ID A0A182WWV2_ANOQN Unreviewed; 2892 AA.
AC A0A182WWV2;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS Anopheles quadriannulatus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=34691 {ECO:0000313|EnsemblMetazoa:AQUA002012-PA, ECO:0000313|Proteomes:UP000076407};
RN [1] {ECO:0000313|Proteomes:UP000076407}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SANGQUA {ECO:0000313|Proteomes:UP000076407};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles quadriannulatus QUAD4_A.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AQUA002012-PA}
RP IDENTIFICATION.
RC STRAIN=SANGQUA {ECO:0000313|EnsemblMetazoa:AQUA002012-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR STRING; 34691.A0A182WWV2; -.
DR EnsemblMetazoa; AQUA002012-RA; AQUA002012-PA; AQUA002012.
DR VEuPathDB; VectorBase:AQUA002012; -.
DR Proteomes; UP000076407; Unassembled WGS sequence.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF62; SODIUM CHANNEL PROTEIN 60E; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 60..78
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 85..103
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 306..332
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 691..715
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 735..766
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 824..849
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1806..1827
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1839..1860
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1866..1888
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1920..1946
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 2038..2062
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 2124..2144
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 2150..2171
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 2183..2201
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 2240..2268
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 2340..2363
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 59..337
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 629..858
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1805..2071
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 2122..2373
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 2385..2425
FT /note="Voltage-dependent L-type calcium channel IQ-
FT associated"
FT /evidence="ECO:0000259|Pfam:PF16905"
FT REGION 386..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 446..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1007..1036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1051..1085
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1403..1507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1591..1616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1663..1712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2517..2536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2554..2575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2637..2683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2827..2848
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2860..2892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..401
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..540
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1467..1493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1688..1706
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2554..2573
