGAADRRT
SKSKRRKLLK RCSYLVGSSY FAVKSLPKEE IFQPLLDADG QPIVLGDGEL LDALGPGGDQ
CDLQDVDEAM DADTAVGVEA MEIKMEEEAS LAAAANELAE TSTPMALGPG EQHVVKIEPP
DELVASSERS EATLLGSTPT AVQFLPHNTT LVAPDGTTIK MEPFNHISSM AARSSTPDGA
PAGRAVPTGS TTLIPATIVV SQPSSTGGNS SMFSTTGGSV PAVVSVALQQ GGLHQLVHTS
SAPSMAPGTT MLVMQSIPSN NSAGSVQSTP SASVAGTPTS FLLSTSGNTN AMGAASSIAG
SILVQTSASS SLANAVQSSS ASSSSAASLL SNSTPIVVTV PPASSSGMSS VTAGGGTQPM
SVVMPTSGTN TVVSIAAPIV VSSASVSSLG QSIANAQSAS IIGNSAVVSS NSVTSGVNTA
TALNSYIVQH NSTPIMISHQ QMQQLANSGG ANIMTVGGQQ VVTTKQHHGE TFVLTHATGK
KQINGPSDGS KNAATSAVTM QNINHTKFHA LLGQKLGAKA NDSAHQKQLD FLRKAALVTT
ATGNNAAPKM IVKTANHGQQ LLAVTAVSSA GGMTVHHPQS ASQQQQQQQQ QQQQQQYNVI
HQNSLNSPIT IVSAQSSGQG QANKIILNSS HLLQQTGGVP LNHGKLQLTT VHQGQQQGGG
AGGQVGTVNS DGQLVTLDPS GQGQGIGGVK QADKNRVSLY NIKGRTPMIV TNQKLLNLLP
PAQQQKLANI AMQQTHQQLL LNQAGHGGST TILSKGQMIQ RVPVSIRTLT QSHQQQTNLA
DMVVVNNPNS IKFIQAAASA AAAAVAAGGG GGNVVNNNSS SSTAGTLATS RVNSITTSVA
SSTTMNASSD GGTGGGAGSS SGGGAGSSSS SSTSNCVQVA TLSTSTANVN SSGGGGTLAN
SSSSSSSNSV ASAATSTAVA AASGAAGGGS TTVVVGNANS NGGAGGNASG GNTNSTASIN
ITNR
//
