ID   A0A182WT02_ANOQN        Unreviewed;       778 AA.
AC   A0A182WT02;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   22-FEB-2023, entry version 27.
DE   RecName: Full=Cullin family profile domain-containing protein {ECO:0000259|PROSITE:PS50069};
OS   Anopheles quadriannulatus (Mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=34691 {ECO:0000313|EnsemblMetazoa:AQUA000656-PA, ECO:0000313|Proteomes:UP000076407};
RN   [1] {ECO:0000313|Proteomes:UP000076407}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SANGQUA {ECO:0000313|Proteomes:UP000076407};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles quadriannulatus QUAD4_A.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AQUA000656-PA}
RP   IDENTIFICATION.
RC   STRAIN=SANGQUA {ECO:0000313|EnsemblMetazoa:AQUA000656-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
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DR   AlphaFoldDB; A0A182WT02; -.
DR   STRING; 34691.A0A182WT02; -.
DR   EnsemblMetazoa; AQUA000656-RA; AQUA000656-PA; AQUA000656.
DR   VEuPathDB; VectorBase:AQUA000656; -.
DR   Proteomes; UP000076407; Unassembled WGS sequence.
DR   GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016157; Cullin_CS.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF169; CULLIN-1; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01256; CULLIN_1; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          418..651
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
SQ   SEQUENCE   778 AA;  90477 MW;  CB0182BBFCA18CA2 CRC64;
     MSKLNSHGAT GLKNINLEEI WTDLEAGIKQ VYKRELSLGI ARYMELYTHV YNYCTSVHQQ
     PNSRTGSSKI SKKGISAPPG GAQLVGQELY KRLKEFLENY LVRLHQNGID LMDEEVLSFY
     TKRWEEYQFS SKVLNGVCAY LNRHWVKREC EEGRKDVYEI YQLALVTWRG NLFKHLNKQV
     TNAVLKLIER ERNGETINSR LVSGVINCYV ELGLNEDDPH AKGQNLSVYK ESFENIFLED
     TERFYTRESA EFLRENPVTE YMKRVELRLN EEQKRVQVYL HESTLDRLAE KCERVLIHNH
     LDQFRTEFQN LLNSDKNQDL GRMYSLVARI KAGLFELKEI LETHIHNQGL AAIEKCGDSA
     VNDPKIYVQT ILEVHKKYNA LVLTAFNNDS GFVAALDKAC GKFINTNAVT ELSRSASKSP
     ELLAKYCDLL LKKSSKNPEE AELEDTLNQV MVVFKYIEDK DVFQKFYSKM LAKRLCQHMS
     ASDDAEASMI SKLKQACGFE YTSKLQRMFQ DIGVSKDLND QYRKHHEKLR DTRSTTQNEI
     DFSILVLSSG SWPFGQGFTF SLPFELEQSV HRFNNFYAKQ HSGRKLNWLY NMCRGELITN
     CFRMRYTLQA STFQMAVLLQ FNEETAWSIK QLGENTGINN ENLIQVLPIL LKTKLLNCYE
     GEGKLHPDST IELNKDFKNR KLRININFPL KSELKVEQEA THKNIEEDRK ILIQAAIVRI
     MKMRKMLNHT QLVNEVLNQL STRFKPKIQV IKKCIDILIE KEYLERQEGQ KDTYSYLA
//