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2637..2665
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2868..2883
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2892 AA; 324490 MW; 473484EBB20BF5FD CRC64;
MKTIAWARAR FDSAGLTFCV VSKRFRKNYI HRFTGTKSLF CFTPWSPTRR ACVYLATNQF
FDYFVMATIL FNCIFLAMSE TIEEAEYIFL AIYTSEMIIK MIAKGFILNK YTYLRNPWNW
LDFVVITSGY ATIALDVGNL AGLRTFRVLR ALKTVSIMPG LKTIINALLH SFKQLAEVMT
LTIFCLMVFA LFALQVYMGE LRNKCVKNLP SDLTNVTHED WYMWVNDTQN WIVDEDDMPM
LCGNLTGARH CPPEYTCLCI GENPNHGYTN FDNFMWSMLT TFQLITLDYW ENVYNMVLAT
CGPMSVSFFT VVVFFGSFYL INLMLAVVAL SYEEEAEITQ EERRKDLIDH RDDSTFSFDP
ASLNVKQLSK QQRKKIDARK GVLLASYSRK KTRRRKKGKE GNGNGHSKSR SVTPSPTPSP
RHSIVRPQAL AVQRTKGILT VAPPPVVQQQ PLPQSTQPLQ QQQQQQQQPQ QQTQQQQQNN
NTLHPLGPNY RGQLLLSSRQ GSSNASEGGA NRESSLDDSG VVDDHEEQDV TGDPGEQHHK
PLHPMSQLAA QHQPPSVVQQ PLPQSQLSLP LQPHLQPQQQ REVTPVTLAL SPREVRIIKC
NGNLAKLKQQ NVYGGLHPEY LSQIVVLDPL FELGITLCIV LNTMFLALEH HGMNANVRDA
LDIGNKVTDQ GQCILKVMAL SKDFFLCGWN IFDLIIVSVS LLDLIFELIE GLTVLRGLRL
LRVLKLAQSW TTMKVLLSII ISTIGALGNL TFVLVIVIYI FAVIGMQLFS KDYTPDKFAP
DPVPRWNFND FFHSFMMIFR ILCGEWIEPL WDCMRAEEKE GASSCFAIFL PALVMGNFMV
LNLFLALLLN SFNSEELKSK KEEVGEDSKL ARSFERIRSI VRKKRNANKE KNDNYANTKL
EQLVNEIVIK QREEKKKHKQ TVLELQPLPA SQLSLPAADL QSAEPQQQQQ KYMSLPKELV
PPVDYRIPGG PIYSQSYQES LNRPVSGSDF CYDIPLKDRP LRTISGSQET VSQMDDQALP
RDDHHQQSAH PGGPPQITEV ERKILHQMSS GFGTQQSKDE PIGPLGVGDP REFDPNDRSI
HIADTAQPYD EAYLQYQKSL LNRSPSYRKS LDKISSKTSS ASSSLAHSLA AKCHSPLMQE
VLNAGSTYLR NSNISLIQTP TPVVVSRRED NHFLVADRMS QAASIGLPSA TQSPLMGGAG
GAVSAHQRSP STSSSLRKAI AAANRLSDHS LNTLSIDHDE LINQMNLKDE LLNCEQKELF
QFLNDEIDGS NNYFSETVGF SSAIVDADTE SLLLNSRKDD VIYSPDRKIS NGSLKSNLSS
ISNSIFQALE CRRGGSISSA TVDSSKPHFA VHGPVTARPT IAIDNGSLQS RRDSEDKEPL
VKASEFDEII HSFETELKSL KSLSLGRSQS QTDQASPERE RRNSDSCPGR SPMLEEVVKL
RRPKSSTVYR GSDGVNAAPA GVHGGGANRN SGSSSGSGGT DQSDASGQQQ RSEASKRRSL
EKQRNITDEE FNMGFEIKKL CDQLQAPFAA AGTGGSHEHH SPQSANGVVS LGTTSAGGTI
STIPIVFRRK NDFHSSFDRI KRLSLIERVE EAKDEEEHQT QPLPKVSSEK LPRKHLSKDR
LETLSLKSSY SVENTTQALM EGTRQLGISI QEFQRTIGQE AGSVPAGADA APGDQTAEKK
APLKKTVTYG DTSRQDSTQH PTPKRTPYKS YDSDAPLNLA GKPWHCLVSY VDDITVGGRR
NSQGVYEDPM AFPSFGRRKA PKIPQDCFPQ KCYEKCKCWD TCLKTEFGQR WYRFRQFILQ
YVDTPAFEWF VLVLIFASSI TLCFEDIHLD KNKELKRILY WTNLVFCMIF IIEMFLKWIA
LGFTKYFSSF WTILDFVIVF VSVFSLLIEE NENLKVLRSL RTLRALRPLR AISRWQGMRI
VVNALMYAIP SIFNVLLVCL VFWLIFSIMG VQFFGGKFFK CVDEAGDLLP IHIVNDKWQC
YALNYSWVNS KITFDHVGMG YLALFQVATF EGWMEVMADA VDARGVDLQP QREANLYAYL
YFVIFIVCGS FFTLNLFIGV IIDNFNMLKK KYEGGVLEMF LTESQKHYYT AMKKLGRKKP
QKVIKRPINQ FLAMFYDLSN SRRFEIAIFV LIFLNMLTMG IEHYDQPHAV FFVLEVSNAF
FTTVFGLEAI VKIVGLRYHY FTVPWNVFDF LLVLASIFGI LMEDIMIDLP ISPTLLRVVR
VFRIGRILRL IKAAKGIRKL LFALVVSLPA LFNIGALLAL ITFIYAIIGM SLFGHVRQQG
ALDDMVNFET FGRSMQLLFR LMTSAGWNDV LESLMIQPPD CELALDFSIN GDCGHPLLAI
TYFTSFIIIS YMIVINMYIA IILENFNQAH QEEEIGIVED DLEMFYIRWS KYDPHAGQFI
HFNQLSDFIA SLDPPLGIPK PNTVALVSFN LPISKGNKIH CLDILHALVK HVLGHVEETD
NFKQLQDQMD QKFKKQFPTR KELEIVSSTR IWKRQEKAAK TIQTAWKDYL RMKRERERSP
MSLDEENTQT SSPGGWQSKL SALNFLHLQV HRRGTATSSR ASSRKSSRAS DASDLSELAG
PWLNLPLMLV SGTSDMVKDV KQQHANGLEL KDAPDVKGQR RRSFYNFPFF LRHQDAVEET
STSSPQPQKR PLKDSDTNLS LTTSLEKVPV PPPATPKSKR ATSFVKKKPP LERGFSAQSA
LRLNRNAVVP DDTLSTSAAD VSILVTEPSP DVPTVPAPGE TTLVHVLVHR ESEEYQSELD
EKGGLEGAPR PVVTICVESP MESPDQDGGG GGATASAATT GAVAIPIDPE PIDVNLPRDT
SNIFYDYEEQ SGPAGQTVSA GDAPNVEDTA VTVEIANELA ECKAGRRSPG SPGDRHEQPS
DRPEADLPAQ SS
//
