ID A0A182WWN3_ANOQN Unreviewed; 1136 AA.
AC A0A182WWN3;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Calponin-homology (CH) domain-containing protein {ECO:0000259|PROSITE:PS50021};
OS Anopheles quadriannulatus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=34691 {ECO:0000313|EnsemblMetazoa:AQUA001941-PA, ECO:0000313|Proteomes:UP000076407};
RN [1] {ECO:0000313|Proteomes:UP000076407}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SANGQUA {ECO:0000313|Proteomes:UP000076407};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles quadriannulatus QUAD4_A.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AQUA001941-PA}
RP IDENTIFICATION.
RC STRAIN=SANGQUA {ECO:0000313|EnsemblMetazoa:AQUA001941-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the filamin family.
CC {ECO:0000256|ARBA:ARBA00009238}.
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DR AlphaFoldDB; A0A182WWN3; -.
DR STRING; 34691.A0A182WWN3; -.
DR EnsemblMetazoa; AQUA001941-RA; AQUA001941-PA; AQUA001941.
DR VEuPathDB; VectorBase:AQUA017802; -.
DR Proteomes; UP000076407; Unassembled WGS sequence.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd21227; CH_jitterbug-like_rpt1; 1.
DR CDD; cd21229; CH_jitterbug-like_rpt2; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR044801; Filamin.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR PANTHER; PTHR38537:SF17; JITTERBUG, ISOFORM N; 1.
DR Pfam; PF00307; CH; 3.
DR Pfam; PF00630; Filamin; 3.
DR SMART; SM00033; CH; 3.
DR SMART; SM00557; IG_FLMN; 3.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 2.
DR SUPFAM; SSF81296; E set domains; 3.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50194; FILAMIN_REPEAT; 4.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 57..163
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 169..272
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REPEAT 386..466
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 469..555
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 565..645
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1041..1136
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 645..784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 843..866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..708
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..733
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 843..864
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1136 AA; 125235 MW; 472C5CBD07066E1C CRC64;
MELPKGAKIT HTGLLQHTPD GKTELQKITQ AGLVARSPEG TAAKGMNIRG NEDLWVEIQA
NTFKNWVNEH LRESGLQVIE FHEDFCDGTL LCALVEGLQK RPLKPSWNKR PANQHHYLEN
VTTALNAIEA DGVKLVNIGN VDIVNGNVKL ILGLIWSLIV RYQIGRSKFP PRKLMLAWLQ
AALPDCKVSN LTTDWNSGVL LSALLDYCEP GLFPHWRTLN QSESVRNCER AMNLAYERFG
IPKVLEPEYL ASRWLDELSG MTYLSYFMRP GGPGYNATMK WVNGQIKRPV TNFTSDFNDG
KVFCEIIKDL GGPVPDPHKL SSDPSQWESN QQKVIDGGLK LGVKPVLAAK DMATADEEHL
GVMAYTTWLR WVVPRPPLAN MLTVQLESTS GRVGEPTEFR VEALSRDVDM SRVRAYVGMP
NTNTLQQVRL GARGEGTFVP DKYGMHEIVL EIDDNQLGGH FFRVLPRLVH VAPPGMAPCA
LGSLVEVLVN ATGAPKTEDI LVTAYSPSGR PLKCPLKKIE EGHSAIFKPD EAGVWEIAIT
YQGRHIQGGP FTCAVFDPSG VSVHGLDGAM PLRAHSFEVD ARGVGVAGEL HVDIVHEKRS
LVCSVERLQE NKYQVTFMPR SNGKHRVYVY FNGYDVKGSP FIMKVGSKGR SGKTRTSPHQ
HDGKLRSESP SYHFNASSLT RKADTQSGSL RREIYSPPTV QKSGSRSPQD YEPGGYIKST
SKETYTSRVM SPARHSPSPK LLFPATETDY SGGFRRSTEL LSQRRDSDEL KSSPVRLGGG
GGVDEAASSY VKTIRTENHT TKTIRTVLDG ESSPIAHIRA SPGLKSPQTV VSATLLDTRT
ASPKPLITTT STSTSSTRYI PSPVTEQRVA SPIAMHEKSN GTYKVTERNS TYKSTVTRDV
VRDSPTLERV VRSPLTTAAG TSVVDYSSNI KVNGANGQPS RRDSYDVINK TKHLFSQNSL
ESLANLTERQ LNTDLTYDRS TLDNQTEKNT HFNKFSLGTE TQPRRPVIED EGLYRAGGYL
KNYRTESNES RYESKYSSQL KGGFEPIGRD VSGARAIRVQ DIPDGVLGRP VEFEIDGSQA
GSGNLEILVN GGRVTSAVRA LGNQRFIASF TPHESGTHTV QITFNEETVP GKFIVC
//
